Hedgehog regulates yes‐associated protein 1 in regenerating mouse liver

• Published in: Hepatology (Baltimore, Md.) Vol. 64; no. 1; pp. 232 - 244
• Main Authors: Swiderska‐Syn, Marzena, Xie, Guanhua, Michelotti, Gregory A., Jewell, Mark L., Premont, Richard T., Syn, Wing‐Kin, Diehl, Anna Mae
• Format: Journal Article
• Language: English
• Published: United States Wolters Kluwer Health, Inc 01.07.2016
• Subjects: Adaptor Proteins, Signal Transducing - metabolism; Animals; Cell Cycle Proteins; Cell Dedifferentiation; Cell Proliferation; Gene expression; Hedgehog Proteins - metabolism; Hepatectomy; Hepatic Stellate Cells - metabolism; Hepatocytes - physiology; Liver cancer; Liver Regeneration; Male; Mice, Inbred C57BL; Mice, Transgenic; Paracrine Communication; Phosphoproteins - metabolism; Rodents; Up-Regulation
• ISSN: 0270-9139; 1527-3350
• DOI: 10.1002/hep.28542

Adult liver regeneration requires induction and suppression of proliferative activity in multiple types of liver cells. The mechanisms that orchestrate the global changes in gene expression that are required for proliferative activity to change within individual liver cells, and that coordinate prol...