Expression of Mutant p53 Proteins Implicates a Lineage Relationship between Neural Stem Cells and Malignant Astrocytic Glioma in a Murine Model

• Published in: Cancer cell Vol. 15; no. 6; pp. 514 - 526
• Main Authors: Wang, Yuan, Yang, Jiong, Zheng, Huarui, Tomasek, Gerald J., Zhang, Peng, McKeever, Paul E., Lee, Eva Y.-H.P., Zhu, Yuan
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 02.06.2009
• Subjects: Animals; Astrocytes - pathology; Astrocytes - physiology; Astrocytoma - metabolism; Astrocytoma - pathology; Brain Neoplasms - metabolism; Brain Neoplasms - pathology; Cell Differentiation; Cell Lineage - physiology; Cell Transformation, Neoplastic - metabolism; Cell Transformation, Neoplastic - pathology; CELLCYCLE; Corpus Callosum - metabolism; Corpus Callosum - pathology; Disease Models, Animal; Mice; Mice, Knockout; Multipotent Stem Cells - pathology; Multipotent Stem Cells - physiology; Mutation; Neurons - pathology; Neurons - physiology; Signal Transduction - physiology; STEMCELL; Tumor Suppressor Protein p53 - biosynthesis; Tumor Suppressor Protein p53 - genetics; STEMCELL; CELLCYCLE

Recent studies have identified genes and core pathways that are altered in human glioblastoma. However, the mechanisms by which alterations of these glioblastoma genes singly and cooperatively transform brain cells remain poorly understood. Further, the cell of origin of glioblastoma is largely elus...