Spironolactone mitigates, but does not reverse, the progression of renal fibrosis in a transgenic hypertensive rat - Leader, Catherine J.; Kelly, Darren J.; Sammut, Ivan A.; Wilkins, Gerard T.; Walker, Robert J. (Physiological reports, 2020)
Keywords: Aldosterone - metabolism; Animals; Blood pressure; Blood Pressure - drug effects; Cardiovascular disease; Connective tissue growth factor; Creatinine; Diet; Disease Models, Animal; Feeds; Fibrosis; Fibrosis - etiology; Fibrosis - genetics; Fibrosis - pathology; Fibrosis - prevention & control; Hypertension; Hypertension - genetics; Indoles; Infiltration; Inflammation; kidney; Kidney diseases; Kidney Diseases - etiology; Kidney Diseases - pathology; Kidney Diseases - prevention & control; Macrophages; Male; Mineralocorticoid Receptor Antagonists - pharmacology; Original Research; Physiology; Proteins; Proteinuria; Rats; Rats, Transgenic; Renal cortex; spironolactone; Spironolactone - pharmacology; Urine; New Zealand; kidney; fibrosis; hypertension; spironolactone