Recombinant human C1-inhibitor prevents acute antibody-mediated rejection in alloimmunized baboons

• Published in: Kidney international Vol. 78; no. 2; pp. 152 - 159
• Main Authors: Tillou, Xavier, Poirier, Nicolas, Le Bas-Bernardet, Stéphanie, Hervouet, Jeremy, Minault, David, Renaudin, Karine, Vistoli, Fabio, Karam, Georges, Daha, Mohamed, Soulillou, Jean Paul, Blancho, Gilles
• Format: Journal Article
• Language: English
• Published: Basingstoke Elsevier Inc 01.07.2010; Nature Publishing Group; Elsevier Limited
• Subjects: Acute Disease; alloantibodies; Animals; Antibodies - immunology; antibody-mediated rejection; Biological and medical sciences; Complement C1 Inhibitor Protein - therapeutic use; Complement Inactivating Agents - therapeutic use; complement regulation; Disease Models, Animal; Graft Rejection - immunology; Graft Rejection - prevention & control; Immunization; kidney allograft; Kidney Transplantation - immunology; Medical sciences; Nephrology. Urinary tract diseases; nonhuman primate; Papio; Recombinant Proteins - therapeutic use; complement regulation; kidney allograft; nonhuman primate; alloantibodies; antibody-mediated rejection; Graft(material); Nephrology; Complement C1; Monkey; Transplantation; Homotransplantation; Urology; Isoimmunization; Prevention; Regulation(control); Surgery; Primates; Graft; Recombinant protein; Human; Antibody; Acute; Nonhuman primate; Baboon; Rejection; Vertebrata; Mammalia; Treatment; Alloantibody; Inhibitor

Acute antibody-mediated rejection is an unsolved issue in transplantation, especially in the context of pretransplant immunization. The deleterious effect of preformed cytotoxic anti-HLA antibodies through complement activation is well proven, but very little is known concerning complement blockade...