Anterior Leaflet Laceration to Prevent Ventricular Outflow Tract Obstruction During Transcatheter Mitral Valve Replacement
Left ventricular outflow tract (LVOT) obstruction is a leading cause of mortality and exclusion from transcatheter mitral valve replacement (TMVR). Intentional laceration of the anterior mitral valve leaflet to prevent LVOT obstruction (LAMPOON) is a transcatheter mimic of surgical chord-sparing lea...
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| Published in | Journal of the American College of Cardiology Vol. 73; no. 20; pp. 2521 - 2534 |
|---|---|
| Main Authors | , , , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Elsevier Inc
28.05.2019
Elsevier Limited |
| Subjects | |
| Online Access | Get full text |
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| Abstract | Left ventricular outflow tract (LVOT) obstruction is a leading cause of mortality and exclusion from transcatheter mitral valve replacement (TMVR). Intentional laceration of the anterior mitral valve leaflet to prevent LVOT obstruction (LAMPOON) is a transcatheter mimic of surgical chord-sparing leaflet resection.
The purpose of this prospective multicenter trial was to study LAMPOON with transseptal (Edwards Lifesciences, Irvine, California) TMVR in annuloplasty rings or native mitral annular calcification (MAC).
Subjects at high or extreme surgical risk and prohibitive risk of LVOT obstruction from TMVR were included. Eligibility was modified midtrial to exclude subjects with threatened LVOT obstruction from a Sapien 3 valve fabric skirt. The primary endpoint was procedure survival with successful LAMPOON, with successful TMVR, without reintervention, and with LVOT gradient <30 mm Hg (“optimal”) or <50 mm Hg (“acceptable”). Secondary endpoints included 30-day mortality and major adverse cardiovascular events. There was universal source-data verification and independent monitoring. All endpoints were independently adjudicated. Central laboratories analyzed echocardiogram and CT images.
Between June 2017 and June 2018, 30 subjects were enrolled equally between the MAC and ring arms. LAMPOON traversal and midline laceration was successful in 100%. Procedure survival was 100%, and 30-day survival was 93%. Primary success was achieved in 73%, driven by additional procedures for paravalvular leak (10%) and high-skirt neo-LVOT gradients observed before a protocol amendment. There were no strokes.
LAMPOON was feasible in native and annuloplasty ring anatomies in patients who were otherwise ineligible for treatment, with acceptable safety. LAMPOON was effective in preventing LVOT obstruction from TMVR. Despite LAMPOON, TMVR using Sapien 3 in annuloplasty rings and MAC still exhibits important limitations. (NHLBI DIR LAMPOON Study: Intentional Laceration of the Anterior Mitral Leaflet to Prevent Left Ventricular Outflow Tract Obstruction During Transcatheter Mitral Valve Implantation; NCT03015194)
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| AbstractList | Left ventricular outflow tract (LVOT) obstruction is a leading cause of mortality and exclusion from transcatheter mitral valve replacement (TMVR). Intentional laceration of the anterior mitral valve leaflet to prevent LVOT obstruction (LAMPOON) is a transcatheter mimic of surgical chord-sparing leaflet resection.
The purpose of this prospective multicenter trial was to study LAMPOON with transseptal (Edwards Lifesciences, Irvine, California) TMVR in annuloplasty rings or native mitral annular calcification (MAC).
Subjects at high or extreme surgical risk and prohibitive risk of LVOT obstruction from TMVR were included. Eligibility was modified midtrial to exclude subjects with threatened LVOT obstruction from a Sapien 3 valve fabric skirt. The primary endpoint was procedure survival with successful LAMPOON, with successful TMVR, without reintervention, and with LVOT gradient <30 mm Hg (“optimal”) or <50 mm Hg (“acceptable”). Secondary endpoints included 30-day mortality and major adverse cardiovascular events. There was universal source-data verification and independent monitoring. All endpoints were independently adjudicated. Central laboratories analyzed echocardiogram and CT images.
Between June 2017 and June 2018, 30 subjects were enrolled equally between the MAC and ring arms. LAMPOON traversal and midline laceration was successful in 100%. Procedure survival was 100%, and 30-day survival was 93%. Primary success was achieved in 73%, driven by additional procedures for paravalvular leak (10%) and high-skirt neo-LVOT gradients observed before a protocol amendment. There were no strokes.
LAMPOON was feasible in native and annuloplasty ring anatomies in patients who were otherwise ineligible for treatment, with acceptable safety. LAMPOON was effective in preventing LVOT obstruction from TMVR. Despite LAMPOON, TMVR using Sapien 3 in annuloplasty rings and MAC still exhibits important limitations. (NHLBI DIR LAMPOON Study: Intentional Laceration of the Anterior Mitral Leaflet to Prevent Left Ventricular Outflow Tract Obstruction During Transcatheter Mitral Valve Implantation; NCT03015194)
[Display omitted] Left ventricular outflow tract (LVOT) obstruction is a leading cause of mortality and exclusion from transcatheter mitral valve replacement (TMVR). Intentional laceration of the anterior mitral valve leaflet to prevent LVOT obstruction (LAMPOON) is a transcatheter mimic of surgical chord-sparing leaflet resection. The purpose of this prospective multicenter trial was to study LAMPOON with transseptal (Edwards Lifesciences, Irvine, California) TMVR in annuloplasty rings or native mitral annular calcification (MAC). Subjects at high or extreme surgical risk and prohibitive risk of LVOT obstruction from TMVR were included. Eligibility was modified midtrial to exclude subjects with threatened LVOT obstruction from a Sapien 3 valve fabric skirt. The primary endpoint was procedure survival with successful LAMPOON, with successful TMVR, without reintervention, and with LVOT gradient <30 mm Hg ("optimal") or <50 mm Hg ("acceptable"). Secondary endpoints included 30-day mortality and major adverse cardiovascular events. There was universal source-data verification and independent monitoring. All endpoints were independently adjudicated. Central laboratories analyzed echocardiogram and CT images. Between June 2017 and June 2018, 30 subjects were enrolled equally between the MAC and ring arms. LAMPOON traversal and midline laceration was successful in 100%. Procedure survival was 100%, and 30-day survival was 93%. Primary success was achieved in 73%, driven by additional procedures for paravalvular leak (10%) and high-skirt neo-LVOT gradients observed before a protocol amendment. There were no strokes. LAMPOON was feasible in native and annuloplasty ring anatomies in patients who were otherwise ineligible for treatment, with acceptable safety. LAMPOON was effective in preventing LVOT obstruction from TMVR. Despite LAMPOON, TMVR using Sapien 3 in annuloplasty rings and MAC still exhibits important limitations. (NHLBI DIR LAMPOON Study: Intentional Laceration of the Anterior Mitral Leaflet to Prevent Left Ventricular Outflow Tract Obstruction During Transcatheter Mitral Valve Implantation; NCT03015194). AbstractBackgroundLeft ventricular outflow tract (LVOT) obstruction is a leading cause of mortality and exclusion from transcatheter mitral valve replacement (TMVR). Intentional laceration of the anterior mitral valve leaflet to prevent LVOT obstruction (LAMPOON) is a transcatheter mimic of surgical chord-sparing leaflet resection. ObjectivesThe purpose of this prospective multicenter trial was to study LAMPOON with transseptal (Edwards Lifesciences, Irvine, California) TMVR in annuloplasty rings or native mitral annular calcification (MAC). MethodsSubjects at high or extreme surgical risk and prohibitive risk of LVOT obstruction from TMVR were included. Eligibility was modified midtrial to exclude subjects with threatened LVOT obstruction from a Sapien 3 valve fabric skirt. The primary endpoint was procedure survival with successful LAMPOON, with successful TMVR, without reintervention, and with LVOT gradient <30 mm Hg (“optimal”) or <50 mm Hg (“acceptable”). Secondary endpoints included 30-day mortality and major adverse cardiovascular events. There was universal source-data verification and independent monitoring. All endpoints were independently adjudicated. Central laboratories analyzed echocardiogram and CT images. ResultsBetween June 2017 and June 2018, 30 subjects were enrolled equally between the MAC and ring arms. LAMPOON traversal and midline laceration was successful in 100%. Procedure survival was 100%, and 30-day survival was 93%. Primary success was achieved in 73%, driven by additional procedures for paravalvular leak (10%) and high-skirt neo-LVOT gradients observed before a protocol amendment. There were no strokes. ConclusionsLAMPOON was feasible in native and annuloplasty ring anatomies in patients who were otherwise ineligible for treatment, with acceptable safety. LAMPOON was effective in preventing LVOT obstruction from TMVR. Despite LAMPOON, TMVR using Sapien 3 in annuloplasty rings and MAC still exhibits important limitations. (NHLBI DIR LAMPOON Study: Intentional Laceration of the Anterior Mitral Leaflet to Prevent Left Ventricular Outflow Tract Obstruction During Transcatheter Mitral Valve Implantation; NCT03015194) Left ventricular outflow tract (LVOT) obstruction is a leading cause of mortality and exclusion from transcatheter mitral valve replacement (TMVR). Intentional laceration of the anterior mitral valve leaflet to prevent LVOT obstruction (LAMPOON) is a transcatheter mimic of surgical chord-sparing leaflet resection.BACKGROUNDLeft ventricular outflow tract (LVOT) obstruction is a leading cause of mortality and exclusion from transcatheter mitral valve replacement (TMVR). Intentional laceration of the anterior mitral valve leaflet to prevent LVOT obstruction (LAMPOON) is a transcatheter mimic of surgical chord-sparing leaflet resection.The purpose of this prospective multicenter trial was to study LAMPOON with transseptal (Edwards Lifesciences, Irvine, California) TMVR in annuloplasty rings or native mitral annular calcification (MAC).OBJECTIVESThe purpose of this prospective multicenter trial was to study LAMPOON with transseptal (Edwards Lifesciences, Irvine, California) TMVR in annuloplasty rings or native mitral annular calcification (MAC).Subjects at high or extreme surgical risk and prohibitive risk of LVOT obstruction from TMVR were included. Eligibility was modified midtrial to exclude subjects with threatened LVOT obstruction from a Sapien 3 valve fabric skirt. The primary endpoint was procedure survival with successful LAMPOON, with successful TMVR, without reintervention, and with LVOT gradient <30 mm Hg ("optimal") or <50 mm Hg ("acceptable"). Secondary endpoints included 30-day mortality and major adverse cardiovascular events. There was universal source-data verification and independent monitoring. All endpoints were independently adjudicated. Central laboratories analyzed echocardiogram and CT images.METHODSSubjects at high or extreme surgical risk and prohibitive risk of LVOT obstruction from TMVR were included. Eligibility was modified midtrial to exclude subjects with threatened LVOT obstruction from a Sapien 3 valve fabric skirt. The primary endpoint was procedure survival with successful LAMPOON, with successful TMVR, without reintervention, and with LVOT gradient <30 mm Hg ("optimal") or <50 mm Hg ("acceptable"). Secondary endpoints included 30-day mortality and major adverse cardiovascular events. There was universal source-data verification and independent monitoring. All endpoints were independently adjudicated. Central laboratories analyzed echocardiogram and CT images.Between June 2017 and June 2018, 30 subjects were enrolled equally between the MAC and ring arms. LAMPOON traversal and midline laceration was successful in 100%. Procedure survival was 100%, and 30-day survival was 93%. Primary success was achieved in 73%, driven by additional procedures for paravalvular leak (10%) and high-skirt neo-LVOT gradients observed before a protocol amendment. There were no strokes.RESULTSBetween June 2017 and June 2018, 30 subjects were enrolled equally between the MAC and ring arms. LAMPOON traversal and midline laceration was successful in 100%. Procedure survival was 100%, and 30-day survival was 93%. Primary success was achieved in 73%, driven by additional procedures for paravalvular leak (10%) and high-skirt neo-LVOT gradients observed before a protocol amendment. There were no strokes.LAMPOON was feasible in native and annuloplasty ring anatomies in patients who were otherwise ineligible for treatment, with acceptable safety. LAMPOON was effective in preventing LVOT obstruction from TMVR. Despite LAMPOON, TMVR using Sapien 3 in annuloplasty rings and MAC still exhibits important limitations. (NHLBI DIR LAMPOON Study: Intentional Laceration of the Anterior Mitral Leaflet to Prevent Left Ventricular Outflow Tract Obstruction During Transcatheter Mitral Valve Implantation; NCT03015194).CONCLUSIONSLAMPOON was feasible in native and annuloplasty ring anatomies in patients who were otherwise ineligible for treatment, with acceptable safety. LAMPOON was effective in preventing LVOT obstruction from TMVR. Despite LAMPOON, TMVR using Sapien 3 in annuloplasty rings and MAC still exhibits important limitations. (NHLBI DIR LAMPOON Study: Intentional Laceration of the Anterior Mitral Leaflet to Prevent Left Ventricular Outflow Tract Obstruction During Transcatheter Mitral Valve Implantation; NCT03015194). BackgroundLeft ventricular outflow tract (LVOT) obstruction is a leading cause of mortality and exclusion from transcatheter mitral valve replacement (TMVR). Intentional laceration of the anterior mitral valve leaflet to prevent LVOT obstruction (LAMPOON) is a transcatheter mimic of surgical chord-sparing leaflet resection.ObjectivesThe purpose of this prospective multicenter trial was to study LAMPOON with transseptal (Edwards Lifesciences, Irvine, California) TMVR in annuloplasty rings or native mitral annular calcification (MAC).MethodsSubjects at high or extreme surgical risk and prohibitive risk of LVOT obstruction from TMVR were included. Eligibility was modified midtrial to exclude subjects with threatened LVOT obstruction from a Sapien 3 valve fabric skirt. The primary endpoint was procedure survival with successful LAMPOON, with successful TMVR, without reintervention, and with LVOT gradient <30 mm Hg (“optimal”) or <50 mm Hg (“acceptable”). Secondary endpoints included 30-day mortality and major adverse cardiovascular events. There was universal source-data verification and independent monitoring. All endpoints were independently adjudicated. Central laboratories analyzed echocardiogram and CT images.ResultsBetween June 2017 and June 2018, 30 subjects were enrolled equally between the MAC and ring arms. LAMPOON traversal and midline laceration was successful in 100%. Procedure survival was 100%, and 30-day survival was 93%. Primary success was achieved in 73%, driven by additional procedures for paravalvular leak (10%) and high-skirt neo-LVOT gradients observed before a protocol amendment. There were no strokes.ConclusionsLAMPOON was feasible in native and annuloplasty ring anatomies in patients who were otherwise ineligible for treatment, with acceptable safety. LAMPOON was effective in preventing LVOT obstruction from TMVR. Despite LAMPOON, TMVR using Sapien 3 in annuloplasty rings and MAC still exhibits important limitations. (NHLBI DIR LAMPOON Study: Intentional Laceration of the Anterior Mitral Leaflet to Prevent Left Ventricular Outflow Tract Obstruction During Transcatheter Mitral Valve Implantation; NCT03015194) |
| Author | Wang, Dee Dee McCabe, James M. Gleason, Patrick T. Lederman, Robert J. Rogers, Toby Khan, Jaffar M. Foerst, Jason R. Paone, Gaetano Eng, Marvin H. Babaliaros, Vasilis C. Tian, Xin Leshnower, Bradley G. Greenbaum, Adam B. Chen, Marcus Y. Stine, Annette M. Yazdani, Shahram |
| AuthorAffiliation | e Inova Fairfax Hospital, Fairfax, Virginia a Cardiovascular Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland f University of Washington, Seattle, Washington d Carilion Roanoke Memorial Hospital, Roanoke, Virginia h Medstar Washington Hospital Center, Washington, DC b Structural Heart and Valve Center, Emory University Hospital, Atlanta, Georgia g Office of Biostatistics Research, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland c Center for Structural Heart Disease, Division of Cardiology, and Division of Cardiac Surgery, Henry Ford Health System, Detroit, Michigan |
| AuthorAffiliation_xml | – name: c Center for Structural Heart Disease, Division of Cardiology, and Division of Cardiac Surgery, Henry Ford Health System, Detroit, Michigan – name: a Cardiovascular Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland – name: d Carilion Roanoke Memorial Hospital, Roanoke, Virginia – name: f University of Washington, Seattle, Washington – name: e Inova Fairfax Hospital, Fairfax, Virginia – name: g Office of Biostatistics Research, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland – name: h Medstar Washington Hospital Center, Washington, DC – name: b Structural Heart and Valve Center, Emory University Hospital, Atlanta, Georgia |
| Author_xml | – sequence: 1 givenname: Jaffar M. surname: Khan fullname: Khan, Jaffar M. organization: Cardiovascular Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland – sequence: 2 givenname: Vasilis C. surname: Babaliaros fullname: Babaliaros, Vasilis C. organization: Structural Heart and Valve Center, Emory University Hospital, Atlanta, Georgia – sequence: 3 givenname: Adam B. surname: Greenbaum fullname: Greenbaum, Adam B. organization: Structural Heart and Valve Center, Emory University Hospital, Atlanta, Georgia – sequence: 4 givenname: Jason R. surname: Foerst fullname: Foerst, Jason R. organization: Carilion Roanoke Memorial Hospital, Roanoke, Virginia – sequence: 5 givenname: Shahram surname: Yazdani fullname: Yazdani, Shahram organization: Inova Fairfax Hospital, Fairfax, Virginia – sequence: 6 givenname: James M. surname: McCabe fullname: McCabe, James M. organization: University of Washington, Seattle, Washington – sequence: 7 givenname: Gaetano surname: Paone fullname: Paone, Gaetano organization: Center for Structural Heart Disease, Division of Cardiology, and Division of Cardiac Surgery, Henry Ford Health System, Detroit, Michigan – sequence: 8 givenname: Marvin H. surname: Eng fullname: Eng, Marvin H. organization: Center for Structural Heart Disease, Division of Cardiology, and Division of Cardiac Surgery, Henry Ford Health System, Detroit, Michigan – sequence: 9 givenname: Bradley G. surname: Leshnower fullname: Leshnower, Bradley G. organization: Structural Heart and Valve Center, Emory University Hospital, Atlanta, Georgia – sequence: 10 givenname: Patrick T. surname: Gleason fullname: Gleason, Patrick T. organization: Structural Heart and Valve Center, Emory University Hospital, Atlanta, Georgia – sequence: 11 givenname: Marcus Y. surname: Chen fullname: Chen, Marcus Y. organization: Cardiovascular Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland – sequence: 12 givenname: Dee Dee surname: Wang fullname: Wang, Dee Dee organization: Center for Structural Heart Disease, Division of Cardiology, and Division of Cardiac Surgery, Henry Ford Health System, Detroit, Michigan – sequence: 13 givenname: Xin surname: Tian fullname: Tian, Xin organization: Office of Biostatistics Research, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland – sequence: 14 givenname: Annette M. surname: Stine fullname: Stine, Annette M. organization: Cardiovascular Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland – sequence: 15 givenname: Toby surname: Rogers fullname: Rogers, Toby organization: Cardiovascular Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland – sequence: 16 givenname: Robert J. surname: Lederman fullname: Lederman, Robert J. email: lederman@nih.gov organization: Cardiovascular Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/31118146$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1093/eurheartj/ehy271 10.1016/j.jcin.2016.06.020 10.1016/j.jcin.2018.12.001 10.1016/j.jcin.2016.01.010 10.1093/eurheartj/ehy590 10.1016/j.jcin.2017.06.069 10.1002/ccd.26649 10.1016/j.jacc.2018.02.054 10.1016/j.jcin.2017.11.035 10.1016/S0003-4975(10)63092-5 10.1002/ccd.27728 10.1007/s11936-018-0694-z 10.4244/EIJ-D-18-00510 10.1016/j.jcin.2017.01.035 10.1016/j.jacc.2017.10.061 10.1016/S0735-1097(00)00531-3 10.1016/j.jcin.2018.03.011 10.1002/ccd.27229 10.1002/ccd.25928 10.1016/j.jacc.2015.05.049 10.1002/ccd.26909 10.1016/j.jcin.2018.01.247 10.1016/j.jacc.2016.10.068 10.1016/j.jacc.2017.02.045 10.1038/s41598-018-33836-7 10.1002/ccd.27447 10.1016/j.jtcvs.2018.03.016 10.1016/j.jcmg.2018.04.005 10.1016/j.jcmg.2016.01.005 10.1093/eurheartj/ehx303 10.1002/ccd.27054 10.1016/j.jacc.2017.07.714 10.1016/j.jcin.2018.06.019 10.1016/j.echo.2009.07.013 |
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| Keywords | mitral annular calcification transcatheter mitral valve replacement LAMPOON TMVR NHLBI transseptal interventions PVL transcatheter electrosurgery valve-in-ring LVOT structural heart disease MAC intentional laceration of the anterior mitral leaflet to prevent left ventricular outflow obstruction left ventricular outflow tract National Heart Lung and Blood Institute paravalvular leak |
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| References | Yoon, Bleiziffer, Latib (bib9) 2019; 12 Yoon, Whisenant, Bleiziffer (bib23) 2017; 70 Praz, Khalique, Lee (bib13) 2018; 156 Kohli, Wei, Yoganathan, Oshinski, Leipsic, Blanke (bib33) 2018; 20 David (bib17) 1986; 41 Urena, Brochet, Lecomte (bib24) 2018; 39 Capodanno, Petronio, Prendergast (bib26) 2017; 38 Eng, Greenbaum, Wang (bib30) 2017; 90 Yoon, Whisenant, Bleiziffer (bib2) 2019; 40 Khan, Lederman (bib32) 2018; 92 Green, Porter, Bresnahan, Spertus (bib22) 2000; 35 Khan, Dvir, Greenbaum (bib37) 2018; 11 Guerrero, Urena, Himbert (bib3) 2018; 71 Guerrero (bib5) 2015 Khan, Rogers, Babaliaros, Fusari, Greenbaum, Lederman (bib20) 2018; 11 Khan, Lederman (bib31) 2017; 90 Babaliaros, Greenbaum, Khan (bib19) 2017; 10 Bapat, Rajagopal, Meduri (bib29) 2018; 71 Khan, Lederman, Sanon (bib36) 2018; 11 Stone, Adams, Abraham (bib21) 2015; 66 Regueiro, Granada, Dagenais, Rodes-Cabau (bib1) 2017; 69 De Vecchi, Marlevi, Nordsletten (bib34) 2018; 8 Khan, Rogers, Schenke (bib18) 2016; 9 Urena, Vahanian, Sondergaard (bib35) 2018; 14 Khan, Trivedi, Gomes, Lederman, Hildick-Smith (bib10) 2019 Feb 7 Urena, Himbert, Brochet (bib16) 2017; 10 Guerrero ME. MITRAL (Mitral Implantation of Transcatheter Valves): 30-day outcomes of transcatheter mitral valve replacement in patients with severe mitral valve disease secondary to mitral annular calcification or failed annuloplasty rings. Paper presented at: Transcatheter Therapeutics; Denver, Colorado; November 1, 2017. Deharo, Urena, Himbert (bib14) 2016; 9 Muller, Farivar, Jansz (bib28) 2017; 69 Blanke, Naoum, Dvir (bib6) 2017; 10 Greenbaum, Condado, Eng (bib12) 2018; 92 Zoghbi, Chambers, Dumesnil (bib25) 2009; 22 Bapat, Pirone, Kapetanakis, Rajani, Niederer (bib7) 2015; 86 Guerrero, Wang, O'Neill (bib15) 2016; 88 Wang, Eng, Greenbaum (bib8) 2018; 92 Kamioka, Babaliaros, Morse (bib27) 2018; 11 Khan, Lederman, Devireddy (bib11) 2018; 11 Praz (10.1016/j.jacc.2019.02.076_bib13) 2018; 156 Urena (10.1016/j.jacc.2019.02.076_bib24) 2018; 39 Khan (10.1016/j.jacc.2019.02.076_bib20) 2018; 11 Yoon (10.1016/j.jacc.2019.02.076_bib2) 2019; 40 Zoghbi (10.1016/j.jacc.2019.02.076_bib25) 2009; 22 Deharo (10.1016/j.jacc.2019.02.076_bib14) 2016; 9 Kohli (10.1016/j.jacc.2019.02.076_bib33) 2018; 20 David (10.1016/j.jacc.2019.02.076_bib17) 1986; 41 Green (10.1016/j.jacc.2019.02.076_bib22) 2000; 35 10.1016/j.jacc.2019.02.076_bib4 Guerrero (10.1016/j.jacc.2019.02.076_bib15) 2016; 88 Urena (10.1016/j.jacc.2019.02.076_bib35) 2018; 14 Babaliaros (10.1016/j.jacc.2019.02.076_bib19) 2017; 10 Urena (10.1016/j.jacc.2019.02.076_bib16) 2017; 10 De Vecchi (10.1016/j.jacc.2019.02.076_bib34) 2018; 8 Khan (10.1016/j.jacc.2019.02.076_bib37) 2018; 11 Khan (10.1016/j.jacc.2019.02.076_bib11) 2018; 11 Guerrero (10.1016/j.jacc.2019.02.076_bib3) 2018; 71 Bapat (10.1016/j.jacc.2019.02.076_bib7) 2015; 86 Khan (10.1016/j.jacc.2019.02.076_bib18) 2016; 9 Muller (10.1016/j.jacc.2019.02.076_bib28) 2017; 69 Khan (10.1016/j.jacc.2019.02.076_bib31) 2017; 90 Regueiro (10.1016/j.jacc.2019.02.076_bib1) 2017; 69 Khan (10.1016/j.jacc.2019.02.076_bib32) 2018; 92 Wang (10.1016/j.jacc.2019.02.076_bib8) 2018; 92 Yoon (10.1016/j.jacc.2019.02.076_bib9) 2019; 12 Eng (10.1016/j.jacc.2019.02.076_bib30) 2017; 90 Guerrero (10.1016/j.jacc.2019.02.076_bib5) Stone (10.1016/j.jacc.2019.02.076_bib21) 2015; 66 Kamioka (10.1016/j.jacc.2019.02.076_bib27) 2018; 11 Khan (10.1016/j.jacc.2019.02.076_bib10) 2019 Capodanno (10.1016/j.jacc.2019.02.076_bib26) 2017; 38 Blanke (10.1016/j.jacc.2019.02.076_bib6) 2017; 10 Greenbaum (10.1016/j.jacc.2019.02.076_bib12) 2018; 92 Khan (10.1016/j.jacc.2019.02.076_bib36) 2018; 11 Bapat (10.1016/j.jacc.2019.02.076_bib29) 2018; 71 Yoon (10.1016/j.jacc.2019.02.076_bib23) 2017; 70 31118147 - J Am Coll Cardiol. 2019 May 28;73(20):2535-2537. doi: 10.1016/j.jacc.2019.03.481. 31136789 - J Am Coll Cardiol. 2019 Jul 30;74(4):595. doi: 10.1016/j.jacc.2019.05.027. |
| References_xml | – volume: 92 start-page: 379 year: 2018 end-page: 387 ident: bib8 article-title: Validating a prediction modeling tool for left ventricular outflow tract (LVOT) obstruction after transcatheter mitral valve replacement (TMVR) publication-title: Catheter Cardiovasc Interv – volume: 92 start-page: 388 year: 2018 end-page: 389 ident: bib32 article-title: Adventures across the second dimension: predicting left ventricular outflow tract obstruction following transcatheter mitral valve replacement publication-title: Catheter Cardiovasc Interv – volume: 41 start-page: 680 year: 1986 end-page: 682 ident: bib17 article-title: Mitral valve replacement with preservation of chordae tendinae: rationale and technical considerations publication-title: Ann Thorac Surg – volume: 39 start-page: 2679 year: 2018 end-page: 2689 ident: bib24 article-title: Clinical and haemodynamic outcomes of balloon-expandable transcatheter mitral valve implantation: a 7-year experience publication-title: Eur Heart J – volume: 10 start-page: 798 year: 2017 end-page: 809 ident: bib19 article-title: Intentional percutaneous laceration of the anterior mitral leaflet to prevent outflow obstruction during transcatheter mitral valve replacement: first-in-human experience publication-title: J Am Coll Cardiol Intv – volume: 11 start-page: 1356 year: 2018 end-page: 1359 ident: bib20 article-title: Predicting left ventricular outflow tract obstruction despite anterior mitral leaflet resection: the “Skirt NeoLVOT” publication-title: J Am Coll Cardiol Img – volume: 20 start-page: 99 year: 2018 ident: bib33 article-title: Transcatheter mitral valve planning and the neo-LVOT: utilization of virtual simulation models and 3D printing publication-title: Curr Treat Options Cardiovasc Med – volume: 22 start-page: 975 year: 2009 end-page: 1014 ident: bib25 article-title: Recommendations for evaluation of prosthetic valves with echocardiography and doppler ultrasound: a report from the American Society of Echocardiography's Guidelines and Standards Committee and the Task Force on Prosthetic Valves, developed in conjunction with the American College of Cardiology Cardiovascular Imaging Committee, Cardiac Imaging Committee of the American Heart Association, the European Association of Echocardiography, a registered branch of the European Society of Cardiology, the Japanese Society of Echocardiography and the Canadian Society of Echocardiography, endorsed by the American College of Cardiology Foundation, American Heart Association, European Association of Echocardiography, a registered branch of the European Society of Cardiology, the Japanese Society of Echocardiography, and Canadian Society of Echocardiography publication-title: J Am Soc Echocardiogr – year: 2015 ident: bib5 article-title: Mitral Implantation of TRAnscatheter vaLves (MITRAL) – volume: 92 start-page: 627 year: 2018 end-page: 632 ident: bib12 article-title: Long or redundant leaflet complicating transcatheter mitral valve replacement: case vignettes that advocate for removal or reduction of the anterior mitral leaflet publication-title: Catheter Cardiovasc Interv – volume: 11 start-page: 1131 year: 2018 end-page: 1138 ident: bib27 article-title: Comparison of clinical and echocardiographic outcomes after surgical redo mitral valve replacement and transcatheter mitral valve-in-valve therapy publication-title: J Am Coll Cardiol Intv – volume: 9 start-page: e73 year: 2016 end-page: e76 ident: bib14 article-title: Bail-out alcohol septal ablation for left ventricular outflow tract obstruction after transcatheter mitral valve replacement publication-title: J Am Coll Cardiol Intv – volume: 12 start-page: 182 year: 2019 end-page: 193 ident: bib9 article-title: Predictors of left ventricular outflow tract obstruction after transcatheter mitral valve replacement publication-title: J Am Coll Cardiol Intv – volume: 70 start-page: 1121 year: 2017 end-page: 1131 ident: bib23 article-title: Transcatheter mitral valve replacement for degenerated bioprosthetic valves and failed annuloplasty rings publication-title: J Am Coll Cardiol – volume: 11 start-page: 2014 year: 2018 end-page: 2017 ident: bib11 article-title: LAMPOON to facilitate Tendyne transcatheter mitral valve replacement publication-title: J Am Coll Cardiol Intv – volume: 156 start-page: 132 year: 2018 end-page: 142 ident: bib13 article-title: Transatrial implantation of a transcatheter heart valve for severe mitral annular calcification publication-title: J Thorac Cardiovasc Surg – volume: 38 start-page: 3382 year: 2017 end-page: 3390 ident: bib26 article-title: Standardized definitions of structural deterioration and valve failure in assessing long-term durability of transcatheter and surgical aortic bioprosthetic valves: a consensus statement from the European Association of Percutaneous Cardiovascular Interventions (EAPCI) endorsed by the European Society of Cardiology (ESC) and the European Association for Cardio-Thoracic Surgery (EACTS) publication-title: Eur Heart J – volume: 86 start-page: 747 year: 2015 end-page: 760 ident: bib7 article-title: Factors influencing left ventricular outflow tract obstruction following a mitral valve-in-valve or valve-in-ring procedure, part 1 publication-title: Catheter Cardiovasc Interv – volume: 69 start-page: 2175 year: 2017 end-page: 2192 ident: bib1 article-title: Transcatheter mitral valve replacement: insights from early clinical experience and future challenges publication-title: J Am Coll Cardiol – volume: 69 start-page: 381 year: 2017 end-page: 391 ident: bib28 article-title: Transcatheter mitral valve replacement for patients with symptomatic mitral regurgitation: a global feasibility trial publication-title: J Am Coll Cardiol – volume: 40 start-page: 441 year: 2019 end-page: 451 ident: bib2 article-title: Outcomes of transcatheter mitral valve replacement for degenerated bioprostheses, failed annuloplasty rings, and mitral annular calcification publication-title: Eur Heart J – volume: 90 start-page: 329 year: 2017 end-page: 330 ident: bib31 article-title: Unnatural milieu: thrombus after transcatheter mitral valve replacement publication-title: Catheter Cardiovasc Interv – volume: 8 start-page: 15540 year: 2018 ident: bib34 article-title: Left ventricular outflow obstruction predicts increase in systolic pressure gradients and blood residence time after transcatheter mitral valve replacement publication-title: Sci Rep – volume: 71 start-page: 12 year: 2018 end-page: 21 ident: bib29 article-title: Early experience with new transcatheter mitral valve replacement publication-title: J Am Coll Cardiol – volume: 66 start-page: 308 year: 2015 end-page: 321 ident: bib21 article-title: Clinical trial design principles and endpoint definitions for transcatheter mitral valve repair and replacement: part 2: endpoint definitions: a consensus document from the Mitral Valve Academic Research Consortium publication-title: J Am Coll Cardiol – volume: 71 start-page: 1841 year: 2018 end-page: 1853 ident: bib3 article-title: 1-year outcomes of transcatheter mitral valve replacement in patients with severe mitral annular calcification publication-title: J Am Coll Cardiol – volume: 35 start-page: 1245 year: 2000 end-page: 1255 ident: bib22 article-title: Development and evaluation of the Kansas City Cardiomyopathy Questionnaire: a new health status measure for heart failure publication-title: J Am Coll Cardiol – volume: 10 start-page: 482 year: 2017 end-page: 485 ident: bib6 article-title: Predicting LVOT obstruction in transcatheter mitral valve implantation: concept of the neo-LVOT publication-title: J Am Coll Cardiol Img – volume: 88 start-page: E191 year: 2016 end-page: E197 ident: bib15 article-title: Percutaneous alcohol septal ablation to acutely reduce left ventricular outflow tract obstruction induced by transcatheter mitral valve replacement publication-title: Catheter Cardiovasc Interv – volume: 10 start-page: 1905 year: 2017 end-page: 1919 ident: bib16 article-title: Transseptal transcatheter mitral valve replacement using balloon-expandable transcatheter heart valves: a step-by-step approach publication-title: J Am Coll Cardiol Intv – volume: 11 start-page: 808 year: 2018 end-page: 811 ident: bib36 article-title: Transcatheter mitral valve replacement after transcatheter electrosurgical laceration of Alfieri STItCh (ELASTIC): first-in-human report publication-title: J Am Coll Cardiol Intv – volume: 11 start-page: 677 year: 2018 end-page: 689 ident: bib37 article-title: Transcatheter laceration of aortic leaflets to prevent coronary obstruction during transcatheter aortic valve replacement: concept to first-in-human publication-title: J Am Coll Cardiol Intv – volume: 90 start-page: 321 year: 2017 end-page: 328 ident: bib30 article-title: Thrombotic valvular dysfunction with transcatheter mitral interventions for postsurgical failures publication-title: Catheter Cardiovasc Interv – year: 2019 Feb 7 ident: bib10 article-title: 'Rescue' LAMPOON to treat transcatheter mitral valve replacement-associated left ventricular outflow tract obstruction publication-title: J Am Coll Cardiol Intv – volume: 9 start-page: 1835 year: 2016 end-page: 1843 ident: bib18 article-title: Intentional laceration of the anterior mitral valve leaflet to prevent left ventricular outflow tract obstruction during transcatheter mitral valve replacement: pre-clinical findings publication-title: J Am Coll Cardiol Intv – reference: Guerrero ME. MITRAL (Mitral Implantation of Transcatheter Valves): 30-day outcomes of transcatheter mitral valve replacement in patients with severe mitral valve disease secondary to mitral annular calcification or failed annuloplasty rings. Paper presented at: Transcatheter Therapeutics; Denver, Colorado; November 1, 2017. – volume: 14 start-page: AB83 year: 2018 end-page: AB90 ident: bib35 article-title: Patient selection for transcatheter mitral valve implantation: why is it so hard to find patients? publication-title: EuroIntervention – volume: 39 start-page: 2679 year: 2018 ident: 10.1016/j.jacc.2019.02.076_bib24 article-title: Clinical and haemodynamic outcomes of balloon-expandable transcatheter mitral valve implantation: a 7-year experience publication-title: Eur Heart J doi: 10.1093/eurheartj/ehy271 – volume: 9 start-page: 1835 year: 2016 ident: 10.1016/j.jacc.2019.02.076_bib18 article-title: Intentional laceration of the anterior mitral valve leaflet to prevent left ventricular outflow tract obstruction during transcatheter mitral valve replacement: pre-clinical findings publication-title: J Am Coll Cardiol Intv doi: 10.1016/j.jcin.2016.06.020 – volume: 12 start-page: 182 year: 2019 ident: 10.1016/j.jacc.2019.02.076_bib9 article-title: Predictors of left ventricular outflow tract obstruction after transcatheter mitral valve replacement publication-title: J Am Coll Cardiol Intv doi: 10.1016/j.jcin.2018.12.001 – volume: 9 start-page: e73 year: 2016 ident: 10.1016/j.jacc.2019.02.076_bib14 article-title: Bail-out alcohol septal ablation for left ventricular outflow tract obstruction after transcatheter mitral valve replacement publication-title: J Am Coll Cardiol Intv doi: 10.1016/j.jcin.2016.01.010 – volume: 40 start-page: 441 year: 2019 ident: 10.1016/j.jacc.2019.02.076_bib2 article-title: Outcomes of transcatheter mitral valve replacement for degenerated bioprostheses, failed annuloplasty rings, and mitral annular calcification publication-title: Eur Heart J doi: 10.1093/eurheartj/ehy590 – volume: 10 start-page: 1905 year: 2017 ident: 10.1016/j.jacc.2019.02.076_bib16 article-title: Transseptal transcatheter mitral valve replacement using balloon-expandable transcatheter heart valves: a step-by-step approach publication-title: J Am Coll Cardiol Intv doi: 10.1016/j.jcin.2017.06.069 – volume: 88 start-page: E191 year: 2016 ident: 10.1016/j.jacc.2019.02.076_bib15 article-title: Percutaneous alcohol septal ablation to acutely reduce left ventricular outflow tract obstruction induced by transcatheter mitral valve replacement publication-title: Catheter Cardiovasc Interv doi: 10.1002/ccd.26649 – ident: 10.1016/j.jacc.2019.02.076_bib5 – volume: 71 start-page: 1841 year: 2018 ident: 10.1016/j.jacc.2019.02.076_bib3 article-title: 1-year outcomes of transcatheter mitral valve replacement in patients with severe mitral annular calcification publication-title: J Am Coll Cardiol doi: 10.1016/j.jacc.2018.02.054 – volume: 11 start-page: 808 year: 2018 ident: 10.1016/j.jacc.2019.02.076_bib36 article-title: Transcatheter mitral valve replacement after transcatheter electrosurgical laceration of Alfieri STItCh (ELASTIC): first-in-human report publication-title: J Am Coll Cardiol Intv doi: 10.1016/j.jcin.2017.11.035 – volume: 41 start-page: 680 year: 1986 ident: 10.1016/j.jacc.2019.02.076_bib17 article-title: Mitral valve replacement with preservation of chordae tendinae: rationale and technical considerations publication-title: Ann Thorac Surg doi: 10.1016/S0003-4975(10)63092-5 – volume: 92 start-page: 388 year: 2018 ident: 10.1016/j.jacc.2019.02.076_bib32 article-title: Adventures across the second dimension: predicting left ventricular outflow tract obstruction following transcatheter mitral valve replacement publication-title: Catheter Cardiovasc Interv doi: 10.1002/ccd.27728 – volume: 20 start-page: 99 year: 2018 ident: 10.1016/j.jacc.2019.02.076_bib33 article-title: Transcatheter mitral valve planning and the neo-LVOT: utilization of virtual simulation models and 3D printing publication-title: Curr Treat Options Cardiovasc Med doi: 10.1007/s11936-018-0694-z – volume: 14 start-page: AB83 year: 2018 ident: 10.1016/j.jacc.2019.02.076_bib35 article-title: Patient selection for transcatheter mitral valve implantation: why is it so hard to find patients? publication-title: EuroIntervention doi: 10.4244/EIJ-D-18-00510 – volume: 10 start-page: 798 year: 2017 ident: 10.1016/j.jacc.2019.02.076_bib19 article-title: Intentional percutaneous laceration of the anterior mitral leaflet to prevent outflow obstruction during transcatheter mitral valve replacement: first-in-human experience publication-title: J Am Coll Cardiol Intv doi: 10.1016/j.jcin.2017.01.035 – volume: 71 start-page: 12 year: 2018 ident: 10.1016/j.jacc.2019.02.076_bib29 article-title: Early experience with new transcatheter mitral valve replacement publication-title: J Am Coll Cardiol doi: 10.1016/j.jacc.2017.10.061 – volume: 35 start-page: 1245 year: 2000 ident: 10.1016/j.jacc.2019.02.076_bib22 article-title: Development and evaluation of the Kansas City Cardiomyopathy Questionnaire: a new health status measure for heart failure publication-title: J Am Coll Cardiol doi: 10.1016/S0735-1097(00)00531-3 – volume: 11 start-page: 1131 year: 2018 ident: 10.1016/j.jacc.2019.02.076_bib27 article-title: Comparison of clinical and echocardiographic outcomes after surgical redo mitral valve replacement and transcatheter mitral valve-in-valve therapy publication-title: J Am Coll Cardiol Intv doi: 10.1016/j.jcin.2018.03.011 – ident: 10.1016/j.jacc.2019.02.076_bib4 – volume: 90 start-page: 329 year: 2017 ident: 10.1016/j.jacc.2019.02.076_bib31 article-title: Unnatural milieu: thrombus after transcatheter mitral valve replacement publication-title: Catheter Cardiovasc Interv doi: 10.1002/ccd.27229 – volume: 86 start-page: 747 year: 2015 ident: 10.1016/j.jacc.2019.02.076_bib7 article-title: Factors influencing left ventricular outflow tract obstruction following a mitral valve-in-valve or valve-in-ring procedure, part 1 publication-title: Catheter Cardiovasc Interv doi: 10.1002/ccd.25928 – volume: 66 start-page: 308 year: 2015 ident: 10.1016/j.jacc.2019.02.076_bib21 article-title: Clinical trial design principles and endpoint definitions for transcatheter mitral valve repair and replacement: part 2: endpoint definitions: a consensus document from the Mitral Valve Academic Research Consortium publication-title: J Am Coll Cardiol doi: 10.1016/j.jacc.2015.05.049 – volume: 90 start-page: 321 year: 2017 ident: 10.1016/j.jacc.2019.02.076_bib30 article-title: Thrombotic valvular dysfunction with transcatheter mitral interventions for postsurgical failures publication-title: Catheter Cardiovasc Interv doi: 10.1002/ccd.26909 – volume: 11 start-page: 677 year: 2018 ident: 10.1016/j.jacc.2019.02.076_bib37 article-title: Transcatheter laceration of aortic leaflets to prevent coronary obstruction during transcatheter aortic valve replacement: concept to first-in-human publication-title: J Am Coll Cardiol Intv doi: 10.1016/j.jcin.2018.01.247 – volume: 69 start-page: 381 year: 2017 ident: 10.1016/j.jacc.2019.02.076_bib28 article-title: Transcatheter mitral valve replacement for patients with symptomatic mitral regurgitation: a global feasibility trial publication-title: J Am Coll Cardiol doi: 10.1016/j.jacc.2016.10.068 – volume: 69 start-page: 2175 year: 2017 ident: 10.1016/j.jacc.2019.02.076_bib1 article-title: Transcatheter mitral valve replacement: insights from early clinical experience and future challenges publication-title: J Am Coll Cardiol doi: 10.1016/j.jacc.2017.02.045 – volume: 8 start-page: 15540 year: 2018 ident: 10.1016/j.jacc.2019.02.076_bib34 article-title: Left ventricular outflow obstruction predicts increase in systolic pressure gradients and blood residence time after transcatheter mitral valve replacement publication-title: Sci Rep doi: 10.1038/s41598-018-33836-7 – volume: 92 start-page: 379 year: 2018 ident: 10.1016/j.jacc.2019.02.076_bib8 article-title: Validating a prediction modeling tool for left ventricular outflow tract (LVOT) obstruction after transcatheter mitral valve replacement (TMVR) publication-title: Catheter Cardiovasc Interv doi: 10.1002/ccd.27447 – volume: 156 start-page: 132 year: 2018 ident: 10.1016/j.jacc.2019.02.076_bib13 article-title: Transatrial implantation of a transcatheter heart valve for severe mitral annular calcification publication-title: J Thorac Cardiovasc Surg doi: 10.1016/j.jtcvs.2018.03.016 – volume: 11 start-page: 1356 year: 2018 ident: 10.1016/j.jacc.2019.02.076_bib20 article-title: Predicting left ventricular outflow tract obstruction despite anterior mitral leaflet resection: the “Skirt NeoLVOT” publication-title: J Am Coll Cardiol Img doi: 10.1016/j.jcmg.2018.04.005 – volume: 10 start-page: 482 year: 2017 ident: 10.1016/j.jacc.2019.02.076_bib6 article-title: Predicting LVOT obstruction in transcatheter mitral valve implantation: concept of the neo-LVOT publication-title: J Am Coll Cardiol Img doi: 10.1016/j.jcmg.2016.01.005 – volume: 38 start-page: 3382 year: 2017 ident: 10.1016/j.jacc.2019.02.076_bib26 publication-title: Eur Heart J doi: 10.1093/eurheartj/ehx303 – year: 2019 ident: 10.1016/j.jacc.2019.02.076_bib10 article-title: 'Rescue' LAMPOON to treat transcatheter mitral valve replacement-associated left ventricular outflow tract obstruction publication-title: J Am Coll Cardiol Intv – volume: 92 start-page: 627 year: 2018 ident: 10.1016/j.jacc.2019.02.076_bib12 article-title: Long or redundant leaflet complicating transcatheter mitral valve replacement: case vignettes that advocate for removal or reduction of the anterior mitral leaflet publication-title: Catheter Cardiovasc Interv doi: 10.1002/ccd.27054 – volume: 70 start-page: 1121 year: 2017 ident: 10.1016/j.jacc.2019.02.076_bib23 article-title: Transcatheter mitral valve replacement for degenerated bioprosthetic valves and failed annuloplasty rings publication-title: J Am Coll Cardiol doi: 10.1016/j.jacc.2017.07.714 – volume: 11 start-page: 2014 year: 2018 ident: 10.1016/j.jacc.2019.02.076_bib11 article-title: LAMPOON to facilitate Tendyne transcatheter mitral valve replacement publication-title: J Am Coll Cardiol Intv doi: 10.1016/j.jcin.2018.06.019 – volume: 22 start-page: 975 year: 2009 ident: 10.1016/j.jacc.2019.02.076_bib25 publication-title: J Am Soc Echocardiogr doi: 10.1016/j.echo.2009.07.013 – reference: 31136789 - J Am Coll Cardiol. 2019 Jul 30;74(4):595. doi: 10.1016/j.jacc.2019.05.027. – reference: 31118147 - J Am Coll Cardiol. 2019 May 28;73(20):2535-2537. doi: 10.1016/j.jacc.2019.03.481. |
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| Snippet | Left ventricular outflow tract (LVOT) obstruction is a leading cause of mortality and exclusion from transcatheter mitral valve replacement (TMVR). Intentional... AbstractBackgroundLeft ventricular outflow tract (LVOT) obstruction is a leading cause of mortality and exclusion from transcatheter mitral valve replacement... BackgroundLeft ventricular outflow tract (LVOT) obstruction is a leading cause of mortality and exclusion from transcatheter mitral valve replacement (TMVR).... |
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| SubjectTerms | Aged Aged, 80 and over Alcohol Calcification Cardiac Catheterization - methods Cardiology Cardiovascular Cardiovascular diseases Catheters Echocardiography Echocardiography, Transesophageal Electrosurgery - methods Female Follow-Up Studies Heart Heart Septum - diagnostic imaging Heart Septum - surgery Heart Valve Diseases - complications Heart Valve Diseases - diagnosis Heart Valve Diseases - surgery Heart Valve Prosthesis Implantation - methods Humans Intraoperative Period Laboratories Male Middle Aged mitral annular calcification Mitral valve Mitral Valve - diagnostic imaging Mitral Valve - surgery Mortality Prospective Studies structural heart disease Surgery Survival Tomography Tomography, X-Ray Computed transcatheter electrosurgery transcatheter mitral valve replacement transseptal interventions Treatment Outcome valve-in-ring Ventricle Ventricular Outflow Obstruction - diagnosis Ventricular Outflow Obstruction - etiology Ventricular Outflow Obstruction - prevention & control |
| Title | Anterior Leaflet Laceration to Prevent Ventricular Outflow Tract Obstruction During Transcatheter Mitral Valve Replacement |
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