The biological basis and function of GNAS mutation in pseudomyxoma peritonei: a review

• Published in: Journal of cancer research and clinical oncology Vol. 146; no. 9; pp. 2179 - 2188
• Main Authors: Lin, Yu-Lin, Ma, Ru, Li, Yan
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.09.2020; Springer Nature B.V
• Subjects: Ascites; Cancer Research; Cell proliferation; Enzymatic activity; Genomes; Guanine; Guanine nucleotide-binding protein; Guanosine triphosphate; Hematology; Internal Medicine; Jelly belly protein; Malignancy; Medicine; Medicine & Public Health; Mucin; Mutation; Oncology; Peritoneum; Phosphoric acid; Protein kinase A; Proteins; Review – Cancer Research; Reviews; Secretion; Signal transduction; Tumors; Mucin; Signaling pathway; Gene mutation; Pseudomyxoma peritonei

Purpose Pseudomyxoma peritonei (PMP) is a rare clinical malignancy syndrome characterized by the uncontrollable accumulation of copious mucinous ascites in the peritoneal cavity, resulting in “jelly belly”. The mechanism of tumor progression and mucin hypersecretion remains largely unknown, but GNAS...