Type I Interferons: Distinct Biological Activities and Current Applications for Viral Infection

• Published in: Cellular physiology and biochemistry Vol. 51; no. 5; pp. 2377 - 2396
• Main Authors: Li, Shi-fang, Gong, Mei-jiao, Zhao, Fu-rong, Shao, Jun-jun, Xie, Yin-li, Zhang, Yong-guang, Chang, Hui-yun
• Format: Journal Article Web Resource
• Language: English
• Published: Basel, Switzerland S. Karger AG 01.01.2018; Karger; Cell Physiol Biochem Press GmbH & Co KG
• Subjects: Amino acids; Antiviral; Antiviral drugs; Bacterial infections; Cytokines; Dendritic cells; Gene expression; Hepatitis; HIV; Human immunodeficiency virus; Immunodeficiency virus; Infections; Influenza; Influenza Virus; Interferon; Life sciences; Microbiologie; Microbiology; Pandemics; Phosphorylation; Proteins; Review; Sciences du vivant; Type I IFN classes; Viral infection; Viral infections; Viruses; Immunodeficiency virus; Influenza Virus; Hepatitis; Antiviral; Type I IFN classes; Viral infection

The interferons (IFNs) are a primary defense against pathogens because of the strong antiviral activities they induce. IFNs can be classified into three groups: type I, type II and type III, according to their genetic, structural, and functional characteristics and their receptors on the cell surfac...