Discrepancy between tissue factor activity and tissue factor expression in endotoxin-induced monocytes is associated with apoptosis and necrosis

• Published in: Thrombosis and haemostasis Vol. 94; no. 6; p. 1236
• Main Authors: Henriksson, Carola E, Klingenberg, Olav, Ovstebø, Reidun, Joø, Gun-Britt, Westvik, Ase-Brit, Kierulf, Peter
• Format: Journal Article
• Language: English
• Published: Germany 01.12.2005
• Subjects: Annexin A5 - pharmacology; Antibodies, Monoclonal; Apoptosis; Blood Coagulation - drug effects; Cells, Cultured; Cysteine Endopeptidases - metabolism; Dose-Response Relationship, Drug; Fibrinopeptide A - antagonists & inhibitors; Fibrinopeptide A - metabolism; Humans; Lipopolysaccharides - pharmacology; Monocytes - drug effects; Monocytes - enzymology; Necrosis; Neoplasm Proteins - metabolism; Phosphatidylserines - antagonists & inhibitors; Phosphatidylserines - metabolism; RNA, Messenger - metabolism; Thromboplastin - genetics; Thromboplastin - immunology; Thromboplastin - metabolism

Tissue factor (TF), the main initiator of blood coagulation, contributes to the manifestation of disseminated intravascular coagulation following septic shock in meningococcal infection. Since a direct relationship between disease severity and lipopolysaccharide (LPS) concentration in the circulatio...