Comparison of the effects of antiarrhythmic drugs flecainide and verapamil on fKv1.4△N channel currents in Xenopus oocytes

• Published in: Acta pharmacologica Sinica Vol. 34; no. 2; pp. 221 - 230
• Main Authors: Chen, Hui, Zhang, Dong, Chao, Sheng-ping, Ren, Jiang-hua, Xu, Lin, Jiang, Xue-jun, Wang, Shi-min
• Format: Journal Article
• Language: English
• Published: Shanghai Nature Publishing Group 01.02.2013
• Subjects: Antiarrhythmics; N通道; 抗心律失常; 氟; 电流; 维拉帕米; 药物; 钙通道阻滞剂; 非洲爪蟾卵母细胞

Aim： To study the effects of Na＋ channel blocker flecainide and L-type Ca^2＋ channel antagonist verapamil on the voltage-gated fKvl.4AN channel, an N-terminal-deleted mutant of the ferret Kvl.4 K＋ channel. Methods： fKvl.4hN channels were stably expressed in Xenopus oocytes. The K^＋ currents were rec...