FKBP5 expression in human adipose tissue: potential role in glucose and lipid metabolism, adipogenesis and type 2 diabetes

• Published in: Endocrine Vol. 62; no. 1; pp. 116 - 128
• Main Authors: Sidibeh, Cherno O., Pereira, Maria J., Abalo, Xesus M., J. Boersma, Gretha, Skrtic, Stanko, Lundkvist, Per, Katsogiannos, Petros, Hausch, Felix, Castillejo-López, Casimiro, Eriksson, Jan W.
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.10.2018; Springer Nature B.V
• Subjects: Adipocytes; Adipogenesis; Adipogenesis - drug effects; Adipogenesis - physiology; Adipose tissue; Aged; akt; alpha; Dexamethasone; Dexamethasone - pharmacology; Diabetes; Diabetes mellitus; Diabetes mellitus (non-insulin dependent); Diabetes Mellitus, Type 2 - genetics; Diabetes Mellitus, Type 2 - metabolism; diet-induced obesity; differentiation; Endocrinology; Endocrinology & Metabolism; Endocrinology and Diabetes; Endokrinologi och diabetes; Explants; Female; FKBP51; Gene expression; Gene Expression - drug effects; Gene Expression - physiology; Glucocorticoids; Glucose; Glucose - metabolism; Glucose tolerance; growth; Humanities and Social Sciences; Humans; Insulin; Insulin resistance; Internal Medicine; Lipid metabolism; Lipid Metabolism - physiology; Male; mechanisms; Medicine; Medicine & Public Health; Middle Aged; multidisciplinary; Original; Original Article; ppar-gamma; SAFit1; Science; stress; Subcutaneous Fat - drug effects; Subcutaneous Fat - metabolism; Tacrolimus Binding Proteins - genetics; Tacrolimus Binding Proteins - metabolism; Type 2 diabetes; Type 2 diabetes; Insulin resistance; SAFit1; Adipose tissue; Glucocorticoids; FKBP51

Purpose Here, we explore the involvement of FKBP51 in glucocorticoid-induced insulin resistance (IR) in human subcutaneous adipose tissue (SAT), including its potential role in type 2 diabetes (T2D). Moreover, we assess the metabolic effects of reducing the activity of FKBP51 using the specific inhi...