Evaluation of treatment efficacy using a Bayesian mixture piecewise linear model of longitudinal biomarkers - Zhao, Lili; Feng, Dai; Neelon, Brian; Buyse, Marc (Statistics in medicine, 2015)
Keywords: Antigens; Bayes Theorem; Bayesian analysis; Bayesian hierarchical model; Biomarkers; Biomarkers, Tumor - blood; change point; Clinical trials; Clinical Trials as Topic - statistics & numerical data; Computer Simulation; Disease Progression; Endpoint Determination; Humans; Linear Models; longitudinal data; Longitudinal Studies; Male; Markov Chains; Mathematical functions; Mathematical models; mixture model; Monte Carlo Method; Multicenter Studies as Topic - statistics & numerical data; Prostate cancer; Prostate-Specific Antigen - blood; Prostate-Specific Antigen - drug effects; Prostatic Neoplasms - blood; Prostatic Neoplasms - drug therapy; Prostatic Neoplasms - pathology; PSA; Treatment Outcome; tumor growth profile; Bayesian hierarchical model; mixture model; tumor growth profile; change point; PSA; longitudinal data