Daphnetin Alleviates Experimental Autoimmune Encephalomyelitis via Regulating Dendritic Cell Activity

• Published in: CNS neuroscience & therapeutics Vol. 22; no. 7; pp. 558 - 567
• Main Authors: Wang, Dan, Lu, Zhe, Zhang, Hang, Jin, Su‐Feng, Yang, Hao, Li, Yun‐Man, Shi, Li‐Yun
• Format: Journal Article
• Language: English
• Published: England John Wiley & Sons, Inc 01.07.2016; John Wiley and Sons Inc
• Subjects: Animals; Central Nervous System - cytology; Cytokines - genetics; Cytokines - metabolism; Daphne; Daphnetin; Dendritic cell; Dendritic Cells - drug effects; Dendritic Cells - physiology; Disease Models, Animal; Dose-Response Relationship, Drug; Encephalomyelitis, Autoimmune, Experimental - drug therapy; Encephalomyelitis, Autoimmune, Experimental - etiology; Encephalomyelitis, Autoimmune, Experimental - immunology; Encephalomyelitis, Autoimmune, Experimental - pathology; Enzyme Activation - drug effects; Experimental autoimmune encephalomyelitis; Female; Heme Oxygenase-1 - metabolism; Lipopolysaccharides - pharmacology; Lymphocytes - drug effects; Lymphocytes - metabolism; Membrane Proteins - metabolism; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Myelin-Oligodendrocyte Glycoprotein - toxicity; NF-kappa B - metabolism; Original; Peptide Fragments - toxicity; Signal Transduction - drug effects; Spleen - drug effects; Spleen - metabolism; Spleen - pathology; Th1; Th17; Time Factors; Umbelliferones - therapeutic use; Experimental autoimmune encephalomyelitis; Dendritic cell; Daphnetin; Th1; Th17

Summary Aims Daphnetin, a coumarin derivative extracted from Daphne odora var. marginata, has been reported to have antiinflammatory and immunosuppressive properties. Our previous study indicated that it was able to remarkably suppress the neuroinflammation and suggested its potential application in...