Pan-Cancer Analysis of the TRP Family, Especially TRPV4 and TRPC4, and Its Expression Correlated with Prognosis, Tumor Microenvironment, and Treatment Sensitivity

• Published in: Biomolecules (Basel, Switzerland) Vol. 13; no. 2; p. 282
• Main Authors: Chen, Zhenghao, Zhao, Youquan, Tian, Ye, Cao, Rui, Shang, Donghao
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.02.2023; MDPI
• Subjects: Autophagy; Bladder cancer; Cancer; Carcinogenesis; Carcinoma; Care and treatment; Correlation analysis; Data analysis; DNA methylation; Gene expression; Genetic aspects; Health aspects; Humans; Immunosuppressive agents; Immunotherapy; Ion channels; Medical prognosis; Motility; Mutation; pan-cancer; Patient outcomes; Physiological aspects; Physiology; Prognosis; Software; Survival analysis; TME; Transcription activation; transient receptor potential channels; Transient receptor potential proteins; TRPV Cation Channels; Tumor Microenvironment; Tumorigenesis; Tumors; China; Beijing China; transient receptor potential channels; pan-cancer; TME; prognosis; immunotherapy

Background: Transient receptor potential (TRP) channels are involved in various physiological, pathological, and tumorigenesis-related processes. However, only a few studies have comprehensively analyzed TRP family members and their association with prognosis and tumor microenvironment (TME) in vari...