MiR-495 and miR-218 regulate the expression of the Onecut transcription factors HNF-6 and OC-2

• Published in: Biochemical and biophysical research communications Vol. 391; no. 1; pp. 293 - 298
• Main Authors: Simion, Alexandru, Laudadio, Ilaria, Prévot, Pierre-Paul, Raynaud, Peggy, Lemaigre, Frédéric P., Jacquemin, Patrick
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.01.2010
• Subjects: 60 APPLIED LIFE SCIENCES; Animals; Base Sequence; CELL CULTURES; Cell Line; CLONING; Development; Gene Expression Profiling; Gene Expression Regulation, Developmental; GENES; Hepatocyte Nuclear Factor 6 - genetics; HNF-6; Homeodomain Proteins - biosynthesis; Homeodomain Proteins - genetics; Humans; LIVER; Liver - embryology; Liver - metabolism; MESSENGER-RNA; MICE; MicroRNAs - genetics; MicroRNAs - metabolism; miRNA; Molecular Sequence Data; Mouse development; OC-2; Onecut Transcription Factors - biosynthesis; Onecut Transcription Factors - genetics; PANCREAS; Pancreas - embryology; Pancreas - metabolism; PHYSIOLOGY; Protein Biosynthesis - genetics; Transcription factor; TRANSCRIPTION FACTORS; Transcription Factors - biosynthesis; Transcription Factors - genetics; HNF-6; 3′UTR; Liver; miR; Development; miRNA; Pancreas; Transcription factor; OC-2; Mouse development

MicroRNAs are small, non-coding RNAs that posttranscriptionally regulate gene expression mainly by binding to the 3′UTR of their target mRNAs. Recent data revealed that microRNAs have an important role in pancreas and liver development and physiology. Using cloning and microarray profiling approache...