Effect of mibefradil on CYP3A4 in vivo - Veronese, Maria L; Gillen, Lisa P; Dorval, Ellen P; Hauck, Walter W; Waldman, Scott A; Greenberg, Howard E (Journal of clinical pharmacology, 2003)
Keywords: Adult; Breath Tests - methods; Carbon Radioisotopes; Cross-Over Studies; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System - drug effects; Cytochrome P-450 Enzyme System - metabolism; Drug Combinations; Drug Interactions; Erythromycin - administration & dosage; Erythromycin - analogs & derivatives; Erythromycin - metabolism; Erythromycin - pharmacokinetics; Erythromycin - urine; Humans; Intestines - enzymology; Liver - enzymology; Male; Metabolic Clearance Rate - drug effects; Mibefradil - administration & dosage; Mibefradil - blood; Mibefradil - pharmacokinetics; Midazolam - blood; Midazolam - pharmacokinetics; Molecular Probes; Single-Blind Method