Astaxanthin Promotes the Survival of Adipose-Derived Stem Cells by Alleviating Oxidative Stress via Activating the Nrf2 Signaling Pathway

• Published in: International journal of molecular sciences Vol. 24; no. 4; p. 3850
• Main Authors: Yang, Chang-Sheng, Guo, Xiao-Shuang, Yue, Ying-Ying, Wang, Yu, Jin, Xiao-Lei
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.02.2023; MDPI
• Subjects: Apoptosis; Astaxanthin; BAX protein; Bcl-2 protein; Bcl-x protein; Caspase 3 - metabolism; Caspase-3; Collagen (type I); Collagen (type II); Cyclin D1; Extracellular matrix; fat grafting; Grafting; Grafts; Health aspects; Humans; Interleukin 6; Membrane potential; mesenchymal stem cell; Mesenchymal Stem Cells - metabolism; Microenvironments; Mitochondria; NF-E2-Related Factor 2 - metabolism; Nrf2 signaling pathway; Oxidative stress; Oxidative Stress - drug effects; Proteins; Reconstructive surgery; Signal Transduction; Stem cells; Surgery; Survival; Transplantation; Tumor necrosis factor-α; Xanthophylls; Xanthophylls - pharmacology; United Kingdom; Illinois; China; fat grafting; mesenchymal stem cell; apoptosis; Nrf2 signaling pathway; oxidative stress; astaxanthin

The survival of free fat grafts is dependent primarily on adipose-derived stem cells (ADSCs); however, ADSCs are susceptible to oxidative stress in the recipient area. Astaxanthin (Axt) is a natural xanthophyll carotenoid with potent antioxidant properties and numerous clinical applications. To date...