Down‐regulation of TIMP2 by HIF‐1α/miR‐210/HIF‐3α regulatory feedback circuit enhances cancer metastasis in hepatocellular carcinoma - Kai, Alan Ka‐Lun; Chan, Lo Kong; Lo, Regina Cheuk‐Lam; Lee, Joyce Man‐Fong; Wong, Carmen Chak‐Lui; Wong, Jack Chun‐Ming; Ng, Irene Oi‐Lin (Hepatology (Baltimore, Md.), 2016)
Keywords: Adult; Aged; Aged, 80 and over; Animals; Basic Helix-Loop-Helix Transcription Factors - metabolism; Carcinoma, Hepatocellular - metabolism; Carcinoma, Hepatocellular - pathology; Cell Line, Tumor; Down-Regulation; Ectopic expression; Extracellular matrix; Feedback; Feedback, Physiological; Female; Gene Knockdown Techniques; Hepatobiliary Malignancies; Hepatocellular Carcinoma; Hepatology; Humans; Hypoxia; Hypoxia - metabolism; Hypoxia-Inducible Factor 1, alpha Subunit - metabolism; Invasiveness; Liver cancer; Liver Neoplasms, Experimental - metabolism; Liver Neoplasms, Experimental - pathology; Lung Neoplasms - secondary; Male; Metastases; Metastasis; Mice, Inbred BALB C; MicroRNAs - metabolism; Middle Aged; miRNA; Neoplasm Metastasis; Proteolysis; Proteolytic enzymes; Regulation; Regulatory Pathways; Tissue inhibitor of metalloproteinase 2; Tissue Inhibitor of Metalloproteinase-2 - metabolism; Tumors; Xenografts; Young Adult