Biokinetic Analysis of Ubiquitin C-Terminal Hydrolase-L1 (UCH-L1) in Severe Traumatic Brain Injury Patient Biofluids

• Published in: Journal of neurotrauma Vol. 28; no. 6; pp. 861 - 870
• Main Authors: Brophy, Gretchen M., Mondello, Stefania, Papa, Linda, Robicsek, Steven A., Gabrielli, Andrea, Tepas, Joseph, Buki, Andras, Robertson, Claudia, Tortella, Frank C., Hayes, Ronald L., Wang, Kevin K.W.
• Format: Journal Article
• Language: English
• Published: United States Mary Ann Liebert, Inc 01.06.2011
• Subjects: Adolescent; Adult; Aged; Biomarkers; Brain; Brain damage; Brain Injuries - blood; Brain Injuries - cerebrospinal fluid; Brain Injuries - mortality; Clinical outcomes; Enzyme-linked immunosorbent assay; Female; Humans; Injuries; Male; Middle Aged; Original; Physiological aspects; Prospective Studies; Severity of Illness Index; Ubiquitin; Ubiquitin Thiolesterase - blood; Ubiquitin Thiolesterase - cerebrospinal fluid; Young Adult; United States

Ubiquitin C-terminal hydrolase-L1 (UCH-L1) is a neuron-specific enzyme that has been identified as a potential biomarker of traumatic brain injury (TBI). The study objectives were to determine UCH-L1 exposure and kinetic metrics, determine correlations between biofluids, and assess outcome correlati...