The Role of BANK1 in B Cell Signaling and Disease

• Published in: Cells (Basel, Switzerland) Vol. 10; no. 5; p. 1184
• Main Authors: Gómez Hernández, Gonzalo, Morell, María, Alarcón-Riquelme, Marta E.
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 12.05.2021; MDPI
• Subjects: African Americans; Amino acids; Ankyrins; Autoimmune diseases; autoimmunity; B cell receptor; B cell scaffold with ankyrin repeats; B cells; CD40; CD40 antigen; Chromosome 4; Disease; Gene expression; genetic association; Genetic diversity; Insects; Lupus; Lymphatic system; Lymphocytes B; Medicin och hälsovetenskap; Mutation; Phenotypes; Phosphorylation; Population; Proteins; Review; Synergism; Systemic lupus erythematosus; TLR7 protein; TLR9 protein; Toll-like receptors

The B cell scaffold protein with ankyrin repeats (BANK1) is expressed primarily in B cells and with multiple but discrete roles in B cell signaling, including B cell receptor signaling, CD40-related signaling, and Toll-like receptor (TLR) signaling. The gene for BANK1, located in chromosome 4, has b...