CD40LG duplication-associated autoimmune disease is silenced by nonrandom X-chromosome inactivation

• Published in: Journal of allergy and clinical immunology Vol. 141; no. 6; pp. 2308 - 2311.e7
• Main Authors: Le Coz, Carole, Trofa, Melissa, Syrett, Camille M., Martin, Anna, Jyonouchi, Harumi, Jyonouchi, Soma, Anguera, Montserrat C., Romberg, Neil
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.06.2018; Elsevier Limited
• Subjects: Adult; Apoptosis; Autoimmune diseases; Autoimmune Diseases - genetics; CD40 Ligand - genetics; Chromosome Duplication - genetics; Chromosomes; Deoxyribonucleic acid; Disease; DNA; DNA methylation; Epigenetics; Female; Females; Genes; Genomics; Humans; Immunoglobulins; Infant; Laboratories; Lymphocytes; Male; Mutation; Pedigree; X Chromosome Inactivation - genetics
• ISSN: 0091-6749; 1097-6825; 1097-6825
• DOI: 10.1016/j.jaci.2018.02.010

Furthermore, in heterologous cocultures, anti-CD3/anti-CD28–stimulated III.1's CD4+ T cells compelled control naive B cells to express more activation-induced cytidine deaminase transcripts (Fig 1, E) and undergo more class-switching than when cocultured with stimulated heterologous control CD4...