Boiling Histotripsy Ablation of Renal Cell Carcinoma in the Eker Rat Promotes a Systemic Inflammatory Response

• Published in: Ultrasound in medicine & biology Vol. 45; no. 1; pp. 137 - 147
• Main Authors: Schade, George R., Wang, Yak-Nam, D'Andrea, Samantha, Hwang, Joo Ha, Liles, W. Conrad, Khokhlova, Tatiana D.
• Format: Journal Article
• Language: English
• Published: England Elsevier Inc 01.01.2019
• Subjects: Animals; Carcinoma, Renal Cell - complications; Carcinoma, Renal Cell - surgery; Disease Models, Animal; Feasibility Studies; Focused ultrasound; High-intensity focused ultrasound; High-Intensity Focused Ultrasound Ablation - methods; Histotripsy; Immune response; Kidney - surgery; Kidney cancer; Kidney Neoplasms - complications; Kidney Neoplasms - surgery; Rats; Renal carcinoma; Systemic Inflammatory Response Syndrome - complications; T cells; Immune response; Kidney cancer; High-intensity focused ultrasound; Focused ultrasound; T cells; Renal carcinoma; Histotripsy

Boiling histotripsy (BH) is an experimental focused ultrasound technique that produces non-thermal mechanical ablation. We evaluated the feasibility, short-term histologic effects and the resulting acute inflammatory response to BH ablation of renal cell carcinoma (RCC) in the Eker rat. Genotyped Ek...