Changing the Paradigm: Omegaven for the Treatment of Liver Failure in Pediatric Short Bowel Syndrome

• Published in: Journal of pediatric gastroenterology and nutrition Vol. 48; no. 2; pp. 209 - 215
• Main Authors: Diamond, Ivan R, Sterescu, Anca, Pencharz, Paul B, Kim, Jae H, Wales, Paul W
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD Lippincott Williams & Wilkins, Inc 01.02.2009; Lippincott Williams & Wilkins
• Subjects: Biological and medical sciences; Child, Preschool; cholestasis; Cohort Studies; Fat Emulsions, Intravenous; Fatty Acids, Omega-3 - administration & dosage; Fatty Acids, Omega-3 - therapeutic use; Feeding. Feeding behavior; Female; Fundamental and applied biological sciences. Psychology; Gastroenterology. Liver. Pancreas. Abdomen; Humans; Infant; Intestine, Small - transplantation; Liver - drug effects; Liver - physiology; Liver Failure - chemically induced; Liver Failure - drug therapy; Liver. Biliary tract. Portal circulation. Exocrine pancreas; Male; Medical sciences; omega‐3 fatty acids; Other diseases. Semiology; parenteral nutrition; Parenteral Nutrition, Total - adverse effects; Recovery of Function; Retrospective Studies; short bowel syndrome; Short Bowel Syndrome - therapy; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus; Vertebrates: anatomy and physiology, studies on body, several organs or systems; Pediatrics; Hepatic disease; Short bowel syndrome; Biliary tract disease; Liver failure; Intestinal malabsorption; Hepatology; Gastroenterology; cholestasis-omega-3 fatty acids-parenteral nutrition-short bowel syndrome. Society for Pediatric Gastroenterology; and Nutrition and North American Society for Pediatric Gastroenterology; Intestinal disease; Child; Nutritional status; Human; Obesity; Nutrition disorder; Metabolic diseases; Parenteral nutrition; Fatty acids; Parenteral administration; Feeding; Treatment; and Nutrition; Cholostasis; Digestive diseases

ABSTRACT Background: Parenteral omega‐3 fatty acids, such as Omegaven, may benefit patients with pediatric short bowel syndrome (SBS) who develop parenteral nutrition–associated liver disease (PNALD). Patients and Methods: Retrospective cohort describing the outcome of all 12 children with SBS and a...