Ectopic Lipid Accumulation and Reduced Glucose Tolerance in Elderly Adults Are Accompanied by Altered Skeletal Muscle Mitochondrial Activity

• Published in: The journal of clinical endocrinology and metabolism Vol. 97; no. 1; pp. 242 - 250
• Main Authors: Johannsen, Darcy L., Conley, Kevin E., Bajpeyi, Sudip, Punyanitya, Mark, Gallagher, Dympna, Zhang, Zhengyu, Covington, Jeffrey, Smith, Steven R., Ravussin, Eric
• Format: Journal Article
• Language: English
• Published: Bethesda, MD Oxford University Press 01.01.2012; Copyright by The Endocrine Society; Endocrine Society
• Subjects: Absorptiometry, Photon; Adipose Tissue; Adult; Aged; Aged, 80 and over; Aging; Biological and medical sciences; Biopsy; Body Composition; Body weight; Choristoma - complications; Choristoma - metabolism; Choristoma - pathology; Cross-Sectional Studies; Dual energy X-ray absorptiometry; Endocrine Research; Endocrinopathies; Feeding. Feeding behavior; Female; Fundamental and applied biological sciences. Psychology; Geriatrics; Glucose; Glucose Intolerance - complications; Glucose Intolerance - metabolism; Glucose Intolerance - pathology; Glucose tolerance; Humans; Insulin resistance; Lipid Metabolism - physiology; Magnetic resonance imaging; Male; Medical sciences; Metabolism; Mitochondria; Mitochondria, Muscle - metabolism; Mitochondria, Muscle - pathology; Mitochondria, Muscle - physiology; Muscular Diseases - complications; Muscular Diseases - metabolism; Muscular Diseases - pathology; Musculoskeletal system; Oxidative stress; Protonmotive force; Reactive oxygen species; Skeletal muscle; Spectroscopy; Vertebrates: anatomy and physiology, studies on body, several organs or systems; Vertebrates: endocrinology; Young Adult; Young adults; Human; Obesity; Nutrition; Nutrition disorder; Tolerance; Activity; Lipids; Metabolic diseases; Glucose; Striated muscle; Accumulation; Mitochondria; Reduction; Adult; Ectopia; Elderly; Endocrinology; Nutritional status

Context:Aging is associated with insulin resistance and unfavorable changes in body composition including increased fat accumulation, particularly in visceral and ectopic depots. Recent studies suggest that skeletal muscle mitochondrial activity may underlie some age-associated metabolic abnormaliti...