Degenerative osteoarthritis a reversible chronic disease

Osteoarthritis (OA) is the most common chronic musculoskeletal disorder. It can affect any joint and is the most frequent single cause of disability in older adults. OA is a progressive degenerative disease involving the entire joint structure in a vicious circle that includes the capsule-bursa tiss...

Full description

Saved in:
Bibliographic Details
Published inRegenerative therapy Vol. 15; pp. 149 - 160
Main Author Di Nicola, V.
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 01.12.2020
Japanese Society for Regenerative Medicine
Elsevier
Subjects
Degenerative osteoarthritis
Early OA
MSCs
PRP
Review
Tissue Regeneration
Early OA
Tissue Regeneration
MSCs
Degenerative osteoarthritis
PRP
Online AccessGet full text

Cover

Abstract Osteoarthritis (OA) is the most common chronic musculoskeletal disorder. It can affect any joint and is the most frequent single cause of disability in older adults. OA is a progressive degenerative disease involving the entire joint structure in a vicious circle that includes the capsule-bursa tissue inflammation, synovial fluid modifications, cartilage breakdown and erosions, osteochondral inflammatory damage leading to bone erosion and distortion. Research has identified the initial inflammatory-immunologic process that starts this vicious cycle leading to so-called early OA. Research has also identified the role played in the disease advancement by synoviocytes type A and B, chondrocytes, extracellular matrix, local immune-inflammatory mediators and proteases. This article investigates the joint-resident MSCs that play an essential local homeostatic role and regulate cell turn over and tissue repair. Resident MSCs establish and maintain a local regenerative microenvironment. The understanding of OA physiopathology clarifies the core mechanisms by which minimally invasive interventions might be able to halt and reverse the course of early stage OA. Interventions employing PRP, MSCs and exosomes are considered in this article.
AbstractList Osteoarthritis (OA) is the most common chronic musculoskeletal disorder. It can affect any joint and is the most frequent single cause of disability in older adults. OA is a progressive degenerative disease involving the entire joint structure in a vicious circle that includes the capsule-bursa tissue inflammation, synovial fluid modifications, cartilage breakdown and erosions, osteochondral inflammatory damage leading to bone erosion and distortion. Research has identified the initial inflammatory-immunologic process that starts this vicious cycle leading to so-called early OA. Research has also identified the role played in the disease advancement by synoviocytes type A and B, chondrocytes, extracellular matrix, local immune-inflammatory mediators and proteases. This article investigates the joint-resident MSCs that play an essential local homeostatic role and regulate cell turn over and tissue repair. Resident MSCs establish and maintain a local regenerative microenvironment. The understanding of OA physiopathology clarifies the core mechanisms by which minimally invasive interventions might be able to halt and reverse the course of early stage OA. Interventions employing PRP, MSCs and exosomes are considered in this article.Osteoarthritis (OA) is the most common chronic musculoskeletal disorder. It can affect any joint and is the most frequent single cause of disability in older adults. OA is a progressive degenerative disease involving the entire joint structure in a vicious circle that includes the capsule-bursa tissue inflammation, synovial fluid modifications, cartilage breakdown and erosions, osteochondral inflammatory damage leading to bone erosion and distortion. Research has identified the initial inflammatory-immunologic process that starts this vicious cycle leading to so-called early OA. Research has also identified the role played in the disease advancement by synoviocytes type A and B, chondrocytes, extracellular matrix, local immune-inflammatory mediators and proteases. This article investigates the joint-resident MSCs that play an essential local homeostatic role and regulate cell turn over and tissue repair. Resident MSCs establish and maintain a local regenerative microenvironment. The understanding of OA physiopathology clarifies the core mechanisms by which minimally invasive interventions might be able to halt and reverse the course of early stage OA. Interventions employing PRP, MSCs and exosomes are considered in this article.
Osteoarthritis ( OA ) is the most common chronic musculoskeletal disorder. It can affect any joint and is the most frequent single cause of disability in older adults. OA is a progressive degenerative disease involving the entire joint structure in a vicious circle that includes the capsule-bursa tissue inflammation, synovial fluid modifications, cartilage breakdown and erosions, osteochondral inflammatory damage leading to bone erosion and distortion. Research has identified the initial inflammatory-immunologic process that starts this vicious cycle leading to so-called early OA. Research has also identified the role played in the disease advancement by synoviocytes type A and B , chondrocytes, extracellular matrix, local immune-inflammatory mediators and proteases. This article investigates the joint-resident MSCs that play an essential local homeostatic role and regulate cell turn over and tissue repair. Resident MSCs establish and maintain a local regenerative microenvironment . The understanding of OA physiopathology clarifies the core mechanisms by which minimally invasive interventions might be able to halt and reverse the course of early stage OA . Interventions employing PRP , MSCs and exosomes are considered in this article.
Osteoarthritis ( ) is the most common chronic musculoskeletal disorder. It can affect any joint and is the most frequent single cause of disability in older adults. is a progressive degenerative disease involving the entire joint structure in a vicious circle that includes the capsule-bursa tissue inflammation, synovial fluid modifications, cartilage breakdown and erosions, osteochondral inflammatory damage leading to bone erosion and distortion. Research has identified the initial inflammatory-immunologic process that starts this vicious cycle leading to so-called Research has also identified the role played in the disease advancement by synoviocytes and , chondrocytes, extracellular matrix, local immune-inflammatory mediators and proteases. This article investigates the joint-resident that play an essential local homeostatic role and regulate cell turn over and tissue repair. Resident establish and maintain a local . The understanding of physiopathology clarifies the core mechanisms by which minimally invasive interventions might be able to halt and reverse the course of early stage . Interventions employing , and are considered in this article.
Osteoarthritis (OA) is the most common chronic musculoskeletal disorder. It can affect any joint and is the most frequent single cause of disability in older adults.OA is a progressive degenerative disease involving the entire joint structure in a vicious circle that includes the capsule-bursa tissue inflammation, synovial fluid modifications, cartilage breakdown and erosions, osteochondral inflammatory damage leading to bone erosion and distortion.Research has identified the initial inflammatory-immunologic process that starts this vicious cycle leading to so-called early OA. Research has also identified the role played in the disease advancement by synoviocytes type A and B, chondrocytes, extracellular matrix, local immune-inflammatory mediators and proteases.This article investigates the joint-resident MSCs that play an essential local homeostatic role and regulate cell turn over and tissue repair. Resident MSCs establish and maintain a local regenerative microenvironment.The understanding of OA physiopathology clarifies the core mechanisms by which minimally invasive interventions might be able to halt and reverse the course of early stage OA. Interventions employing PRP, MSCs and exosomes are considered in this article.
Osteoarthritis (OA) is the most common chronic musculoskeletal disorder. It can affect any joint and is the most frequent single cause of disability in older adults. OA is a progressive degenerative disease involving the entire joint structure in a vicious circle that includes the capsule-bursa tissue inflammation, synovial fluid modifications, cartilage breakdown and erosions, osteochondral inflammatory damage leading to bone erosion and distortion. Research has identified the initial inflammatory-immunologic process that starts this vicious cycle leading to so-called early OA. Research has also identified the role played in the disease advancement by synoviocytes type A and B, chondrocytes, extracellular matrix, local immune-inflammatory mediators and proteases. This article investigates the joint-resident MSCs that play an essential local homeostatic role and regulate cell turn over and tissue repair. Resident MSCs establish and maintain a local regenerative microenvironment. The understanding of OA physiopathology clarifies the core mechanisms by which minimally invasive interventions might be able to halt and reverse the course of early stage OA. Interventions employing PRP, MSCs and exosomes are considered in this article.
Author Di Nicola, V.
Author_xml – sequence: 1
  givenname: V.
  orcidid: 0000-0003-2800-3433
  surname: Di Nicola
  fullname: Di Nicola, V.
  email: dinicolavalerio@gmail.com
  organization: West Sussex Hospitals NHS Foundation Trust, Worthing Hospital, BN112DH, UK
BackLink https://www.ncbi.nlm.nih.gov/pubmed/33426213$$D View this record in MEDLINE/PubMed
BookMark eNp9kU9vEzEQxS1URP_QL8AB7ZFLwnjsXW8khIQKhUqVuMDZ8trjxNFmXWwnEt8eL2lRy6Enjzzzfm8075ydTHEixt5wWHLg3fvtMlHZLBEQlqCWAOoFO0PR4kIgyJNH9Sm7zHkLALxvOa76V-xUCIkdcnHG-s-0pomSKeFATcyFokllk0IJuTFNogOlHIaRGrtJcQq2cSGTyfSavfRmzHR5_16wn9dfflx9W9x-_3pz9el2YVvZloW10poe0ax6IR0N6C2icg686cFI49wgB96Rws6rjryRztmVxFrj4LwQF-zmyHXRbPVdCjuTfutogv77EdNa14WDHUkrO1ReJ7yXVvacVwM0Q-da34p2AF9ZH4-su_2wI2dpKsmMT6BPO1PY6HU8aKUUCAkV8O4ekOKvPeWidyFbGkczUdxnjVJ1fQso5r3fPvb6Z_Jw-jrQHwdsijkn8tqGUmOIs3UYNQc9B623eg5az0FrULoGXaX4n_SB_qzow1FENa1DoKSzDTRZciGRLfWc4Tn5H6Tgw6s
CitedBy_id crossref_primary_10_1016_j_gene_2023_147920
crossref_primary_10_3390_ani11113247
crossref_primary_10_31718_2077_1096_24_4_241
crossref_primary_10_1007_s43465_023_00981_9
crossref_primary_10_3390_biomedicines10020306
crossref_primary_10_3892_etm_2023_12164
crossref_primary_10_1186_s13075_022_02747_4
crossref_primary_10_1155_2022_1900403
crossref_primary_10_2147_JPR_S357284
crossref_primary_10_1016_j_reth_2022_06_003
crossref_primary_10_33590_emjradiol__HHEU2045
crossref_primary_10_3389_fmed_2023_1204144
crossref_primary_10_1016_j_ijbiomac_2024_131505
crossref_primary_10_1016_j_gene_2023_147337
crossref_primary_10_3389_fmed_2023_1208326
crossref_primary_10_1155_2021_5499450
crossref_primary_10_1016_j_mad_2021_111539
crossref_primary_10_3390_ijms221910197
crossref_primary_10_1002_EXP_20220132
crossref_primary_10_4252_wjsc_v13_i11_1696
crossref_primary_10_4252_wjsc_v13_i11_1699
crossref_primary_10_3390_antiox11061113
crossref_primary_10_3389_fimmu_2023_1284609
crossref_primary_10_1002_advs_202207490
crossref_primary_10_3390_nu16010112
crossref_primary_10_3390_cells12141821
crossref_primary_10_3390_cells11060965
crossref_primary_10_1016_j_phymed_2023_154939
crossref_primary_10_20935_AcadBiol6147
crossref_primary_10_3892_etm_2021_10896
crossref_primary_10_3724_abbs_2023223
crossref_primary_10_3390_biomedicines12122812
crossref_primary_10_3390_jcm14051441
crossref_primary_10_3390_life14091149
crossref_primary_10_1007_s10142_022_00892_2
crossref_primary_10_3390_antiox11061209
crossref_primary_10_3389_fmolb_2021_686763
crossref_primary_10_4103_1735_5362_371581
crossref_primary_10_1016_j_lfs_2023_121741
crossref_primary_10_1007_s40778_023_00223_6
crossref_primary_10_1016_j_ocarto_2022_100295
crossref_primary_10_4103_jehp_jehp_1628_22
crossref_primary_10_3390_antiox13040386
crossref_primary_10_3390_jcm13041141
crossref_primary_10_1155_2022_7956167
crossref_primary_10_3390_biomedicines13030570
crossref_primary_10_1186_s40634_022_00516_5
crossref_primary_10_1038_s41598_023_38591_y
crossref_primary_10_1038_s41368_022_00187_z
crossref_primary_10_1126_sciadv_adi5501
crossref_primary_10_1007_s41669_024_00541_3
crossref_primary_10_3390_ijms241914895
crossref_primary_10_1007_s40883_022_00287_6
crossref_primary_10_1016_j_tice_2025_102851
crossref_primary_10_1021_acsanm_4c00657
crossref_primary_10_1016_j_prmcm_2022_100164
Cites_doi 10.1002/art.34453
10.1093/rheumatology/keq373
10.1038/nrrheum.2014.162
10.1007/s12015-018-9800-6
10.1002/art.30137
10.1038/s41598-020-67099-y
10.1136/rmdopen-2015-000062
10.1038/nrrheum.2010.159
10.1186/ar3555
10.1038/mt.2009.62
10.3899/jrheum.100637
10.1089/scd.2008.0358
10.1038/cddis.2015.327
10.1038/nm.2543
10.2217/rme.11.35
10.1002/art.21373
10.1016/j.joca.2013.07.017
10.1038/nature01323
10.1155/2016/9682757
10.21037/aoj.2019.09.02
10.1007/s00018-016-2293-z
10.3109/08820538.2011.570849
10.1016/S1063-4584(07)61536-2
10.1002/art.30471
10.1186/s13075-019-2050-4
10.1016/j.stemcr.2013.06.006
10.1016/j.stem.2009.06.013
10.1097/BOR.0b013e3283103d12
10.1016/j.yexcr.2004.12.013
10.1016/j.matbio.2014.08.008
10.1002/jcb.20886
10.1161/01.RES.0000265074.83288.09
10.1189/jlb.1AB0416-188RR
10.1038/nrrheum.2014.157
10.1038/mt.2015.44
10.1016/j.joca.2016.06.022
10.1002/jcp.22274
10.1093/rheumatology/32.8.671
10.1016/j.semcdb.2015.03.001
10.1083/jcb.14.2.207
10.1111/j.1749-6632.2009.05240.x
10.1002/art.21212
10.1002/jcp.20238
10.4252/wjsc.v11.i4.222
10.1016/j.joca.2010.08.016
10.1016/j.joca.2005.01.005
10.1089/wound.2012.0420
10.1016/j.joca.2012.09.018
10.1002/art.1780351010
10.1038/s41598-019-47391-2
10.1155/2015/542502
10.1002/art.11365
10.1016/j.joca.2003.08.004
10.1016/j.yjmcc.2009.12.021
10.1016/j.febslet.2015.03.031
10.1097/BOR.0b013e32830aba34
10.1007/s00109-007-0258-2
10.1074/jbc.M100099200
10.1016/j.tvjl.2007.08.013
10.1002/1529-0131(200108)44:8<1928::AID-ART331>3.0.CO;2-P
10.1007/s00167-011-1743-2
10.1172/jci.insight.125325
10.1186/s13287-019-1359-x
10.1002/art.34315
10.1186/s13018-016-0359-0
10.1093/rheumatology/kev228
10.1007/s12015-014-9567-3
10.1089/ten.tec.2008.0534
10.1186/s12891-016-1085-9
10.1186/1479-5876-7-29
10.1016/j.arthro.2012.11.017
10.1186/ar2592
10.1016/j.stem.2011.06.008
10.1136/bjsports-2014-094036
10.1136/ard.2011.150243
10.1136/ard.2004.025270
10.1016/j.joca.2008.08.007
10.1016/j.exphem.2004.02.004
10.1016/j.joca.2005.07.014
10.7150/thno.17133
10.1002/art.27290
10.1002/jor.20498
10.1097/BOR.0b013e3283432d1f
10.1634/stemcells.2006-0311
10.1007/s00167-016-4068-3
10.1002/jor.22005
10.1016/j.joca.2008.06.025
10.1007/s11926-017-0672-6
10.1016/j.biomaterials.2012.06.058
10.4049/jimmunol.149.4.1424
10.4081/or.2014.5405
10.1016/j.stem.2008.08.008
10.2174/18746098112059990029
10.1007/s11999-010-1764-z
10.1097/BOR.0000000000000479
10.2174/1874312901105010100
10.1002/jor.22671
10.1177/2040622319825567
10.1016/j.semcdb.2016.11.008
10.5312/wjo.v5.i3.351
10.1002/art.11094
10.1007/s00167-015-3705-6
10.1177/1759720X12467868
10.1038/ni.1863
10.1073/pnas.0510511103
10.1002/art.21779
10.4081/or.2019.7747
10.1016/j.cell.2007.08.025
10.1093/rheumatology/keh344
10.2217/rme-2016-0077
ContentType Journal Article
Copyright 2020 The Japanese Society for Regenerative Medicine
2020 The Japanese Society for Regenerative Medicine. Production and hosting by Elsevier B.V.
2020 The Japanese Society for Regenerative Medicine. Production and hosting by Elsevier B.V. 2020 The Japanese Society for Regenerative Medicine
Copyright_xml – notice: 2020 The Japanese Society for Regenerative Medicine
– notice: 2020 The Japanese Society for Regenerative Medicine. Production and hosting by Elsevier B.V.
– notice: 2020 The Japanese Society for Regenerative Medicine. Production and hosting by Elsevier B.V. 2020 The Japanese Society for Regenerative Medicine
DBID 6I.
AAFTH
AAYXX
CITATION
NPM
7X8
5PM
DOA
DOI 10.1016/j.reth.2020.07.007
DatabaseName ScienceDirect Open Access Titles
Elsevier:ScienceDirect:Open Access
CrossRef
PubMed
MEDLINE - Academic
PubMed Central (Full Participant titles)
DOAJ Directory of Open Access Journals
DatabaseTitle CrossRef
PubMed
MEDLINE - Academic
DatabaseTitleList MEDLINE - Academic

PubMed
Database_xml – sequence: 1
  dbid: DOA
  name: DOAJ Directory of Open Access Journals
  url: https://www.doaj.org/
  sourceTypes: Open Website
– sequence: 2
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
DeliveryMethod fulltext_linktorsrc
Discipline Anatomy & Physiology
EISSN 2352-3204
EndPage 160
ExternalDocumentID oai_doaj_org_article_7cbadd63ff4c481180a2ab6d5f535b0f
PMC7770340
33426213
10_1016_j_reth_2020_07_007
S2352320420300651
Genre Journal Article
Review
GroupedDBID 0R~
0SF
4.4
457
53G
5VS
6I.
AACTN
AAEDW
AAFTH
AAIKJ
AALRI
AAXUO
ABMAC
ACGFS
ADBBV
ADEZE
AEXQZ
AFTJW
AGHFR
AITUG
ALMA_UNASSIGNED_HOLDINGS
AMRAJ
AOIJS
BCNDV
EBS
EJD
FDB
GROUPED_DOAJ
HYE
HZ~
IPNFZ
KQ8
M41
M~E
NCXOZ
O9-
OK1
RIG
ROL
RPM
SSZ
AAYWO
AAYXX
ACVFH
ADCNI
ADVLN
AEUPX
AFJKZ
AFPUW
AIGII
AKBMS
AKRWK
AKYEP
APXCP
CITATION
NPM
7X8
5PM
ID FETCH-LOGICAL-c545t-cc4ca822a9834deb2fc227dd0fa80a4addb4b16e726f76efa4ddc94276e2bdf33
IEDL.DBID DOA
ISSN 2352-3204
IngestDate Wed Aug 27 01:26:44 EDT 2025
Thu Aug 21 13:52:39 EDT 2025
Fri Jul 11 00:37:47 EDT 2025
Thu Jan 02 22:57:34 EST 2025
Thu Apr 24 23:08:51 EDT 2025
Tue Jul 01 03:44:11 EDT 2025
Fri Feb 23 02:47:53 EST 2024
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Keywords Early OA
Tissue Regeneration
MSCs
Degenerative osteoarthritis
PRP
Language English
License This is an open access article under the CC BY-NC-ND license.
2020 The Japanese Society for Regenerative Medicine. Production and hosting by Elsevier B.V.
This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c545t-cc4ca822a9834deb2fc227dd0fa80a4addb4b16e726f76efa4ddc94276e2bdf33
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Review-3
content type line 23
ORCID 0000-0003-2800-3433
OpenAccessLink https://doaj.org/article/7cbadd63ff4c481180a2ab6d5f535b0f
PMID 33426213
PQID 2476850233
PQPubID 23479
PageCount 12
ParticipantIDs doaj_primary_oai_doaj_org_article_7cbadd63ff4c481180a2ab6d5f535b0f
pubmedcentral_primary_oai_pubmedcentral_nih_gov_7770340
proquest_miscellaneous_2476850233
pubmed_primary_33426213
crossref_citationtrail_10_1016_j_reth_2020_07_007
crossref_primary_10_1016_j_reth_2020_07_007
elsevier_sciencedirect_doi_10_1016_j_reth_2020_07_007
ProviderPackageCode CITATION
AAYXX
PublicationCentury 2000
PublicationDate 2020-12-01
PublicationDateYYYYMMDD 2020-12-01
PublicationDate_xml – month: 12
  year: 2020
  text: 2020-12-01
  day: 01
PublicationDecade 2020
PublicationPlace Netherlands
PublicationPlace_xml – name: Netherlands
PublicationTitle Regenerative therapy
PublicationTitleAlternate Regen Ther
PublicationYear 2020
Publisher Elsevier B.V
Japanese Society for Regenerative Medicine
Elsevier
Publisher_xml – name: Elsevier B.V
– name: Japanese Society for Regenerative Medicine
– name: Elsevier
References Baloch, Hasan, Zain Baig, Atif, Ohuchi (bib116) 2019 Sep 24; 11
Nakamura, Miyaki, Ishitobi, Matsuyama, Nakasa, Kamei (bib36) 2015 May 8; 589
Lehner, Koeck, Capellino, Schubert, Hofbauer, Straub (bib70) 2008; 26
Nakagawa, Sasho, Arai, Ogino, Wada, Moriya (bib109) 2007; 15
Aigner, Schmitz (bib54) 2011
Morales-Ducret, Wayner, Elices, Alvaro-Gracia, Zvaifler, Firestein (bib12) 1992; 149
Makris, Gomoll, Malizos, Hu, Athanasiou (bib119) 2015; 11
Prockop (bib18) 2009; 17
Telander (bib89) 2011; 26
Koeck, Schmitt, Baier, Stangl, Beckmann, Grifka (bib71) 2016; 11
Yen, Yen, Hsu, Liu, Wang, Bai (bib26) 2013 Jul 25; 1
Tarafder, Lee (bib45) 2016
Hasegawa, Segawa, Maeda (bib81) 2011; 38
Murphy, Fink, Hunziker, Barry (bib129) 2003; 48
Marmotti, Rossi, Castoldi, Roveda, Michielon, Peretti (bib111) 2015; 2015
Di Nicola, Pierpaoli (bib43) 2013 Jul; 6
Wilkinson, Pitsillides, Worrall, Edwards (bib10) 1992; 35
Smith (bib8) 2011; 5
Kalaitzoglou, Griffin, Humphrey (bib85) 2017; 19
Mifune, Matsumoto, Takayama, Ota, Li, Meszaros (bib106) 2013; 21
Roemer, Guermazi, Felson, Niu, Nevitt, Crema (bib62) 2011; 70
Xie, Wang, Zhao, Guo, Liu, Jia (bib126) 2012; 33
Koh, Jo, Kwon, Suh, Lee, Park (bib125) 2013; 29
Pritzker, Gay, Jimenez, Ostergaard, Pelletier, Revell (bib68) 2006; 14
.
Rasmusson, Ringdén, Sundberg, Le Blanc (bib25) 2005 Apr 15; 305
Russell, Watad, Bridgewood, Khan, Millner, Loughenbury (bib42) 2019; 78
Di Nicola (bib120) 2019; 11
Laudy, Bakker, Rekers, Moen (bib103) 2015; 49
Liu-Bryan, Terkeltaub (bib96) 2015 Jan; 11
Jay, Waller (bib7) 2014; 39
Ayhan, Kesmezacar, Akgun (bib100) 2014; 5
Van Lent, Blom, Schelbergen, Sloetjes, Lafeber, Lems (bib97) 2012; 64
Brandt, Dieppe, Radin (bib75) 2009; 93
(bib2) 2004
Sohn, Sokolove, Sharpe, Erhart, Chandra, Lahey (bib95) 2012; 14
Bielli, Scioli, Gentile, Cervelli, Orlandi (bib130) 2016; 11
Zhang, Chu, Lai, Lim, Hui, Toh (bib37) 2016 Dec; 24
Gerhardt, Semb (bib22) 2008; 86
Sellam, Berenbaum (bib67) 2010; 6
Maumus, Pers, Ruiz, Jorgensen, Noël (bib132) 2018; 34
Loeser, Goldring, Scanzello, Goldring (bib87) 2012 Jun; 64
Di Nicola, Di Nicola (bib138) 2012; 5
Young, James, Lowe, MedSci Bmbs, Stevens, Heath (bib5) 2006
Freitag, Bates, Boyd, Shah, Barnard, Huguenin (bib124) 2016; 17
Scanzello, McKeon, Swaim, DiCarlo, Asomugha, Kanda (bib65) 2011; 63
Javazon, Begges, Flake (bib17) 2004; 32
Kaeley, Bakewell, Deodhar (bib139) 2020; 22
Farr, Cole, Dhawan, Kercher, Sherman (bib118) 2011; 469
Bonnet, Walsh (bib84) 2005; 44
Scanzello, Plaas, Crow (bib91) 2008; 20
Caplan (bib20) 2008; 3
Estes, Wu, Guilak (bib31) 2006 Apr; 54
Rani, Ryan, Griffin, Ritter (bib35) 2015 May; 23
Wang, Rozelle, Lepus, Scanzello, Song, Larsen (bib99) 2011; 17
Pittenger (bib133) 2009; 5
Gao, Chiu, Motan, Zhang, Chen, Ji (bib23) 2016 Jan 21; 7
Sokolove, Lepus (bib49) 2013 Apr; 5
Caplan, Correa (bib19) 2011; 9
Madry, Kon, Condello, Peretti, Steinwachs, Seil (bib57) 2016; 24
WHO Department of Chronic Diseases and Health Promotion.
Goldring (bib55) 2010; 1192
Mishra, Tummala, King, Lee, Kraus, Tse (bib104) 2009; 15
Najar, Raicevic, Crompot, Fayyad-Kazan, Bron, Toungouz (bib24) 2016 Feb-Mar; 39
Knight, Hankenson (bib44) 2013 Jul; 2
Iwashima, Ozaki, Maruyama, Saka, Kobori, Omae (bib121) 2009; 18
Caplan, Dennis (bib29) 2006; 98
Favero, Ramonda, Goldring, Goldring, Punzi (bib69) 2015; 1
Spees, Olson, Whitney, Prockop (bib123) 2006; 103
Krasnokutsky, Belitskaya-Levy, Bencardino, Samuels, Attur, Regatte (bib61) 2011; 63
Säämänen, Arokoski, Jurvelin, Kiviranta (bib46) 2010
Gimble, Katz, Bunnell (bib127) 2007 May 11; 100
De Bari, Dell'Accio, Tylzanowski, Luyten (bib13) 2001; 44
Riordan, Ichim, Min, Wang, Solano, Lara (bib122) 2009; 7
Sakaguchi, Sekiya, Yagishita, Muneta (bib14) 2005; 52
Hu, He, Ma, Wang, Cui, Hu (bib41) 2018
Gross, Guillaume, Gegout-Pottie, Reboul, Jouzeau, Mainard (bib86) 2017; 35
Rothrauff, Pirosa, Lin, Sohn, Langhans, Tuan (bib117) 2019
Krüger, Hondke, Endres, Pruss, Siclari, Kaps (bib105) 2011; 30
Huang, Wang, Wu, Jiang, Hu, Pei (bib110) 2009; 122
Sacchetti, Funari, Michienzi, Di Cesare, Piersanti, Saggio (bib21) 2007 Oct 19; 131
Kouroupis, Bowles, Willman, Perucca Orfei, Colombini, Best (bib38) 2019 Jul 26; 9
Haywood, McWilliams, Pearson, Gill, Ganesan, Wilson (bib66) 2003; 48
Wise (bib51) 2010
Kanamoto, Mae, Yokoyama, Tanaka, Ebina, Nakata (bib58) 2020; 5
Buckwalter, Mankin, Grodzinsky (bib53) 2005; 54
Yuan, Tanaka, Masuko-Hongo (bib79) 2004; 12
Libby (bib88) 2002; 420
Lee, Hui, Song, Ardany, Lee (bib128) 2007; 25
Vina, Kwoh (bib60) 2018; 30
Loeuille, Chary-Valckenaere, Champigneulle (bib78) 2005; 52
O'Shaughnessey, Matuska, Hoeppner, Farr, Klaassen, Kaeding (bib113) 2014; 32
Ayral, Pickering, Woodworth, Mackillop, Dougados (bib64) 2005; 13
Krasnokutsky, Attur, Palmer (bib82) 2008; 16
Martel-Pelletier, Pelletier (bib48) 2010; 21
Lai, Arslan, Tan, Tan, Choo, Lee (bib34) 2010 Jun; 48
Caplan (bib28) 2019
Lee, Ort, Ma (bib80) 2009; 17
Tao, Yuan, Zhang, Yin, Guo, Zhang (bib136) 2017; 7
Rosenthal (bib98) 2011; 23
Toh, Lai, Hui, Lim (bib135) 2017; 67
Dean, Hoyland, Denton, Donn, Freemont (bib74) 1993; 32
Okamura, Watari, Jerud, Young, Ishizaka, Rose (bib94) 2001; 276
Gazit, Pelled, Sheyn, Yacubovich, Gazit (bib16) 2019
Seidman, Limaiem (bib6) Jan 22, 2019
Zhu, Yuan, Meng, Wang, Guo, Wang (bib101) 2013; 21
Tangchitphisut, Srikaew, Numhom, Tangprasittipap, Woratanarat, Wongsak (bib39) 2016
Barland, Novikoff, Hamerman (bib9) 1962; 14
Sutton, Clutterbuck, Harris (bib59) 2009; 179
Kawai, Akira (bib93) 2010; 11
Li, Chen, Wang, Zeng (bib32) 2016; 2016
Lai, Chen, Lim (bib134) 2011; 6
Dieppe (bib47) 2011; 50
Remst, Blaney Davidson, van der Kraan (bib92) 2015; 54
Lai, Yeo, Lim (bib33) 2015 Apr; 40
Ashraf, Walsh (bib83) 2008; 20
Wasai, Sato, Maehara, Toyoda, Uchiyama, Takahashi (bib114) 2020; 10
Camernik, Barlic, Drobnic, Marc, Jeras, Zupan (bib15) 2018; 14
Wyss-Coray (bib90) 2006; 12
Wood, Leckenby, Reynolds, Spiering, Pratt, Rankin (bib77) 2019; 4
Li, Tang, Song, Yu, Li, Zhang (bib4) 2019; 10
Najar, Raicevic, Fayyad-Kazan, De Bruyn, Bron, Toungouz (bib27) 2015 Jun; 11
Wang, Feng, Jia, Zhao, Yu (bib131) 2019; 11
Bendinelli, Matteucci, Dogliotti, Corsi, Banfi, Maroni (bib107) 2010; 225
Luyten, Denti, Filardo, Kon, Engebretsen (bib56) 2012; 20
Goldring, Marcu (bib50) 2009; 11
Stannus, Jones, Cicuttini (bib52) 2010; 18
Mora, Przkora, Cruz-Almeida (bib137) 2018; 11
Bondeson, Blom, Wainwright, Hughes, Caterson, Van Den Berg (bib73) 2010; 62
Rayegani, Raeissadat, Sanei Taheri, Babaee, Rayegani, Eliaspour (bib102) 2014; 6
Solchaga, Penick, Porter, Goldberg, Caplan, Welter (bib30) 2005 May; 203
Mashaghi, Marmalidou, Tehrani, Grace, Pothoulakis, Dana (bib40) 2016 Nov; 73
Spitsin, Meshki, Winters, Tuluc, Benton, Douglas (bib72) 2017; 101
Kilian, Flesch, Wenisch, Taborski, Jork, Schnettler (bib108) 2004; 9
Pitsillides, Wilkinson, Mehdizadeh, Bayliss, Edwards (bib11) 1993; 74
Benito, Veale, FitzGerald, van den Berg, Bresnihan (bib76) 2005; 64
Gato-Calvo, Magalhaes, Ruiz-Romero, Blanco, Burguera (bib115) 2019
(bib3) 2013
Di Nicola, Di Pietrantonio (bib63) 2016; 1
Görmeli, Görmeli, Ataoglu, Çolak, Aslantürk, Ertem (bib112) 2017; 25
Sokolove (10.1016/j.reth.2020.07.007_bib49) 2013; 5
Kilian (10.1016/j.reth.2020.07.007_bib108) 2004; 9
Rasmusson (10.1016/j.reth.2020.07.007_bib25) 2005; 305
Aigner (10.1016/j.reth.2020.07.007_bib54) 2011
Spitsin (10.1016/j.reth.2020.07.007_bib72) 2017; 101
Makris (10.1016/j.reth.2020.07.007_bib119) 2015; 11
Ayhan (10.1016/j.reth.2020.07.007_bib100) 2014; 5
Ashraf (10.1016/j.reth.2020.07.007_bib83) 2008; 20
Kanamoto (10.1016/j.reth.2020.07.007_bib58) 2020; 5
Favero (10.1016/j.reth.2020.07.007_bib69) 2015; 1
Lee (10.1016/j.reth.2020.07.007_bib128) 2007; 25
10.1016/j.reth.2020.07.007_bib1
Loeser (10.1016/j.reth.2020.07.007_bib87) 2012; 64
Gazit (10.1016/j.reth.2020.07.007_bib16) 2019
Bielli (10.1016/j.reth.2020.07.007_bib130) 2016; 11
Barland (10.1016/j.reth.2020.07.007_bib9) 1962; 14
Roemer (10.1016/j.reth.2020.07.007_bib62) 2011; 70
Iwashima (10.1016/j.reth.2020.07.007_bib121) 2009; 18
Spees (10.1016/j.reth.2020.07.007_bib123) 2006; 103
Pritzker (10.1016/j.reth.2020.07.007_bib68) 2006; 14
Caplan (10.1016/j.reth.2020.07.007_bib19) 2011; 9
Wood (10.1016/j.reth.2020.07.007_bib77) 2019; 4
Morales-Ducret (10.1016/j.reth.2020.07.007_bib12) 1992; 149
Haywood (10.1016/j.reth.2020.07.007_bib66) 2003; 48
Nakagawa (10.1016/j.reth.2020.07.007_bib109) 2007; 15
(10.1016/j.reth.2020.07.007_bib3) 2013
Libby (10.1016/j.reth.2020.07.007_bib88) 2002; 420
Wasai (10.1016/j.reth.2020.07.007_bib114) 2020; 10
Farr (10.1016/j.reth.2020.07.007_bib118) 2011; 469
Riordan (10.1016/j.reth.2020.07.007_bib122) 2009; 7
Kaeley (10.1016/j.reth.2020.07.007_bib139) 2020; 22
Buckwalter (10.1016/j.reth.2020.07.007_bib53) 2005; 54
Koh (10.1016/j.reth.2020.07.007_bib125) 2013; 29
Young (10.1016/j.reth.2020.07.007_bib5) 2006
Mora (10.1016/j.reth.2020.07.007_bib137) 2018; 11
Li (10.1016/j.reth.2020.07.007_bib4) 2019; 10
Baloch (10.1016/j.reth.2020.07.007_bib116) 2019; 11
Madry (10.1016/j.reth.2020.07.007_bib57) 2016; 24
Koeck (10.1016/j.reth.2020.07.007_bib71) 2016; 11
Seidman (10.1016/j.reth.2020.07.007_bib6) 2019
Benito (10.1016/j.reth.2020.07.007_bib76) 2005; 64
Rani (10.1016/j.reth.2020.07.007_bib35) 2015; 23
Görmeli (10.1016/j.reth.2020.07.007_bib112) 2017; 25
Hu (10.1016/j.reth.2020.07.007_bib41) 2018
Sellam (10.1016/j.reth.2020.07.007_bib67) 2010; 6
Nakamura (10.1016/j.reth.2020.07.007_bib36) 2015; 589
Krasnokutsky (10.1016/j.reth.2020.07.007_bib61) 2011; 63
Okamura (10.1016/j.reth.2020.07.007_bib94) 2001; 276
Van Lent (10.1016/j.reth.2020.07.007_bib97) 2012; 64
Wilkinson (10.1016/j.reth.2020.07.007_bib10) 1992; 35
Zhu (10.1016/j.reth.2020.07.007_bib101) 2013; 21
Goldring (10.1016/j.reth.2020.07.007_bib55) 2010; 1192
Bendinelli (10.1016/j.reth.2020.07.007_bib107) 2010; 225
Di Nicola (10.1016/j.reth.2020.07.007_bib63) 2016; 1
Caplan (10.1016/j.reth.2020.07.007_bib29) 2006; 98
Dean (10.1016/j.reth.2020.07.007_bib74) 1993; 32
Bonnet (10.1016/j.reth.2020.07.007_bib84) 2005; 44
Gerhardt (10.1016/j.reth.2020.07.007_bib22) 2008; 86
Vina (10.1016/j.reth.2020.07.007_bib60) 2018; 30
Kouroupis (10.1016/j.reth.2020.07.007_bib38) 2019; 9
Rosenthal (10.1016/j.reth.2020.07.007_bib98) 2011; 23
Krüger (10.1016/j.reth.2020.07.007_bib105) 2011; 30
Scanzello (10.1016/j.reth.2020.07.007_bib65) 2011; 63
Xie (10.1016/j.reth.2020.07.007_bib126) 2012; 33
Smith (10.1016/j.reth.2020.07.007_bib8) 2011; 5
Tao (10.1016/j.reth.2020.07.007_bib136) 2017; 7
Tarafder (10.1016/j.reth.2020.07.007_bib45) 2016
Pittenger (10.1016/j.reth.2020.07.007_bib133) 2009; 5
Huang (10.1016/j.reth.2020.07.007_bib110) 2009; 122
Lehner (10.1016/j.reth.2020.07.007_bib70) 2008; 26
Lai (10.1016/j.reth.2020.07.007_bib33) 2015; 40
Krasnokutsky (10.1016/j.reth.2020.07.007_bib82) 2008; 16
Lai (10.1016/j.reth.2020.07.007_bib34) 2010; 48
Säämänen (10.1016/j.reth.2020.07.007_bib46) 2010
Maumus (10.1016/j.reth.2020.07.007_bib132) 2018; 34
Tangchitphisut (10.1016/j.reth.2020.07.007_bib39) 2016
Prockop (10.1016/j.reth.2020.07.007_bib18) 2009; 17
Javazon (10.1016/j.reth.2020.07.007_bib17) 2004; 32
Wang (10.1016/j.reth.2020.07.007_bib99) 2011; 17
Caplan (10.1016/j.reth.2020.07.007_bib28) 2019
Wise (10.1016/j.reth.2020.07.007_bib51) 2010
Toh (10.1016/j.reth.2020.07.007_bib135) 2017; 67
Yen (10.1016/j.reth.2020.07.007_bib26) 2013; 1
Li (10.1016/j.reth.2020.07.007_bib32) 2016; 2016
De Bari (10.1016/j.reth.2020.07.007_bib13) 2001; 44
Remst (10.1016/j.reth.2020.07.007_bib92) 2015; 54
Liu-Bryan (10.1016/j.reth.2020.07.007_bib96) 2015; 11
Solchaga (10.1016/j.reth.2020.07.007_bib30) 2005; 203
Brandt (10.1016/j.reth.2020.07.007_bib75) 2009; 93
Telander (10.1016/j.reth.2020.07.007_bib89) 2011; 26
Loeuille (10.1016/j.reth.2020.07.007_bib78) 2005; 52
Zhang (10.1016/j.reth.2020.07.007_bib37) 2016; 24
Stannus (10.1016/j.reth.2020.07.007_bib52) 2010; 18
Sutton (10.1016/j.reth.2020.07.007_bib59) 2009; 179
Gato-Calvo (10.1016/j.reth.2020.07.007_bib115) 2019
Sakaguchi (10.1016/j.reth.2020.07.007_bib14) 2005; 52
Mashaghi (10.1016/j.reth.2020.07.007_bib40) 2016; 73
Sacchetti (10.1016/j.reth.2020.07.007_bib21) 2007; 131
Ayral (10.1016/j.reth.2020.07.007_bib64) 2005; 13
Gimble (10.1016/j.reth.2020.07.007_bib127) 2007; 100
Najar (10.1016/j.reth.2020.07.007_bib27) 2015; 11
Mishra (10.1016/j.reth.2020.07.007_bib104) 2009; 15
Caplan (10.1016/j.reth.2020.07.007_bib20) 2008; 3
Laudy (10.1016/j.reth.2020.07.007_bib103) 2015; 49
Di Nicola (10.1016/j.reth.2020.07.007_bib43) 2013; 6
Lee (10.1016/j.reth.2020.07.007_bib80) 2009; 17
Russell (10.1016/j.reth.2020.07.007_bib42) 2019; 78
Lai (10.1016/j.reth.2020.07.007_bib134) 2011; 6
Freitag (10.1016/j.reth.2020.07.007_bib124) 2016; 17
Martel-Pelletier (10.1016/j.reth.2020.07.007_bib48) 2010; 21
Bondeson (10.1016/j.reth.2020.07.007_bib73) 2010; 62
Gross (10.1016/j.reth.2020.07.007_bib86) 2017; 35
Scanzello (10.1016/j.reth.2020.07.007_bib91) 2008; 20
Dieppe (10.1016/j.reth.2020.07.007_bib47) 2011; 50
Wyss-Coray (10.1016/j.reth.2020.07.007_bib90) 2006; 12
Mifune (10.1016/j.reth.2020.07.007_bib106) 2013; 21
Pitsillides (10.1016/j.reth.2020.07.007_bib11) 1993; 74
Goldring (10.1016/j.reth.2020.07.007_bib50) 2009; 11
Najar (10.1016/j.reth.2020.07.007_bib24) 2016; 39
Jay (10.1016/j.reth.2020.07.007_bib7) 2014; 39
Camernik (10.1016/j.reth.2020.07.007_bib15) 2018; 14
Murphy (10.1016/j.reth.2020.07.007_bib129) 2003; 48
Rothrauff (10.1016/j.reth.2020.07.007_bib117) 2019
Rayegani (10.1016/j.reth.2020.07.007_bib102) 2014; 6
Marmotti (10.1016/j.reth.2020.07.007_bib111) 2015; 2015
Kawai (10.1016/j.reth.2020.07.007_bib93) 2010; 11
Estes (10.1016/j.reth.2020.07.007_bib31) 2006; 54
Wang (10.1016/j.reth.2020.07.007_bib131) 2019; 11
Gao (10.1016/j.reth.2020.07.007_bib23) 2016; 7
O'Shaughnessey (10.1016/j.reth.2020.07.007_bib113) 2014; 32
Hasegawa (10.1016/j.reth.2020.07.007_bib81) 2011; 38
Yuan (10.1016/j.reth.2020.07.007_bib79) 2004; 12
Di Nicola (10.1016/j.reth.2020.07.007_bib138) 2012; 5
Kalaitzoglou (10.1016/j.reth.2020.07.007_bib85) 2017; 19
Sohn (10.1016/j.reth.2020.07.007_bib95) 2012; 14
(10.1016/j.reth.2020.07.007_bib2) 2004
Knight (10.1016/j.reth.2020.07.007_bib44) 2013; 2
Di Nicola (10.1016/j.reth.2020.07.007_bib120) 2019; 11
Luyten (10.1016/j.reth.2020.07.007_bib56) 2012; 20
References_xml – volume: 1192
  start-page: 230
  year: 2010
  end-page: 237
  ident: bib55
  article-title: Articular cartilage and subchondral bone in the pathogenesis of osteoarthritis
  publication-title: Ann NY Acad Sci
– year: 2004
  ident: bib2
  article-title: World population to 2300
– volume: 6
  start-page: 625
  year: 2010
  end-page: 635
  ident: bib67
  article-title: The role of synovitis in pathophysiology and clinical symptoms of osteoarthritis
  publication-title: Nat Rev Rheumatol
– volume: 62
  start-page: 647
  year: 2010
  end-page: 657
  ident: bib73
  article-title: The role of synovial macrophages and macrophage-produced mediators in driving inflammatory and destructive responses in osteoarthritis
  publication-title: Arthritis Rheum
– volume: 24
  start-page: 2135
  year: 2016 Dec
  end-page: 2140
  ident: bib37
  article-title: Exosomes derived from human embryonic mesenchymal stem cells promote osteochondral regeneration
  publication-title: Osteoarthritis Cartilage
– volume: 14
  start-page: 13
  year: 2006
  end-page: 29
  ident: bib68
  article-title: Osteoarthritis cartilage histopathology: grading and staging
  publication-title: Osteoarthritis Cartilage
– volume: 21
  start-page: 1627
  year: 2013
  end-page: 1637
  ident: bib101
  article-title: Basic science and clinical application of platelet -rich plasma for cartilage defects and osteoarthritis: a review
  publication-title: Osteoarthritis Cartilage
– volume: 22
  start-page: 1
  year: 2020
  ident: bib139
  article-title: The importance of ultrasound in identifying and differentiating patients with early inflammatory arthritis: a narrative review
  publication-title: Arthritis Res Ther
– volume: 5
  start-page: 351
  year: 2014
  end-page: 361
  ident: bib100
  article-title: Intraarticular injections (corticosteroid, hyaluronic acid, platelet rich plasma) for the knee osteoarthritis
  publication-title: World J Orthoped
– volume: 1
  start-page: 1006
  year: 2016
  ident: bib63
  article-title: MRI in degenerative joint disease (DJD): a proposal for imaging standardization in regenerative medicine
  publication-title: SM Musculoskelet Disord
– volume: 11
  start-page: 182-191
  year: 2019
  ident: bib120
  article-title: Omentum a powerful biological source in regenerative surgery
  publication-title: Regen Ther
– volume: 73
  start-page: 4249
  year: 2016 Nov
  end-page: 4264
  ident: bib40
  article-title: Neuropeptide substance P and the immune response
  publication-title: Cell Mol Life Sci
– start-page: 1741
  year: 2011
  end-page: 1759
  ident: bib54
  article-title: Pathogenesis and pathology of osteoarthritis
  publication-title: Rheumatology
– volume: 38
  start-page: 129
  year: 2011
  end-page: 134
  ident: bib81
  article-title: Thrombin-cleaved osteopontin levels in synovial fluid correlate with disease severity of knee osteoarthritis
  publication-title: J Rheumatol
– volume: 103
  start-page: 1283
  year: 2006
  end-page: 1288
  ident: bib123
  article-title: Mitochondrial transfer between cells can rescue aerobic respiration
  publication-title: Proc Natl Acad Sci U S A
– volume: 11
  start-page: 373
  year: 2010
  end-page: 384
  ident: bib93
  article-title: The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors
  publication-title: Nat Immunol
– volume: 17
  start-page: 939
  year: 2009
  end-page: 946
  ident: bib18
  article-title: Repair of tissues by adult/stem progenitor cells (MSCs): controversies, myths, and changing paradigsms
  publication-title: Mol Ther
– volume: 9
  start-page: 11
  year: 2011
  end-page: 15
  ident: bib19
  article-title: The MSCs: an injury drugstore
  publication-title: Cell Stem Cell
– volume: 11
  start-page: 2189-2196
  year: 2018
  ident: bib137
  article-title: Knee osteoarthritis: pathophysiology and current treatment modalities
  publication-title: J Pain Res
– volume: 34
  start-page: 1092
  year: 2018
  end-page: 1099
  ident: bib132
  article-title: Cellules souches mésenchymateuses et médecine régénératrice - quel avenir pour l’arthrose ? [Mesenchymal stem cells and regenerative medicine: future perspectives in osteoarthritis]
  publication-title: Med Sci
– volume: 33
  start-page: 7008
  year: 2012
  end-page: 7018
  ident: bib126
  article-title: Comparative evaluation of MSCs from bone marrow and adipose tissue seeded in PRP-derived scaffold for cartilage regeneration
  publication-title: Biomaterials
– volume: 35
  start-page: 53-60
  year: 2017
  ident: bib86
  article-title: The infrapatellar fat pad induces inflammatory and degradative effects in articular cells but not through leptin or adiponectin
  publication-title: Clin Exp Rheumatol
– volume: 305
  start-page: 33
  year: 2005 Apr 15
  end-page: 41
  ident: bib25
  article-title: Mesenchymal stem cells inhibit lymphocyte proliferation by mitogens and alloantigens by different mechanisms
  publication-title: Exp Cell Res
– year: Jan 22, 2019
  ident: bib6
  article-title: Synovial fluid analysis
– volume: 98
  start-page: 1076
  year: 2006
  end-page: 1084
  ident: bib29
  article-title: Mesenchymal stem cells as trophic mediators
  publication-title: J Cell Biochem
– volume: 16
  start-page: S1
  year: 2008
  end-page: S3
  ident: bib82
  article-title: Current concepts in the pathogenesis of osteoarthritis
  publication-title: Osteoarthritis Cartilage
– volume: 35
  start-page: 1179
  year: 1992
  end-page: 1184
  ident: bib10
  article-title: Light microscopic characterization of the fibroblast-like synovial intimal cell (synoviocyte)
  publication-title: Arthritis Rheum
– year: 2013
  ident: bib3
  publication-title: Junqueira's basic histology: text and atlas
– volume: 17
  start-page: 230
  year: 2016
  ident: bib124
  article-title: Mesenchymal stem cell therapy in the treatment of osteoarthritis: reparative pathways, safety and efficacy - a review
  publication-title: BMC Muscoskel Disord
– volume: 21
  start-page: 2
  year: 2010
  end-page: 14
  ident: bib48
  article-title: Is osteoarthritis a disease involving only cartilage or other articular tissues?
  publication-title: Eklem Hastalik Cerrahisi
– volume: 78
  start-page: 955
  year: 2019
  ident: bib42
  article-title: FRI0520 The human enthesis contains populations of Mesenchymal stem cells with distinct functional characteristics
  publication-title: Ann Rheum Dis
– volume: 122
  start-page: 83-87
  year: 2009
  ident: bib110
  article-title: Preliminary separation of the growth factors in platelet-rich plasma: effects on the proliferation of human marrow-derived mesenchymal stem cells
  publication-title: Chin Med J
– volume: 11
  start-page: 35
  year: 2015 Jan
  end-page: 44
  ident: bib96
  article-title: Emerging regulators of the inflammatory process in osteoarthritis
  publication-title: Nat Rev Rheumatol
– volume: 7
  year: 2016 Jan 21
  ident: bib23
  article-title: Mesenchymal stem cells and immunomodulation: current status and future prospects
  publication-title: Cell Death Dis
– volume: 1
  start-page: 139
  year: 2013 Jul 25
  end-page: 151
  ident: bib26
  article-title: Multipotent human mesenchymal stromal cells mediate expansion of myeloid-derived suppressor cells via hepatocyte growth factor/c-met and STAT3
  publication-title: Stem Cell Rep
– volume: 64
  start-page: 1466
  year: 2012
  end-page: 1476
  ident: bib97
  article-title: Active involvement of alarmins S100A8 and S100A9 in the regulation of synovial activation and joint destruction during mouse and human osteoarthritis
  publication-title: Arthritis Rheum
– volume: 11
  start-page: 21
  year: 2015
  end-page: 34
  ident: bib119
  article-title: Repair and tissue engineering technique for articular cartilage
  publication-title: Nat Rev Rheumatol
– volume: 39
  start-page: 45
  year: 2016 Feb-Mar
  end-page: 59
  ident: bib24
  article-title: The immunomodulatory potential of mesenchymal stromal cells: a story of a regulatory network
  publication-title: J Immunother
– year: 2010
  ident: bib46
  article-title: The structure and regenerative capacity of synovial joint tissues
  publication-title: Regenerative medicine and biomaterials for the repair of connective tissues
– volume: 14
  start-page: 346
  year: 2018
  end-page: 369
  ident: bib15
  article-title: Mesenchymal stem cells in the musculoskeletal system: from animal models to human tissue regeneration?
  publication-title: Stem Cell Rev
– volume: 5
  start-page: 273-287
  year: 2012
  ident: bib138
  article-title: Self-repair in degenerative joint disease
  publication-title: Curr Aging Sci
– volume: 5
  start-page: 77
  year: 2013 Apr
  end-page: 94
  ident: bib49
  article-title: Role of inflammation in the pathogenesis of osteoarthritis: latest findings and interpretations
  publication-title: Ther Adv Musculoskelet Dis
– volume: 30
  start-page: 845
  year: 2011
  end-page: 852
  ident: bib105
  article-title: Human platelet-rich plasma stimulates migration and chondrogenic differentiation of human subchondral progenitor cells
  publication-title: J Orthop Res
– volume: 20
  start-page: 573
  year: 2008
  end-page: 580
  ident: bib83
  article-title: Angiogenesis in osteoarthritis
  publication-title: Curr Opin Rheumatol
– volume: 23
  start-page: 170
  year: 2011
  end-page: 173
  ident: bib98
  article-title: Crystals, inflammation, and osteoarthritis
  publication-title: Curr Opin Rheumatol
– volume: 18
  start-page: 533-543
  year: 2009
  ident: bib121
  article-title: Novel culture system of mesenchymal stromal cells from human subcutaneous adipose tissue
  publication-title: Stem Cell Dev
– volume: 100
  start-page: 1249
  year: 2007 May 11
  end-page: 1260
  ident: bib127
  article-title: Adipose-derived stem cells for regenerative medicine
  publication-title: Circ Res
– volume: 14
  start-page: R7
  year: 2012
  ident: bib95
  article-title: Plasma proteins present in osteoarthritic synovial fluid can stimulate cytokine production via toll-like receptor 4
  publication-title: Arthritis Res Ther
– volume: 74
  start-page: 27
  year: 1993
  end-page: 34
  ident: bib11
  article-title: Uridine diphosphoglucose dehydrogenase activity in normal and rheumatoid synovium: the description of a specialized synovial lining cell
  publication-title: Int J Exp Pathol
– volume: 44
  start-page: 1928
  year: 2001
  end-page: 1942
  ident: bib13
  article-title: Multipotent mesenchymal stem cells from adult human synovial membrane
  publication-title: Arthritis Rheum
– volume: 420
  start-page: 868
  year: 2002
  end-page: 874
  ident: bib88
  article-title: Inflammation in atherosclerosis
  publication-title: Nature
– volume: 5
  start-page: 100
  year: 2011
  end-page: 106
  ident: bib8
  article-title: The normal synovium
  publication-title: Open Rheumatol J
– volume: 32
  start-page: 1349
  year: 2014
  end-page: 1355
  ident: bib113
  article-title: Autologous protein solution prepared from the blood of osteoarthritic patients contains an enhanced profile of anti-inflammatory cytokines and anabolic growth factors
  publication-title: J Orthop Res
– volume: 11
  start-page: 442
  year: 2015 Jun
  end-page: 452
  ident: bib27
  article-title: Bone marrow mesenchymal stromal cells induce proliferative, cytokinic and molecular changes during the T cell response: the importance of the IL-10/CD210 Axis
  publication-title: Stem Cell Rev Rep
– volume: 48
  start-page: 1215
  year: 2010 Jun
  end-page: 1224
  ident: bib34
  article-title: Derivation and characterization of human fetal MSCs: an alternative cell source for large-scale production of cardioprotective microparticles
  publication-title: J Mol Cell Cardiol
– volume: 64
  start-page: 1697
  year: 2012 Jun
  end-page: 1707
  ident: bib87
  article-title: Osteoarthritis: a disease of the joint as an organ
  publication-title: Arthritis Rheum
– volume: 11
  start-page: 7747
  year: 2019 Sep 24
  ident: bib116
  article-title: Use of intraarticular injections of platelet-rich plasma in the treatment of knee osteoarthritis: a review article
  publication-title: Orthop Rev
– volume: 203
  start-page: 398
  year: 2005 May
  end-page: 409
  ident: bib30
  article-title: FGF-2 enhances the mitotic and chondrogenic potentials of human adult bone marrow-derived mesenchymal stem cells
  publication-title: J Cell Physiol
– volume: 17
  start-page: 1674
  year: 2011
  end-page: 1679
  ident: bib99
  article-title: Identification of a central role for complement in osteoarthritis
  publication-title: Nat Med
– volume: 29
  start-page: 748
  year: 2013
  end-page: 755
  ident: bib125
  article-title: Mesenchymal stem cell injections improve symptoms of knee osteoarthritis
  publication-title: Arthroscopy
– volume: 40
  start-page: 82
  year: 2015 Apr
  end-page: 88
  ident: bib33
  article-title: Mesenchymal stem cell exosomes
  publication-title: Semin Cell Dev Biol
– volume: 6
  start-page: 5405
  year: 2014
  ident: bib102
  article-title: Does intra articular platelet rich plasma injection improve function, pain and quality of life in patients with osteoarthritis of the knee? A randomized clinical trial
  publication-title: Orthop Rev
– volume: 6
  start-page: 481
  year: 2011
  end-page: 492
  ident: bib134
  article-title: Mesenchymal stem cell exosome: a novel stem cell-based therapy for cardiovascular disease
  publication-title: Regen Med
– volume: 52
  start-page: 3492
  year: 2005
  end-page: 3501
  ident: bib78
  article-title: Macroscopic and microscopic features of synovial membrane inflammation in the osteoarthritic knee: correlating magnetic resonance imaging findings with disease severity
  publication-title: Arthritis Rheum
– year: 2019
  ident: bib117
  article-title: Stem cells for musculoskeletal diseases
  publication-title: Principle of regenerative medicine ch 54
– start-page: 7412304
  year: 2018
  ident: bib41
  article-title: Intervertebral disc-derived stem/progenitor cells as a promising cell source for intervertebral disc regeneration
  publication-title: Stem Cell Int
– volume: 149
  start-page: 1424
  year: 1992
  end-page: 1431
  ident: bib12
  article-title: Alpha 4/beta 1 integrin (VLA-4) ligands in arthritis. Vascular cell adhesion molecule-1 expression in synovium and on fibroblast-like synoviocytes
  publication-title: J Immunol
– year: 2019
  ident: bib28
  article-title: Mesenchymal stem cells in regenerative medicine
  publication-title: Principle of regenerative medicine ch 15
– volume: 44
  start-page: 7
  year: 2005
  end-page: 16
  ident: bib84
  article-title: Osteoarthritis, angiogenesis and inflammation
  publication-title: Rheumatology
– volume: 67
  start-page: 56
  year: 2017
  end-page: 64
  ident: bib135
  article-title: MSC exosome as a cell-free MSC therapy for cartilage regeneration: implications for osteoarthritis treatment
  publication-title: Semin Cell Dev Biol
– volume: 2
  start-page: 306
  year: 2013 Jul
  end-page: 316
  ident: bib44
  article-title: Mesenchymal stem cells in bone regeneration
  publication-title: Adv Wound Care
– volume: 48
  start-page: 3464
  year: 2003
  end-page: 3474
  ident: bib129
  article-title: Stem cell therapy in a caprine model of osteoarthritis
  publication-title: Arthritis Rheum
– volume: 131
  start-page: 324
  year: 2007 Oct 19
  end-page: 336
  ident: bib21
  article-title: Self-renewing osteoprogenitors in bone marrow sinusoids can organize a hematopoietic microenvironment
  publication-title: Cell
– volume: 10
  start-page: 10572
  year: 2020
  ident: bib114
  article-title: Characteristics of autologous protein solution and leucocyte-poor platelet-rich plasma for the treatment of osteoarthritis of the knee
  publication-title: Sci Rep
– volume: 24
  start-page: 1753
  year: 2016
  end-page: 1762
  ident: bib57
  article-title: Early osteoarthritis of the knee
  publication-title: Knee Surg Sports Traumatol Arthrosc
– start-page: 253
  year: 2016
  end-page: 273
  ident: bib45
  article-title: In situ tissue regeneration: host cell recruitment and biomaterial design
– volume: 32
  start-page: 414
  year: 2004
  end-page: 425
  ident: bib17
  article-title: Mesenchymal stem sells: paradoxes of passaging
  publication-title: Exp Hematol
– volume: 11
  start-page: 693-703
  year: 2016
  ident: bib130
  article-title: Adipose-derived stem cells in cartilage regeneration: current perspectives
  publication-title: Regen Med
– volume: 14
  start-page: 207
  year: 1962
  end-page: 220
  ident: bib9
  article-title: Electron microscopy of the human synovial membrane
  publication-title: J Cell Biol
– volume: 21
  start-page: 175
  year: 2013
  end-page: 185
  ident: bib106
  article-title: The effect of platelet-rich plasma on the regenerative therapy of muscle derived stem cells for articular cartilage repair
  publication-title: Osteoarthritis Cartilage
– volume: 12
  start-page: 1005
  year: 2006
  end-page: 1015
  ident: bib90
  article-title: Inflammation in Alzheimer disease: driving force, bystander or beneficial response?
  publication-title: Nat Med
– volume: 15
  start-page: B134
  year: 2007
  ident: bib109
  article-title: P181 Effects of autologous platelet-rich plasma on the metabolism of human articular chondrocytes
  publication-title: Osteoarthritis Cartilage
– volume: 20
  start-page: 401
  year: 2012
  end-page: 406
  ident: bib56
  article-title: Definition and classification of early osteoarthritis of the knee
  publication-title: Knee Surg Sports Traumatol Arthrosc
– volume: 54
  start-page: 465
  year: 2005
  end-page: 480
  ident: bib53
  article-title: Articular cartilage and osteoarthritis
  publication-title: Instr Course Lect
– volume: 25
  start-page: 958
  year: 2017
  end-page: 965
  ident: bib112
  article-title: Multiple PRP injections are more effective than single injections and hyaluronic acid in knees with early osteoarthritis: a randomized, double-blind, placebo-controlled trial
  publication-title: Knee Surg Sports Traumatol Arthrosc
– volume: 32
  start-page: 671
  year: 1993
  end-page: 675
  ident: bib74
  article-title: Mast cells in the synovium and synovial fluid in osteoarthritis
  publication-title: Br J Rheumatol
– volume: 225
  start-page: 757
  year: 2010
  end-page: 766
  ident: bib107
  article-title: Molecular basis of anti-inflammatory action of platelet-rich plasma on human chondrocytes: mechanisms of NF-κB inhibition via HGF
  publication-title: J Cell Physiol
– volume: 86
  start-page: 135
  year: 2008
  end-page: 144
  ident: bib22
  article-title: Pericytes: gatekeepers in tumour cell metastasis?
  publication-title: J Mol Med
– volume: 19
  start-page: 45
  year: 2017
  ident: bib85
  article-title: Innate immune responses and osteoarthritis
  publication-title: Curr Rheumatol Rep
– volume: 11
  start-page: 222
  year: 2019
  end-page: 235
  ident: bib131
  article-title: Application of mesenchymal stem cell therapy for the treatment of osteoarthritis of the knee: a concise review
  publication-title: World J Stem Cell
– volume: 10
  start-page: 260
  year: 2019
  ident: bib4
  article-title: Nomenclature clarification: synovial fibroblasts and synovial mesenchymal stem cells
  publication-title: Stem Cell Res Ther
– volume: 23
  start-page: 812
  year: 2015 May
  end-page: 823
  ident: bib35
  article-title: Mesenchymal stem cell-derived extracellular vesicles: toward cell-free therapeutic applications
  publication-title: Mol Ther
– volume: 63
  start-page: 2983
  year: 2011
  end-page: 2991
  ident: bib61
  article-title: Quantitative magnetic resonance imaging evidence of synovial proliferation is associated with radiographic severity of knee osteoarthritis
  publication-title: Arthritis Rheum
– volume: 2015
  start-page: 542502
  year: 2015
  ident: bib111
  article-title: PRP and articulat cartilage: a clinical update
  publication-title: BioMed Res Int
– volume: 26
  start-page: 192
  year: 2011
  end-page: 197
  ident: bib89
  article-title: Inflammation and age-related macular degeneration (AMD)
  publication-title: Semin Ophthalmol
– volume: 12
  start-page: 38
  year: 2004
  end-page: 45
  ident: bib79
  article-title: Characterization of cells from pannus-like tissue over articular cartilage of advanced osteoarthritis
  publication-title: Osteoarthritis Cartilage
– volume: 18
  start-page: 1441
  year: 2010
  end-page: 1447
  ident: bib52
  article-title: Circulating levels of IL-6 and TNF-alpha are associated with knee radiographic osteoarthritis and knee cartilage loss in older adults
  publication-title: Osteoarthtitis Cartilage
– volume: 26
  start-page: 342
  year: 2008
  end-page: 350
  ident: bib70
  article-title: Preponderance of sensory versus sympathetic nerve fibers and increased cellularity in the infrapatellar fat pad in anterior knee pain patients after primary arthroplasty
  publication-title: J Orthop Res
– reference: WHO Department of Chronic Diseases and Health Promotion.
– volume: 50
  start-page: 245
  year: 2011
  end-page: 247
  ident: bib47
  article-title: Developments in osteoarthritis
  publication-title: Rheumatology
– volume: 276
  start-page: 10229
  year: 2001
  end-page: 10233
  ident: bib94
  article-title: The extra domain A of fibronectin activates Toll-like receptor 4
  publication-title: J Biol Chem
– volume: 39
  start-page: 17
  year: 2014
  end-page: 24
  ident: bib7
  article-title: The biology of lubricin: near frictionless joint motion
  publication-title: Matrix Biol
– volume: 3
  start-page: 229
  year: 2008
  end-page: 230
  ident: bib20
  article-title: All MSCs are pericytes?
  publication-title: Cell Stem Cell
– volume: 17
  start-page: 613
  year: 2009
  end-page: 620
  ident: bib80
  article-title: Resistin is elevated following traumatic joint injury and causes matrix degradation and release of inflammatory cytokines from articular cartilage in vitro
  publication-title: Osteoarthritis Cartilage
– volume: 64
  start-page: 1263
  year: 2005
  end-page: 1267
  ident: bib76
  article-title: Synovial tissue inflammation in early and late osteoarthritis
  publication-title: Ann Rheum Dis
– volume: 4
  year: 2019
  ident: bib77
  article-title: Macrophage proliferation distinguishes 2 subgroups of knee osteoarthritis patients
  publication-title: JCI Insight
– volume: 48
  start-page: 2173
  year: 2003
  end-page: 2177
  ident: bib66
  article-title: Inflammation and angiogenesis in osteoarthritis
  publication-title: Arthritis Rheum
– volume: 25
  start-page: 2964-2971
  year: 2007
  ident: bib128
  article-title: Injectable mesenchymal stem cell therapy for large cartilage defects--a porcine model
  publication-title: Stem Cell
– start-page: 5e
  year: 2006
  ident: bib5
  article-title: Wheater's functional histology: a text and colour atlas
– volume: 6
  start-page: 206
  year: 2013 Jul
  end-page: 214
  ident: bib43
  article-title: Biological baseline of joint self-repair procedures
  publication-title: Curr Aging Sci
– start-page: 1
  year: 2010
  end-page: 12
  ident: bib51
  article-title: Osteoarthritis
  publication-title: ACP medicine section 15, chap. 10
– volume: 52
  start-page: 2521
  year: 2005
  end-page: 2529
  ident: bib14
  article-title: Comparison of human stem cells derived from various mesenchymal tissues: superiority of synovium as a cell source
  publication-title: Arthritis Rheum
– year: 2019
  ident: bib16
  article-title: Mesenchymal stem cells
  publication-title: Principle of regenerative medicine ch 14
– year: 2019
  ident: bib115
  article-title: Platelet-rich plasma in osteoarthritis treatment: review of current evidence
  publication-title: Ther Adv Chronic Dis
– volume: 7
  start-page: 180
  year: 2017
  end-page: 195
  ident: bib136
  article-title: Exosomes derived from miR-140-5p-overexpressing human synovial mesenchymal stem cells enhance cartilage tissue regeneration and prevent osteoarthritis of the knee in a rat model
  publication-title: Theranostics
– volume: 2016
  start-page: 9682757
  year: 2016
  ident: bib32
  article-title: How to improve the survival of transplanted mesenchymal stem cell in ischemic heart?
  publication-title: Stem Cell Int
– volume: 11
  start-page: 224
  year: 2009
  ident: bib50
  article-title: Cartilage homeostasis in health and rheumatic diseases
  publication-title: Arthritis Res Ther
– volume: 589
  start-page: 1257
  year: 2015 May 8
  end-page: 1265
  ident: bib36
  article-title: Mesenchymal-stem-cell-derived exosomes accelerate skeletal muscle regeneration
  publication-title: FEBS Lett
– volume: 5
  start-page: 4
  year: 2020
  ident: bib58
  article-title: Significance and definition of early knee osteoarthritis
  publication-title: Ann Joint
– volume: 5
  start-page: 8-10
  year: 2009
  ident: bib133
  article-title: Sleuthing the source of regeneration by MSCs
  publication-title: Cell Stem Cell
– volume: 49
  start-page: 657
  year: 2015
  end-page: 672
  ident: bib103
  article-title: Efficacy of platelet -rich plasma injections in osteoarthritis of the knee: a sistematic review and meta-analysis
  publication-title: Br J Sports Med
– volume: 9
  start-page: 10864
  year: 2019 Jul 26
  ident: bib38
  article-title: Infrapatellar fat-pad derived MSC response to inflammation and fibrosis induces an immunomodulatory phenotype involving CD10-mediated Substance P degradation
  publication-title: Sci Rep
– volume: 101
  start-page: 967-973
  year: 2017
  ident: bib72
  article-title: Substance P-mediated chemokine production promotes monocyte migration
  publication-title: J Leukoc Biol
– volume: 54
  start-page: 1222
  year: 2006 Apr
  end-page: 1232
  ident: bib31
  article-title: Potent induction of chondrocytic differentiation of human adipose-derived adult stem cells by bone morphogenetic protein 6
  publication-title: Arthritis Rheum
– volume: 179
  start-page: 10
  year: 2009
  end-page: 24
  ident: bib59
  article-title: The contribution of the synovium, synovial derived inflammatory cytokines and neuropeptides to the pathogenesis of osteoarthritis
  publication-title: Vet J
– volume: 13
  start-page: 361
  year: 2005
  end-page: 367
  ident: bib64
  article-title: Synovitis: a potential predictive factor of structural progression of medial tibiofemoral knee osteoarthritis – results of a 1 year longitudinal arthroscopic study in 422 patients
  publication-title: Osteoarthritis Cartilage
– start-page: 4019873
  year: 2016
  end-page: 4019910
  ident: bib39
  article-title: Infrapatellar fat pad: an alternative source of adipose-derived mesenchymal stem cells
  publication-title: Arthritis
– volume: 54
  start-page: 1954-1963
  year: 2015
  ident: bib92
  article-title: Unravelling osteoarthritis-related synovial fibrosis: a step closer to solving joint stiffness
  publication-title: Rheumatology
– reference: .
– volume: 11
  start-page: 25
  year: 2016
  ident: bib71
  article-title: Predominance of synovial sensory nerve fibers in arthrofibrosis following total knee arthroplasty compared to osteoarthritis of the knee
  publication-title: J Orthop Surg Res
– volume: 7
  start-page: 29
  year: 2009
  ident: bib122
  article-title: Non-expanded adipose stromal vascular fraction cell therapy for multiple sclerosis
  publication-title: J Transl Med
– volume: 63
  start-page: 391
  year: 2011
  end-page: 400
  ident: bib65
  article-title: Synovial inflammation in patients undergoing arthroscopic meniscectomy: molecular characterization and relationship to symptoms
  publication-title: Arthritis Rheum
– volume: 1
  year: 2015
  ident: bib69
  article-title: Early knee osteoarthritis
  publication-title: RMD Open
– volume: 15
  start-page: 431
  year: 2009
  end-page: 435
  ident: bib104
  article-title: Buffered platelet-rich plasma enhances mesenchymal stem cell proliferation and chondrogenic differentiation
  publication-title: Tissue Eng C Methods
– volume: 70
  start-page: 1804
  year: 2011
  end-page: 1809
  ident: bib62
  article-title: Presence of MRI-detected joint effusion and synovitis increases the risk of cartilage loss in knees without osteoarthritis at 30-month follow-up: the MOST study
  publication-title: Ann Rheum Dis
– volume: 93
  start-page: 1
  year: 2009
  end-page: 24
  ident: bib75
  article-title: Etiopathogenesis of osteoarthritis
  publication-title: Med Clin
– volume: 9
  start-page: 337
  year: 2004
  end-page: 344
  ident: bib108
  article-title: Effects of platelet growth factors on human mesenchymal stem cells and human endothelial cells in vitro
  publication-title: Eur J Med Res
– volume: 20
  start-page: 565
  year: 2008
  end-page: 572
  ident: bib91
  article-title: Innate immune system activation in osteoarthritis: is osteoarthritis a chronic wound?
  publication-title: Curr Opin Rheumatol
– volume: 30
  start-page: 160
  year: 2018
  ident: bib60
  article-title: Epidemiology of osteoarthritis: literature update
  publication-title: Curr Opin Rheumatol
– volume: 469
  start-page: 2696
  year: 2011
  end-page: 2705
  ident: bib118
  article-title: Clinical cartilage restoration: evolution and overview
  publication-title: Clin Orthop Relat Res
– volume: 64
  start-page: 1697
  issue: 6
  year: 2012
  ident: 10.1016/j.reth.2020.07.007_bib87
  article-title: Osteoarthritis: a disease of the joint as an organ
  publication-title: Arthritis Rheum
  doi: 10.1002/art.34453
– volume: 34
  start-page: 1092
  issue: 12
  year: 2018
  ident: 10.1016/j.reth.2020.07.007_bib132
  article-title: Cellules souches mésenchymateuses et médecine régénératrice - quel avenir pour l’arthrose ? [Mesenchymal stem cells and regenerative medicine: future perspectives in osteoarthritis]
  publication-title: Med Sci
– volume: 50
  start-page: 245
  year: 2011
  ident: 10.1016/j.reth.2020.07.007_bib47
  article-title: Developments in osteoarthritis
  publication-title: Rheumatology
  doi: 10.1093/rheumatology/keq373
– volume: 11
  start-page: 35
  issue: 1
  year: 2015
  ident: 10.1016/j.reth.2020.07.007_bib96
  article-title: Emerging regulators of the inflammatory process in osteoarthritis
  publication-title: Nat Rev Rheumatol
  doi: 10.1038/nrrheum.2014.162
– volume: 14
  start-page: 346
  year: 2018
  ident: 10.1016/j.reth.2020.07.007_bib15
  article-title: Mesenchymal stem cells in the musculoskeletal system: from animal models to human tissue regeneration?
  publication-title: Stem Cell Rev
  doi: 10.1007/s12015-018-9800-6
– volume: 63
  start-page: 391
  year: 2011
  ident: 10.1016/j.reth.2020.07.007_bib65
  article-title: Synovial inflammation in patients undergoing arthroscopic meniscectomy: molecular characterization and relationship to symptoms
  publication-title: Arthritis Rheum
  doi: 10.1002/art.30137
– volume: 10
  start-page: 10572
  year: 2020
  ident: 10.1016/j.reth.2020.07.007_bib114
  article-title: Characteristics of autologous protein solution and leucocyte-poor platelet-rich plasma for the treatment of osteoarthritis of the knee
  publication-title: Sci Rep
  doi: 10.1038/s41598-020-67099-y
– volume: 1
  year: 2015
  ident: 10.1016/j.reth.2020.07.007_bib69
  article-title: Early knee osteoarthritis
  publication-title: RMD Open
  doi: 10.1136/rmdopen-2015-000062
– volume: 5
  start-page: 273-287
  issue: 3
  year: 2012
  ident: 10.1016/j.reth.2020.07.007_bib138
  article-title: Self-repair in degenerative joint disease
  publication-title: Curr Aging Sci
– volume: 6
  start-page: 625
  year: 2010
  ident: 10.1016/j.reth.2020.07.007_bib67
  article-title: The role of synovitis in pathophysiology and clinical symptoms of osteoarthritis
  publication-title: Nat Rev Rheumatol
  doi: 10.1038/nrrheum.2010.159
– volume: 14
  start-page: R7
  year: 2012
  ident: 10.1016/j.reth.2020.07.007_bib95
  article-title: Plasma proteins present in osteoarthritic synovial fluid can stimulate cytokine production via toll-like receptor 4
  publication-title: Arthritis Res Ther
  doi: 10.1186/ar3555
– volume: 17
  start-page: 939
  issue: 6
  year: 2009
  ident: 10.1016/j.reth.2020.07.007_bib18
  article-title: Repair of tissues by adult/stem progenitor cells (MSCs): controversies, myths, and changing paradigsms
  publication-title: Mol Ther
  doi: 10.1038/mt.2009.62
– volume: 38
  start-page: 129
  year: 2011
  ident: 10.1016/j.reth.2020.07.007_bib81
  article-title: Thrombin-cleaved osteopontin levels in synovial fluid correlate with disease severity of knee osteoarthritis
  publication-title: J Rheumatol
  doi: 10.3899/jrheum.100637
– start-page: 5e
  year: 2006
  ident: 10.1016/j.reth.2020.07.007_bib5
– volume: 54
  start-page: 465
  year: 2005
  ident: 10.1016/j.reth.2020.07.007_bib53
  article-title: Articular cartilage and osteoarthritis
  publication-title: Instr Course Lect
– volume: 18
  start-page: 533-543
  issue: 4
  year: 2009
  ident: 10.1016/j.reth.2020.07.007_bib121
  article-title: Novel culture system of mesenchymal stromal cells from human subcutaneous adipose tissue
  publication-title: Stem Cell Dev
  doi: 10.1089/scd.2008.0358
– volume: 7
  year: 2016
  ident: 10.1016/j.reth.2020.07.007_bib23
  article-title: Mesenchymal stem cells and immunomodulation: current status and future prospects
  publication-title: Cell Death Dis
  doi: 10.1038/cddis.2015.327
– volume: 21
  start-page: 2
  year: 2010
  ident: 10.1016/j.reth.2020.07.007_bib48
  article-title: Is osteoarthritis a disease involving only cartilage or other articular tissues?
  publication-title: Eklem Hastalik Cerrahisi
– volume: 17
  start-page: 1674
  year: 2011
  ident: 10.1016/j.reth.2020.07.007_bib99
  article-title: Identification of a central role for complement in osteoarthritis
  publication-title: Nat Med
  doi: 10.1038/nm.2543
– volume: 6
  start-page: 481
  year: 2011
  ident: 10.1016/j.reth.2020.07.007_bib134
  article-title: Mesenchymal stem cell exosome: a novel stem cell-based therapy for cardiovascular disease
  publication-title: Regen Med
  doi: 10.2217/rme.11.35
– volume: 52
  start-page: 3492
  year: 2005
  ident: 10.1016/j.reth.2020.07.007_bib78
  article-title: Macroscopic and microscopic features of synovial membrane inflammation in the osteoarthritic knee: correlating magnetic resonance imaging findings with disease severity
  publication-title: Arthritis Rheum
  doi: 10.1002/art.21373
– volume: 21
  start-page: 1627
  issue: 11
  year: 2013
  ident: 10.1016/j.reth.2020.07.007_bib101
  article-title: Basic science and clinical application of platelet -rich plasma for cartilage defects and osteoarthritis: a review
  publication-title: Osteoarthritis Cartilage
  doi: 10.1016/j.joca.2013.07.017
– volume: 420
  start-page: 868
  year: 2002
  ident: 10.1016/j.reth.2020.07.007_bib88
  article-title: Inflammation in atherosclerosis
  publication-title: Nature
  doi: 10.1038/nature01323
– volume: 2016
  start-page: 9682757
  year: 2016
  ident: 10.1016/j.reth.2020.07.007_bib32
  article-title: How to improve the survival of transplanted mesenchymal stem cell in ischemic heart?
  publication-title: Stem Cell Int
  doi: 10.1155/2016/9682757
– volume: 5
  start-page: 4
  year: 2020
  ident: 10.1016/j.reth.2020.07.007_bib58
  article-title: Significance and definition of early knee osteoarthritis
  publication-title: Ann Joint
  doi: 10.21037/aoj.2019.09.02
– volume: 73
  start-page: 4249
  issue: 22
  year: 2016
  ident: 10.1016/j.reth.2020.07.007_bib40
  article-title: Neuropeptide substance P and the immune response
  publication-title: Cell Mol Life Sci
  doi: 10.1007/s00018-016-2293-z
– volume: 26
  start-page: 192
  year: 2011
  ident: 10.1016/j.reth.2020.07.007_bib89
  article-title: Inflammation and age-related macular degeneration (AMD)
  publication-title: Semin Ophthalmol
  doi: 10.3109/08820538.2011.570849
– volume: 15
  start-page: B134
  year: 2007
  ident: 10.1016/j.reth.2020.07.007_bib109
  article-title: P181 Effects of autologous platelet-rich plasma on the metabolism of human articular chondrocytes
  publication-title: Osteoarthritis Cartilage
  doi: 10.1016/S1063-4584(07)61536-2
– volume: 63
  start-page: 2983
  year: 2011
  ident: 10.1016/j.reth.2020.07.007_bib61
  article-title: Quantitative magnetic resonance imaging evidence of synovial proliferation is associated with radiographic severity of knee osteoarthritis
  publication-title: Arthritis Rheum
  doi: 10.1002/art.30471
– volume: 22
  start-page: 1
  year: 2020
  ident: 10.1016/j.reth.2020.07.007_bib139
  article-title: The importance of ultrasound in identifying and differentiating patients with early inflammatory arthritis: a narrative review
  publication-title: Arthritis Res Ther
  doi: 10.1186/s13075-019-2050-4
– volume: 1
  start-page: 139
  issue: 2
  year: 2013
  ident: 10.1016/j.reth.2020.07.007_bib26
  article-title: Multipotent human mesenchymal stromal cells mediate expansion of myeloid-derived suppressor cells via hepatocyte growth factor/c-met and STAT3
  publication-title: Stem Cell Rep
  doi: 10.1016/j.stemcr.2013.06.006
– volume: 5
  start-page: 8-10
  issue: 1
  year: 2009
  ident: 10.1016/j.reth.2020.07.007_bib133
  article-title: Sleuthing the source of regeneration by MSCs
  publication-title: Cell Stem Cell
  doi: 10.1016/j.stem.2009.06.013
– volume: 20
  start-page: 573
  year: 2008
  ident: 10.1016/j.reth.2020.07.007_bib83
  article-title: Angiogenesis in osteoarthritis
  publication-title: Curr Opin Rheumatol
  doi: 10.1097/BOR.0b013e3283103d12
– volume: 305
  start-page: 33
  issue: 1
  year: 2005
  ident: 10.1016/j.reth.2020.07.007_bib25
  article-title: Mesenchymal stem cells inhibit lymphocyte proliferation by mitogens and alloantigens by different mechanisms
  publication-title: Exp Cell Res
  doi: 10.1016/j.yexcr.2004.12.013
– volume: 12
  start-page: 1005
  year: 2006
  ident: 10.1016/j.reth.2020.07.007_bib90
  article-title: Inflammation in Alzheimer disease: driving force, bystander or beneficial response?
  publication-title: Nat Med
– volume: 39
  start-page: 17
  year: 2014
  ident: 10.1016/j.reth.2020.07.007_bib7
  article-title: The biology of lubricin: near frictionless joint motion
  publication-title: Matrix Biol
  doi: 10.1016/j.matbio.2014.08.008
– volume: 98
  start-page: 1076
  year: 2006
  ident: 10.1016/j.reth.2020.07.007_bib29
  article-title: Mesenchymal stem cells as trophic mediators
  publication-title: J Cell Biochem
  doi: 10.1002/jcb.20886
– volume: 100
  start-page: 1249
  issue: 9
  year: 2007
  ident: 10.1016/j.reth.2020.07.007_bib127
  article-title: Adipose-derived stem cells for regenerative medicine
  publication-title: Circ Res
  doi: 10.1161/01.RES.0000265074.83288.09
– volume: 101
  start-page: 967-973
  issue: 4
  year: 2017
  ident: 10.1016/j.reth.2020.07.007_bib72
  article-title: Substance P-mediated chemokine production promotes monocyte migration
  publication-title: J Leukoc Biol
  doi: 10.1189/jlb.1AB0416-188RR
– volume: 11
  start-page: 21
  issue: 1
  year: 2015
  ident: 10.1016/j.reth.2020.07.007_bib119
  article-title: Repair and tissue engineering technique for articular cartilage
  publication-title: Nat Rev Rheumatol
  doi: 10.1038/nrrheum.2014.157
– volume: 23
  start-page: 812
  issue: 5
  year: 2015
  ident: 10.1016/j.reth.2020.07.007_bib35
  article-title: Mesenchymal stem cell-derived extracellular vesicles: toward cell-free therapeutic applications
  publication-title: Mol Ther
  doi: 10.1038/mt.2015.44
– start-page: 1741
  year: 2011
  ident: 10.1016/j.reth.2020.07.007_bib54
  article-title: Pathogenesis and pathology of osteoarthritis
– volume: 9
  start-page: 337
  year: 2004
  ident: 10.1016/j.reth.2020.07.007_bib108
  article-title: Effects of platelet growth factors on human mesenchymal stem cells and human endothelial cells in vitro
  publication-title: Eur J Med Res
– year: 2013
  ident: 10.1016/j.reth.2020.07.007_bib3
– volume: 24
  start-page: 2135
  issue: 12
  year: 2016
  ident: 10.1016/j.reth.2020.07.007_bib37
  article-title: Exosomes derived from human embryonic mesenchymal stem cells promote osteochondral regeneration
  publication-title: Osteoarthritis Cartilage
  doi: 10.1016/j.joca.2016.06.022
– volume: 225
  start-page: 757
  year: 2010
  ident: 10.1016/j.reth.2020.07.007_bib107
  article-title: Molecular basis of anti-inflammatory action of platelet-rich plasma on human chondrocytes: mechanisms of NF-κB inhibition via HGF
  publication-title: J Cell Physiol
  doi: 10.1002/jcp.22274
– volume: 74
  start-page: 27
  year: 1993
  ident: 10.1016/j.reth.2020.07.007_bib11
  article-title: Uridine diphosphoglucose dehydrogenase activity in normal and rheumatoid synovium: the description of a specialized synovial lining cell
  publication-title: Int J Exp Pathol
– volume: 32
  start-page: 671
  year: 1993
  ident: 10.1016/j.reth.2020.07.007_bib74
  article-title: Mast cells in the synovium and synovial fluid in osteoarthritis
  publication-title: Br J Rheumatol
  doi: 10.1093/rheumatology/32.8.671
– volume: 40
  start-page: 82
  year: 2015
  ident: 10.1016/j.reth.2020.07.007_bib33
  article-title: Mesenchymal stem cell exosomes
  publication-title: Semin Cell Dev Biol
  doi: 10.1016/j.semcdb.2015.03.001
– volume: 14
  start-page: 207
  year: 1962
  ident: 10.1016/j.reth.2020.07.007_bib9
  article-title: Electron microscopy of the human synovial membrane
  publication-title: J Cell Biol
  doi: 10.1083/jcb.14.2.207
– volume: 1192
  start-page: 230
  year: 2010
  ident: 10.1016/j.reth.2020.07.007_bib55
  article-title: Articular cartilage and subchondral bone in the pathogenesis of osteoarthritis
  publication-title: Ann NY Acad Sci
  doi: 10.1111/j.1749-6632.2009.05240.x
– volume: 1
  start-page: 1006
  issue: 2
  year: 2016
  ident: 10.1016/j.reth.2020.07.007_bib63
  article-title: MRI in degenerative joint disease (DJD): a proposal for imaging standardization in regenerative medicine
  publication-title: SM Musculoskelet Disord
– volume: 52
  start-page: 2521
  year: 2005
  ident: 10.1016/j.reth.2020.07.007_bib14
  article-title: Comparison of human stem cells derived from various mesenchymal tissues: superiority of synovium as a cell source
  publication-title: Arthritis Rheum
  doi: 10.1002/art.21212
– volume: 203
  start-page: 398
  issue: 2
  year: 2005
  ident: 10.1016/j.reth.2020.07.007_bib30
  article-title: FGF-2 enhances the mitotic and chondrogenic potentials of human adult bone marrow-derived mesenchymal stem cells
  publication-title: J Cell Physiol
  doi: 10.1002/jcp.20238
– volume: 11
  start-page: 222
  issue: 4
  year: 2019
  ident: 10.1016/j.reth.2020.07.007_bib131
  article-title: Application of mesenchymal stem cell therapy for the treatment of osteoarthritis of the knee: a concise review
  publication-title: World J Stem Cell
  doi: 10.4252/wjsc.v11.i4.222
– volume: 18
  start-page: 1441
  year: 2010
  ident: 10.1016/j.reth.2020.07.007_bib52
  article-title: Circulating levels of IL-6 and TNF-alpha are associated with knee radiographic osteoarthritis and knee cartilage loss in older adults
  publication-title: Osteoarthtitis Cartilage
  doi: 10.1016/j.joca.2010.08.016
– volume: 13
  start-page: 361
  year: 2005
  ident: 10.1016/j.reth.2020.07.007_bib64
  article-title: Synovitis: a potential predictive factor of structural progression of medial tibiofemoral knee osteoarthritis – results of a 1 year longitudinal arthroscopic study in 422 patients
  publication-title: Osteoarthritis Cartilage
  doi: 10.1016/j.joca.2005.01.005
– volume: 2
  start-page: 306
  issue: 6
  year: 2013
  ident: 10.1016/j.reth.2020.07.007_bib44
  article-title: Mesenchymal stem cells in bone regeneration
  publication-title: Adv Wound Care
  doi: 10.1089/wound.2012.0420
– volume: 21
  start-page: 175
  year: 2013
  ident: 10.1016/j.reth.2020.07.007_bib106
  article-title: The effect of platelet-rich plasma on the regenerative therapy of muscle derived stem cells for articular cartilage repair
  publication-title: Osteoarthritis Cartilage
  doi: 10.1016/j.joca.2012.09.018
– volume: 35
  start-page: 1179
  year: 1992
  ident: 10.1016/j.reth.2020.07.007_bib10
  article-title: Light microscopic characterization of the fibroblast-like synovial intimal cell (synoviocyte)
  publication-title: Arthritis Rheum
  doi: 10.1002/art.1780351010
– volume: 9
  start-page: 10864
  issue: 1
  year: 2019
  ident: 10.1016/j.reth.2020.07.007_bib38
  article-title: Infrapatellar fat-pad derived MSC response to inflammation and fibrosis induces an immunomodulatory phenotype involving CD10-mediated Substance P degradation
  publication-title: Sci Rep
  doi: 10.1038/s41598-019-47391-2
– start-page: 1
  year: 2010
  ident: 10.1016/j.reth.2020.07.007_bib51
  article-title: Osteoarthritis
– volume: 78
  start-page: 955
  year: 2019
  ident: 10.1016/j.reth.2020.07.007_bib42
  article-title: FRI0520 The human enthesis contains populations of Mesenchymal stem cells with distinct functional characteristics
  publication-title: Ann Rheum Dis
– volume: 39
  start-page: 45
  issue: 2
  year: 2016
  ident: 10.1016/j.reth.2020.07.007_bib24
  article-title: The immunomodulatory potential of mesenchymal stromal cells: a story of a regulatory network
  publication-title: J Immunother
– volume: 2015
  start-page: 542502
  year: 2015
  ident: 10.1016/j.reth.2020.07.007_bib111
  article-title: PRP and articulat cartilage: a clinical update
  publication-title: BioMed Res Int
  doi: 10.1155/2015/542502
– volume: 122
  start-page: 83-87
  issue: 1
  year: 2009
  ident: 10.1016/j.reth.2020.07.007_bib110
  article-title: Preliminary separation of the growth factors in platelet-rich plasma: effects on the proliferation of human marrow-derived mesenchymal stem cells
  publication-title: Chin Med J
– volume: 48
  start-page: 3464
  issue: 12
  year: 2003
  ident: 10.1016/j.reth.2020.07.007_bib129
  article-title: Stem cell therapy in a caprine model of osteoarthritis
  publication-title: Arthritis Rheum
  doi: 10.1002/art.11365
– volume: 12
  start-page: 38
  year: 2004
  ident: 10.1016/j.reth.2020.07.007_bib79
  article-title: Characterization of cells from pannus-like tissue over articular cartilage of advanced osteoarthritis
  publication-title: Osteoarthritis Cartilage
  doi: 10.1016/j.joca.2003.08.004
– volume: 48
  start-page: 1215
  issue: 6
  year: 2010
  ident: 10.1016/j.reth.2020.07.007_bib34
  article-title: Derivation and characterization of human fetal MSCs: an alternative cell source for large-scale production of cardioprotective microparticles
  publication-title: J Mol Cell Cardiol
  doi: 10.1016/j.yjmcc.2009.12.021
– volume: 589
  start-page: 1257
  issue: 11
  year: 2015
  ident: 10.1016/j.reth.2020.07.007_bib36
  article-title: Mesenchymal-stem-cell-derived exosomes accelerate skeletal muscle regeneration
  publication-title: FEBS Lett
  doi: 10.1016/j.febslet.2015.03.031
– volume: 20
  start-page: 565
  year: 2008
  ident: 10.1016/j.reth.2020.07.007_bib91
  article-title: Innate immune system activation in osteoarthritis: is osteoarthritis a chronic wound?
  publication-title: Curr Opin Rheumatol
  doi: 10.1097/BOR.0b013e32830aba34
– volume: 86
  start-page: 135
  year: 2008
  ident: 10.1016/j.reth.2020.07.007_bib22
  article-title: Pericytes: gatekeepers in tumour cell metastasis?
  publication-title: J Mol Med
  doi: 10.1007/s00109-007-0258-2
– volume: 276
  start-page: 10229
  year: 2001
  ident: 10.1016/j.reth.2020.07.007_bib94
  article-title: The extra domain A of fibronectin activates Toll-like receptor 4
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M100099200
– volume: 179
  start-page: 10
  year: 2009
  ident: 10.1016/j.reth.2020.07.007_bib59
  article-title: The contribution of the synovium, synovial derived inflammatory cytokines and neuropeptides to the pathogenesis of osteoarthritis
  publication-title: Vet J
  doi: 10.1016/j.tvjl.2007.08.013
– volume: 44
  start-page: 1928
  year: 2001
  ident: 10.1016/j.reth.2020.07.007_bib13
  article-title: Multipotent mesenchymal stem cells from adult human synovial membrane
  publication-title: Arthritis Rheum
  doi: 10.1002/1529-0131(200108)44:8<1928::AID-ART331>3.0.CO;2-P
– volume: 20
  start-page: 401
  issue: 3
  year: 2012
  ident: 10.1016/j.reth.2020.07.007_bib56
  article-title: Definition and classification of early osteoarthritis of the knee
  publication-title: Knee Surg Sports Traumatol Arthrosc
  doi: 10.1007/s00167-011-1743-2
– volume: 4
  issue: 2
  year: 2019
  ident: 10.1016/j.reth.2020.07.007_bib77
  article-title: Macrophage proliferation distinguishes 2 subgroups of knee osteoarthritis patients
  publication-title: JCI Insight
  doi: 10.1172/jci.insight.125325
– volume: 10
  start-page: 260
  year: 2019
  ident: 10.1016/j.reth.2020.07.007_bib4
  article-title: Nomenclature clarification: synovial fibroblasts and synovial mesenchymal stem cells
  publication-title: Stem Cell Res Ther
  doi: 10.1186/s13287-019-1359-x
– volume: 64
  start-page: 1466
  year: 2012
  ident: 10.1016/j.reth.2020.07.007_bib97
  article-title: Active involvement of alarmins S100A8 and S100A9 in the regulation of synovial activation and joint destruction during mouse and human osteoarthritis
  publication-title: Arthritis Rheum
  doi: 10.1002/art.34315
– volume: 11
  start-page: 25
  year: 2016
  ident: 10.1016/j.reth.2020.07.007_bib71
  article-title: Predominance of synovial sensory nerve fibers in arthrofibrosis following total knee arthroplasty compared to osteoarthritis of the knee
  publication-title: J Orthop Surg Res
  doi: 10.1186/s13018-016-0359-0
– year: 2019
  ident: 10.1016/j.reth.2020.07.007_bib6
– volume: 54
  start-page: 1954-1963
  issue: 11
  year: 2015
  ident: 10.1016/j.reth.2020.07.007_bib92
  article-title: Unravelling osteoarthritis-related synovial fibrosis: a step closer to solving joint stiffness
  publication-title: Rheumatology
  doi: 10.1093/rheumatology/kev228
– volume: 11
  start-page: 442
  issue: 3
  year: 2015
  ident: 10.1016/j.reth.2020.07.007_bib27
  article-title: Bone marrow mesenchymal stromal cells induce proliferative, cytokinic and molecular changes during the T cell response: the importance of the IL-10/CD210 Axis
  publication-title: Stem Cell Rev Rep
  doi: 10.1007/s12015-014-9567-3
– year: 2010
  ident: 10.1016/j.reth.2020.07.007_bib46
  article-title: The structure and regenerative capacity of synovial joint tissues
– volume: 15
  start-page: 431
  year: 2009
  ident: 10.1016/j.reth.2020.07.007_bib104
  article-title: Buffered platelet-rich plasma enhances mesenchymal stem cell proliferation and chondrogenic differentiation
  publication-title: Tissue Eng C Methods
  doi: 10.1089/ten.tec.2008.0534
– volume: 93
  start-page: 1
  year: 2009
  ident: 10.1016/j.reth.2020.07.007_bib75
  article-title: Etiopathogenesis of osteoarthritis
  publication-title: Med Clin
– volume: 17
  start-page: 230
  year: 2016
  ident: 10.1016/j.reth.2020.07.007_bib124
  article-title: Mesenchymal stem cell therapy in the treatment of osteoarthritis: reparative pathways, safety and efficacy - a review
  publication-title: BMC Muscoskel Disord
  doi: 10.1186/s12891-016-1085-9
– start-page: 253
  year: 2016
  ident: 10.1016/j.reth.2020.07.007_bib45
– volume: 7
  start-page: 29
  year: 2009
  ident: 10.1016/j.reth.2020.07.007_bib122
  article-title: Non-expanded adipose stromal vascular fraction cell therapy for multiple sclerosis
  publication-title: J Transl Med
  doi: 10.1186/1479-5876-7-29
– volume: 29
  start-page: 748
  year: 2013
  ident: 10.1016/j.reth.2020.07.007_bib125
  article-title: Mesenchymal stem cell injections improve symptoms of knee osteoarthritis
  publication-title: Arthroscopy
  doi: 10.1016/j.arthro.2012.11.017
– volume: 11
  start-page: 224
  year: 2009
  ident: 10.1016/j.reth.2020.07.007_bib50
  article-title: Cartilage homeostasis in health and rheumatic diseases
  publication-title: Arthritis Res Ther
  doi: 10.1186/ar2592
– year: 2004
  ident: 10.1016/j.reth.2020.07.007_bib2
– volume: 9
  start-page: 11
  issue: 1
  year: 2011
  ident: 10.1016/j.reth.2020.07.007_bib19
  article-title: The MSCs: an injury drugstore
  publication-title: Cell Stem Cell
  doi: 10.1016/j.stem.2011.06.008
– volume: 49
  start-page: 657
  issue: 10
  year: 2015
  ident: 10.1016/j.reth.2020.07.007_bib103
  article-title: Efficacy of platelet -rich plasma injections in osteoarthritis of the knee: a sistematic review and meta-analysis
  publication-title: Br J Sports Med
  doi: 10.1136/bjsports-2014-094036
– volume: 70
  start-page: 1804
  year: 2011
  ident: 10.1016/j.reth.2020.07.007_bib62
  article-title: Presence of MRI-detected joint effusion and synovitis increases the risk of cartilage loss in knees without osteoarthritis at 30-month follow-up: the MOST study
  publication-title: Ann Rheum Dis
  doi: 10.1136/ard.2011.150243
– volume: 64
  start-page: 1263
  year: 2005
  ident: 10.1016/j.reth.2020.07.007_bib76
  article-title: Synovial tissue inflammation in early and late osteoarthritis
  publication-title: Ann Rheum Dis
  doi: 10.1136/ard.2004.025270
– volume: 11
  start-page: 182-191
  year: 2019
  ident: 10.1016/j.reth.2020.07.007_bib120
  article-title: Omentum a powerful biological source in regenerative surgery
  publication-title: Regen Ther
– volume: 17
  start-page: 613
  year: 2009
  ident: 10.1016/j.reth.2020.07.007_bib80
  article-title: Resistin is elevated following traumatic joint injury and causes matrix degradation and release of inflammatory cytokines from articular cartilage in vitro
  publication-title: Osteoarthritis Cartilage
  doi: 10.1016/j.joca.2008.08.007
– volume: 35
  start-page: 53-60
  issue: 1
  year: 2017
  ident: 10.1016/j.reth.2020.07.007_bib86
  article-title: The infrapatellar fat pad induces inflammatory and degradative effects in articular cells but not through leptin or adiponectin
  publication-title: Clin Exp Rheumatol
– volume: 32
  start-page: 414
  issue: 5
  year: 2004
  ident: 10.1016/j.reth.2020.07.007_bib17
  article-title: Mesenchymal stem sells: paradoxes of passaging
  publication-title: Exp Hematol
  doi: 10.1016/j.exphem.2004.02.004
– volume: 14
  start-page: 13
  issue: 1
  year: 2006
  ident: 10.1016/j.reth.2020.07.007_bib68
  article-title: Osteoarthritis cartilage histopathology: grading and staging
  publication-title: Osteoarthritis Cartilage
  doi: 10.1016/j.joca.2005.07.014
– volume: 7
  start-page: 180
  year: 2017
  ident: 10.1016/j.reth.2020.07.007_bib136
  article-title: Exosomes derived from miR-140-5p-overexpressing human synovial mesenchymal stem cells enhance cartilage tissue regeneration and prevent osteoarthritis of the knee in a rat model
  publication-title: Theranostics
  doi: 10.7150/thno.17133
– volume: 62
  start-page: 647
  year: 2010
  ident: 10.1016/j.reth.2020.07.007_bib73
  article-title: The role of synovial macrophages and macrophage-produced mediators in driving inflammatory and destructive responses in osteoarthritis
  publication-title: Arthritis Rheum
  doi: 10.1002/art.27290
– volume: 26
  start-page: 342
  year: 2008
  ident: 10.1016/j.reth.2020.07.007_bib70
  article-title: Preponderance of sensory versus sympathetic nerve fibers and increased cellularity in the infrapatellar fat pad in anterior knee pain patients after primary arthroplasty
  publication-title: J Orthop Res
  doi: 10.1002/jor.20498
– volume: 23
  start-page: 170
  year: 2011
  ident: 10.1016/j.reth.2020.07.007_bib98
  article-title: Crystals, inflammation, and osteoarthritis
  publication-title: Curr Opin Rheumatol
  doi: 10.1097/BOR.0b013e3283432d1f
– volume: 25
  start-page: 2964-2971
  issue: 11
  year: 2007
  ident: 10.1016/j.reth.2020.07.007_bib128
  article-title: Injectable mesenchymal stem cell therapy for large cartilage defects--a porcine model
  publication-title: Stem Cell
  doi: 10.1634/stemcells.2006-0311
– ident: 10.1016/j.reth.2020.07.007_bib1
– year: 2019
  ident: 10.1016/j.reth.2020.07.007_bib16
  article-title: Mesenchymal stem cells
– start-page: 4019873
  year: 2016
  ident: 10.1016/j.reth.2020.07.007_bib39
  article-title: Infrapatellar fat pad: an alternative source of adipose-derived mesenchymal stem cells
  publication-title: Arthritis
– volume: 24
  start-page: 1753
  year: 2016
  ident: 10.1016/j.reth.2020.07.007_bib57
  article-title: Early osteoarthritis of the knee
  publication-title: Knee Surg Sports Traumatol Arthrosc
  doi: 10.1007/s00167-016-4068-3
– volume: 30
  start-page: 845
  year: 2011
  ident: 10.1016/j.reth.2020.07.007_bib105
  article-title: Human platelet-rich plasma stimulates migration and chondrogenic differentiation of human subchondral progenitor cells
  publication-title: J Orthop Res
  doi: 10.1002/jor.22005
– volume: 16
  start-page: S1
  year: 2008
  ident: 10.1016/j.reth.2020.07.007_bib82
  article-title: Current concepts in the pathogenesis of osteoarthritis
  publication-title: Osteoarthritis Cartilage
  doi: 10.1016/j.joca.2008.06.025
– volume: 19
  start-page: 45
  issue: 8
  year: 2017
  ident: 10.1016/j.reth.2020.07.007_bib85
  article-title: Innate immune responses and osteoarthritis
  publication-title: Curr Rheumatol Rep
  doi: 10.1007/s11926-017-0672-6
– year: 2019
  ident: 10.1016/j.reth.2020.07.007_bib117
  article-title: Stem cells for musculoskeletal diseases
– volume: 33
  start-page: 7008
  year: 2012
  ident: 10.1016/j.reth.2020.07.007_bib126
  article-title: Comparative evaluation of MSCs from bone marrow and adipose tissue seeded in PRP-derived scaffold for cartilage regeneration
  publication-title: Biomaterials
  doi: 10.1016/j.biomaterials.2012.06.058
– volume: 149
  start-page: 1424
  year: 1992
  ident: 10.1016/j.reth.2020.07.007_bib12
  article-title: Alpha 4/beta 1 integrin (VLA-4) ligands in arthritis. Vascular cell adhesion molecule-1 expression in synovium and on fibroblast-like synoviocytes
  publication-title: J Immunol
  doi: 10.4049/jimmunol.149.4.1424
– volume: 6
  start-page: 5405
  year: 2014
  ident: 10.1016/j.reth.2020.07.007_bib102
  article-title: Does intra articular platelet rich plasma injection improve function, pain and quality of life in patients with osteoarthritis of the knee? A randomized clinical trial
  publication-title: Orthop Rev
  doi: 10.4081/or.2014.5405
– volume: 3
  start-page: 229
  year: 2008
  ident: 10.1016/j.reth.2020.07.007_bib20
  article-title: All MSCs are pericytes?
  publication-title: Cell Stem Cell
  doi: 10.1016/j.stem.2008.08.008
– volume: 6
  start-page: 206
  issue: 2
  year: 2013
  ident: 10.1016/j.reth.2020.07.007_bib43
  article-title: Biological baseline of joint self-repair procedures
  publication-title: Curr Aging Sci
  doi: 10.2174/18746098112059990029
– volume: 469
  start-page: 2696
  issue: 10
  year: 2011
  ident: 10.1016/j.reth.2020.07.007_bib118
  article-title: Clinical cartilage restoration: evolution and overview
  publication-title: Clin Orthop Relat Res
  doi: 10.1007/s11999-010-1764-z
– volume: 30
  start-page: 160
  year: 2018
  ident: 10.1016/j.reth.2020.07.007_bib60
  article-title: Epidemiology of osteoarthritis: literature update
  publication-title: Curr Opin Rheumatol
  doi: 10.1097/BOR.0000000000000479
– volume: 5
  start-page: 100
  year: 2011
  ident: 10.1016/j.reth.2020.07.007_bib8
  article-title: The normal synovium
  publication-title: Open Rheumatol J
  doi: 10.2174/1874312901105010100
– volume: 32
  start-page: 1349
  issue: 10
  year: 2014
  ident: 10.1016/j.reth.2020.07.007_bib113
  article-title: Autologous protein solution prepared from the blood of osteoarthritic patients contains an enhanced profile of anti-inflammatory cytokines and anabolic growth factors
  publication-title: J Orthop Res
  doi: 10.1002/jor.22671
– year: 2019
  ident: 10.1016/j.reth.2020.07.007_bib115
  article-title: Platelet-rich plasma in osteoarthritis treatment: review of current evidence
  publication-title: Ther Adv Chronic Dis
  doi: 10.1177/2040622319825567
– start-page: 7412304
  year: 2018
  ident: 10.1016/j.reth.2020.07.007_bib41
  article-title: Intervertebral disc-derived stem/progenitor cells as a promising cell source for intervertebral disc regeneration
  publication-title: Stem Cell Int
– volume: 67
  start-page: 56
  year: 2017
  ident: 10.1016/j.reth.2020.07.007_bib135
  article-title: MSC exosome as a cell-free MSC therapy for cartilage regeneration: implications for osteoarthritis treatment
  publication-title: Semin Cell Dev Biol
  doi: 10.1016/j.semcdb.2016.11.008
– volume: 5
  start-page: 351
  issue: 3
  year: 2014
  ident: 10.1016/j.reth.2020.07.007_bib100
  article-title: Intraarticular injections (corticosteroid, hyaluronic acid, platelet rich plasma) for the knee osteoarthritis
  publication-title: World J Orthoped
  doi: 10.5312/wjo.v5.i3.351
– volume: 48
  start-page: 2173
  year: 2003
  ident: 10.1016/j.reth.2020.07.007_bib66
  article-title: Inflammation and angiogenesis in osteoarthritis
  publication-title: Arthritis Rheum
  doi: 10.1002/art.11094
– volume: 25
  start-page: 958
  issue: 3
  year: 2017
  ident: 10.1016/j.reth.2020.07.007_bib112
  article-title: Multiple PRP injections are more effective than single injections and hyaluronic acid in knees with early osteoarthritis: a randomized, double-blind, placebo-controlled trial
  publication-title: Knee Surg Sports Traumatol Arthrosc
  doi: 10.1007/s00167-015-3705-6
– volume: 11
  start-page: 2189-2196
  year: 2018
  ident: 10.1016/j.reth.2020.07.007_bib137
  article-title: Knee osteoarthritis: pathophysiology and current treatment modalities
  publication-title: J Pain Res
– volume: 5
  start-page: 77
  issue: 2
  year: 2013
  ident: 10.1016/j.reth.2020.07.007_bib49
  article-title: Role of inflammation in the pathogenesis of osteoarthritis: latest findings and interpretations
  publication-title: Ther Adv Musculoskelet Dis
  doi: 10.1177/1759720X12467868
– volume: 11
  start-page: 373
  year: 2010
  ident: 10.1016/j.reth.2020.07.007_bib93
  article-title: The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors
  publication-title: Nat Immunol
  doi: 10.1038/ni.1863
– volume: 103
  start-page: 1283
  year: 2006
  ident: 10.1016/j.reth.2020.07.007_bib123
  article-title: Mitochondrial transfer between cells can rescue aerobic respiration
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.0510511103
– year: 2019
  ident: 10.1016/j.reth.2020.07.007_bib28
  article-title: Mesenchymal stem cells in regenerative medicine
– volume: 54
  start-page: 1222
  issue: 4
  year: 2006
  ident: 10.1016/j.reth.2020.07.007_bib31
  article-title: Potent induction of chondrocytic differentiation of human adipose-derived adult stem cells by bone morphogenetic protein 6
  publication-title: Arthritis Rheum
  doi: 10.1002/art.21779
– volume: 11
  start-page: 7747
  issue: 3
  year: 2019
  ident: 10.1016/j.reth.2020.07.007_bib116
  article-title: Use of intraarticular injections of platelet-rich plasma in the treatment of knee osteoarthritis: a review article
  publication-title: Orthop Rev
  doi: 10.4081/or.2019.7747
– volume: 131
  start-page: 324
  issue: 2
  year: 2007
  ident: 10.1016/j.reth.2020.07.007_bib21
  article-title: Self-renewing osteoprogenitors in bone marrow sinusoids can organize a hematopoietic microenvironment
  publication-title: Cell
  doi: 10.1016/j.cell.2007.08.025
– volume: 44
  start-page: 7
  year: 2005
  ident: 10.1016/j.reth.2020.07.007_bib84
  article-title: Osteoarthritis, angiogenesis and inflammation
  publication-title: Rheumatology
  doi: 10.1093/rheumatology/keh344
– volume: 11
  start-page: 693-703
  issue: 7
  year: 2016
  ident: 10.1016/j.reth.2020.07.007_bib130
  article-title: Adipose-derived stem cells in cartilage regeneration: current perspectives
  publication-title: Regen Med
  doi: 10.2217/rme-2016-0077
SSID ssj0001851298
Score 2.4040723
SecondaryResourceType review_article
Snippet Osteoarthritis (OA) is the most common chronic musculoskeletal disorder. It can affect any joint and is the most frequent single cause of disability in older...
Osteoarthritis ( ) is the most common chronic musculoskeletal disorder. It can affect any joint and is the most frequent single cause of disability in older...
Osteoarthritis ( OA ) is the most common chronic musculoskeletal disorder. It can affect any joint and is the most frequent single cause of disability in older...
SourceID doaj
pubmedcentral
proquest
pubmed
crossref
elsevier
SourceType Open Website
Open Access Repository
Aggregation Database
Index Database
Enrichment Source
Publisher
StartPage 149
SubjectTerms Degenerative osteoarthritis
Early OA
MSCs
PRP
Review
Tissue Regeneration
Title Degenerative osteoarthritis a reversible chronic disease
URI https://dx.doi.org/10.1016/j.reth.2020.07.007
https://www.ncbi.nlm.nih.gov/pubmed/33426213
https://www.proquest.com/docview/2476850233
https://pubmed.ncbi.nlm.nih.gov/PMC7770340
https://doaj.org/article/7cbadd63ff4c481180a2ab6d5f535b0f
Volume 15
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3dSxwxEA_Fp74UP6qe1ZKC-CKL2SSb7D3aVpGKQqGCbyGffqB75bx78L93Jtk77iroS1-WZb9nMpP5JZn9DSH7QqbgeG2rJrFYyRDrqhWCV5Z5p5x2bcw8BReX6uxK_rpurhdKfWFOWKEHLoo70t6BCyqRkvSyRcIyy61ToUmNaBxL2PtCzFsYTOXZlRYDWS5HBwijEpzJ_o-Zktw1jhNcieAsM3diLdmFqJTJ-5eC02vw-W8O5UJQOl0ln3o0SY-LFGvkQ-zWycZxByPpx2d6QHN-Z5443yDtz3iTOaaxg6P4b8cIpL_NpEbUUqRyGoN_PETqC2Eu7RdvPpOr05M_P86qvm5C5QEPTSrvpbcQ-O2wFaB9x5PnXIfAkgXtSVCnk65WUXOVtIrJyhD8UHLY5y4kITbJSjfq4jahdbSNC62qA_LY1EMXpR0GwFSBKQe-PCD1TG_G96TiWNviwcyyx-4N6tqgrg3DtW49IIfze_4WSo03r_6OzTG_Eumw8wEwEtMbiXnPSAakmTWm6ZFFQQzwqLs3X_5t1vIG3A7XUmwXR9MnwyWM0xoAPGJAtoolzD9RCKT5r-GMXrKRJRmWz3R3t5naW2vogSXb-R9CfyEfUZSSe7NLVibjadwDBDVxX7OzwPb8d_sCXU0b-A
linkProvider Directory of Open Access Journals
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Degenerative+osteoarthritis+a+reversible+chronic+disease&rft.jtitle=Regenerative+therapy&rft.au=Di+Nicola%2C+V.&rft.date=2020-12-01&rft.pub=Japanese+Society+for+Regenerative+Medicine&rft.eissn=2352-3204&rft.volume=15&rft.spage=149&rft.epage=160&rft_id=info:doi/10.1016%2Fj.reth.2020.07.007&rft_id=info%3Apmid%2F33426213&rft.externalDocID=PMC7770340
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2352-3204&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2352-3204&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2352-3204&client=summon