Genetic architecture of the human tryptophan hydroxylase 2 Gene: existence of neural isoforms and relevance for major depression

• Published in: Molecular psychiatry Vol. 13; no. 8; pp. 813 - 820
• Main Authors: Haghighi, F, Bach-Mizrachi, H, Huang, Y Y, Arango, V, Shi, S, Dwork, A J, Rosoklija, G, Sheng, H T, Morozova, I, Ju, J, Russo, J J, Mann, J J
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.08.2008; Nature Publishing Group
• Subjects: Adenine; Adult and adolescent clinical studies; Amygdala; Autopsies; Behavioral Sciences; Biological and medical sciences; Biological Psychology; Brain - enzymology; Brain stem; Chromosome Mapping; Depression; Depressive Disorder, Major - enzymology; Depressive Disorder, Major - genetics; European Continental Ancestry Group; Genetic aspects; Guanine; Humans; Hydroxylases; Isoenzymes - genetics; Isoforms; Major depressive disorder; Medical sciences; Medicine; Medicine & Public Health; Mental depression; Mental disorders; Mood disorders; Neurons - enzymology; Neurosciences; Neurotransmission; original-article; Pharmacotherapy; Polymorphism, Single Nucleotide; Prefrontal cortex; Psychiatry; Psychology. Psychoanalysis. Psychiatry; Psychopathology; Psychopathology. Psychiatry; Reverse Transcriptase Polymerase Chain Reaction; Risk factors; Serotonin; Single nucleotide polymorphisms; Single-nucleotide polymorphism; Suicidal behavior; Suicide; Suicides & suicide attempts; Tryptophan; Tryptophan hydroxylase; Tryptophan Hydroxylase - genetics; United States; New York; United States > US; genetic association; TPH2; tryptophan hydroxylase 2; Haplotype; major depression; suicide; Mood disorder; Human; Molecular form; Architecture; Enzyme; Depression; Suicide; Genetic determinism; Gene; Tryptophan 5-monooxygenase; Genetics; Oxidoreductases

Impaired brain serotonin neurotransmission is a potential component of the diathesis of major depression. Tryptophan hydroxylase-2 (TPH2), is the rate limiting biosynthetic isoenzyme for serotonin that is preferentially expressed in the brain and a cause of impaired serotonin transmission. Here, we...