Maternal malnutrition and anaemia in India: dysregulations leading to the ‘thin-fat’ phenotype in newborns

• Published in: Journal of nutritional science (Cambridge) Vol. 10; p. e91
• Main Authors: Pandit, Prachi, Galande, Sanjeev, Iris, François
• Format: Journal Article
• Language: English
• Published: Cambridge, UK Cambridge University Press 2021
• Subjects: Adult; adulthood; Amino acids; Anaemia; Anemia; Anemia - epidemiology; burden of disease; children; Diabetes; Disease; Female; Gene expression; Genotype & phenotype; Glutathione; Health risks; Human subjects; Humans; India; India - epidemiology; Infant, Low Birth Weight; Infant, Newborn; Insulin resistance; Low birth weight; Malnutrition; Malnutrition - complications; Metabolism; Molecular Nutrition; Pathological mechanisms; Phenotype; Physiological programming; Physiology; Pregnancy; Review; Rural areas; Selenium; sugars; Womens health; India; Physiological programming; Anaemia; Malnutrition; Pathological mechanisms; Low birth weight; EAA, essential amino acids; GSH, glutathione; 5-mTHF, 5-methyltetrahydrofolate; PE, phosphatidylethanolamine; LBW, low birth weight; BAT, brown adipocyte tissue; FA, fatty acid; Hcy, homocysteine; WAT, white adipocyte tissue; TG, triacylglycerol; SAM, S-adenosyl methionine

Maternal and child malnutrition and anaemia remain the leading factors for health loss in India. Low birth weight (LBW) offspring of women suffering from chronic malnutrition and anaemia often exhibit insulin resistance and infantile stunting and wasting, together with increased risk of developing c...