Role of B7-H1 in Immune Privilege of the Eye

• Published in: Journal of Nippon Medical School Vol. 75; no. 1; pp. 56 - 57
• Main Author: Hori, Junko
• Format: Journal Article
• Language: English
• Published: Japan The Medical Association of Nippon Medical School 2008
• Subjects: Animals; Antigens, Surface - physiology; Apoptosis Regulatory Proteins - physiology; B7-1 Antigen - physiology; B7-H1 Antigen; Cornea - immunology; Corneal Transplantation - immunology; Graft Survival - immunology; Immune Tolerance; Ligands; Membrane Glycoproteins - physiology; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Peptides - physiology; Programmed Cell Death 1 Ligand 2 Protein; Programmed Cell Death 1 Receptor; Rats; T-Lymphocytes - immunology; Transplantation, Homologous - immunology

[Background] The normal eye possesses immunologic privilege. When grafted orthotopically to the eyes of experimental animals, allogeneic corneas enjoy a relatively high level of acceptance, compared with orthotopic grafts of other types of solid tissue. Even corneas grafted into eyes of preimmunized...