HBx-induced degradation of Smc5/6 complex impairs homologous recombination-mediated repair of damaged DNA

• Published in: Journal of hepatology Vol. 76; no. 1; pp. 53 - 62
• Main Authors: Sekiba, Kazuma, Otsuka, Motoyuki, Funato, Kazuyoshi, Miyakawa, Yu, Tanaka, Eri, Seimiya, Takahiro, Yamagami, Mari, Tsutsumi, Takeya, Okushin, Kazuya, Miyakawa, Kei, Ryo, Akihide, Koike, Kazuhiko
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.01.2022; Elsevier Science Ltd
• Subjects: Animals; Carcinoma, Hepatocellular - complications; Carcinoma, Hepatocellular - pathology; cccDNA; Cell Cycle Proteins - adverse effects; Chromosomal Proteins, Non-Histone - adverse effects; Chromosome 5; CRISPR; DDB1; Degradation; Deoxyribonucleic acid; Disease Models, Animal; DNA; DNA damage; DNA repair; Genetic transformation; HBx; Hepatocellular carcinoma; Homologous recombination; Liver - drug effects; Liver - pathology; Liver Neoplasms - complications; Liver Neoplasms - pathology; Mice; Nitazoxanide; Recombinational DNA Repair - drug effects; Recombinational DNA Repair - immunology; Statistics, Nonparametric; Trans-Activators - drug effects; Transcription; Transgenic mice; Viral Regulatory and Accessory Proteins - drug effects; DDB1; Nitazoxanide; cccDNA; DNA damage; HBx

HBV causes hepatocellular carcinoma (HCC). While it was recently shown that the ability of HBV X protein (HBx) to impair the Smc5/6 (structural maintenance of chromosome 5/6) complex is important for viral transcription, HBx is also a potent driver of HCC. However, the mechanism by which HBx express...