Matrix Gla protein is associated with coronary artery calcification as assessed by electron-beam computed tomography

• Published in: Thrombosis and haemostasis Vol. 91; no. 4; p. 790
• Main Authors: Jono, Shuichi, Ikari, Yuji, Vermeer, Cees, Dissel, Paul, Hasegawa, Kotaro, Shioi, Atsushi, Taniwaki, Hiromichi, Kizu, Akane, Nishizawa, Yoshiki, Saito, Shigeru
• Format: Journal Article
• Language: English
• Published: Germany 01.04.2004
• Subjects: Aged; Calcinosis - etiology; Calcium-Binding Proteins - blood; Calcium-Binding Proteins - physiology; Coronary Artery Disease - blood; Coronary Artery Disease - etiology; Coronary Artery Disease - pathology; Coronary Vessels - pathology; Extracellular Matrix Proteins - blood; Extracellular Matrix Proteins - physiology; Female; Humans; Male; Matrix Gla Protein; Middle Aged; Risk Factors; Severity of Illness Index; Tomography, X-Ray Computed

Matrix Gla protein (MGP) is an extracellular matrix protein with wide tissue distribution. It has been demonstrated that the expression of MGP is detected not only in the normal blood vessels but also calcified atherosclerotic plaques, and that MGP deficient mice develop extensive arterial calcifica...