Interaction of a dengue virus NS1‐derived peptide with the inhibitory receptor KIR3DL1 on natural killer cells

• Published in: Clinical and experimental immunology Vol. 183; no. 3; pp. 419 - 430
• Main Authors: Townsley, E., O'Connor, G., Cosgrove, C., Woda, M., Co, M., Thomas, S. J., Kalayanarooj, S., Yoon, I.‐K., Nisalak, A., Srikiatkhachorn, A., Green, S., Stephens, H. A. F., Gostick, E., Price, D. A., Carrington, M., Alter, G., McVicar, D. W., Rothman, A. L., Mathew, A.
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 01.03.2016; John Wiley and Sons Inc
• Subjects: Acute Disease; Adolescent; Child; Child, Preschool; dengue; Dengue - immunology; Dengue - physiopathology; Dengue - virology; Dengue fever; Dengue virus; Dengue Virus - chemistry; Dengue Virus - immunology; Epitopes, T-Lymphocyte - immunology; Female; Flaviviridae; HLA; HLA-B Antigens - immunology; Humans; Infant; Killer Cells, Natural - immunology; Killer Cells, Natural - physiology; KIR; Leukocytes, Mononuclear - immunology; Male; Original; pathogenesis; Peptide Fragments - immunology; Peptide Fragments - metabolism; Protein Binding; Receptors, KIR3DL1 - immunology; Receptors, KIR3DL1 - metabolism; T cell receptors; Viral infections; Viral Nonstructural Proteins - immunology; Viral Nonstructural Proteins - metabolism; pathogenesis; HLA; KIR; NK; dengue

Summary Killer immunoglobulin‐like receptors (KIRs) interact with human leucocyte antigen (HLA) class I ligands and play a key role in the regulation and activation of NK cells. The functional importance of KIR–HLA interactions has been demonstrated for a number of chronic viral infections, but to d...