Down‐regulation of TIMP2 by HIF‐1α/miR‐210/HIF‐3α regulatory feedback circuit enhances cancer metastasis in hepatocellular carcinoma

• Published in: Hepatology (Baltimore, Md.) Vol. 64; no. 2; pp. 473 - 487
• Main Authors: Kai, Alan Ka‐Lun, Chan, Lo Kong, Lo, Regina Cheuk‐Lam, Lee, Joyce Man‐Fong, Wong, Carmen Chak‐Lui, Wong, Jack Chun‐Ming, Ng, Irene Oi‐Lin
• Format: Journal Article
• Language: English
• Published: United States Wolters Kluwer Health, Inc 01.08.2016; John Wiley and Sons Inc
• Subjects: Adult; Aged; Aged, 80 and over; Animals; Basic Helix-Loop-Helix Transcription Factors - metabolism; Carcinoma, Hepatocellular - metabolism; Carcinoma, Hepatocellular - pathology; Cell Line, Tumor; Down-Regulation; Ectopic expression; Extracellular matrix; Feedback; Feedback, Physiological; Female; Gene Knockdown Techniques; Hepatobiliary Malignancies; Hepatocellular Carcinoma; Hepatology; Humans; Hypoxia; Hypoxia - metabolism; Hypoxia-Inducible Factor 1, alpha Subunit - metabolism; Invasiveness; Liver cancer; Liver Neoplasms, Experimental - metabolism; Liver Neoplasms, Experimental - pathology; Lung Neoplasms - secondary; Male; Metastases; Metastasis; Mice, Inbred BALB C; MicroRNAs - metabolism; Middle Aged; miRNA; Neoplasm Metastasis; Proteolysis; Proteolytic enzymes; Regulation; Regulatory Pathways; Tissue inhibitor of metalloproteinase 2; Tissue Inhibitor of Metalloproteinase-2 - metabolism; Tumors; Xenografts; Young Adult

Cancer metastasis is a multistep process that involves a series of tumor‐stromal interaction, including extracellular matrix (ECM) remodeling, which requires a concerted action of multiple proteolytic enzymes and their endogenous inhibitors. This study investigated the role of tissue inhibitor of me...