Cuminaldehyde as the Major Component of Cuminum cyminum, a Natural Aldehyde with Inhibitory Effect on Alpha-Synuclein Fibrillation and Cytotoxicity

• Published in: Journal of food science Vol. 80; no. 10; pp. H2336 - H2345
• Main Authors: Morshedi, Dina, Aliakbari, Farhang, Tayaranian-Marvian, Amir, Fassihi, Afshin, Pan-Montojo, Francisco, Pérez-Sánchez, Horacio
• Format: Journal Article
• Language: English
• Published: United States Blackwell Publishing Ltd 01.10.2015; Wiley Subscription Services, Inc
• Subjects: active ingredients; Aldehydes; alpha-synuclein; alpha-Synuclein - metabolism; Animals; antifibrillation; Assaying; baicalein; Benzaldehydes - adverse effects; Benzaldehydes - chemistry; Benzaldehydes - pharmacology; Biocompatibility; cuminaldehyde; Cuminum - chemistry; Cuminum cyminum; Cytotoxicity; essential oil; Essential oils; Fibrillation; Flavanones - pharmacology; Food science; Neurological diseases; Oils, Volatile - administration & dosage; Oils, Volatile - chemistry; Oils, Volatile - pharmacology; Parkinson disease; Parkinson Disease - physiopathology; Parkinson's disease; pathophysiology; PC12 Cells; Plant extracts; Plant Extracts - adverse effects; Plant Extracts - chemistry; Plant Extracts - pharmacology; Protein Conformation - drug effects; Proteins; Rats; Schiff bases; seeds; Seeds - chemistry; spermidine; Toxic; baicalein; antifibrillation; essential oil; alpha-synuclein; cuminaldehyde; Cuminum cyminum

Fibrillation of alpha‐synuclein (α‐SN) is a critical process in the pathophysiology of several neurodegenerative diseases, especially Parkinson's disease. Application of bioactive inhibitory compounds from herbal extracts is a potential therapeutic approach for this cytotoxic process. Here, we...