Serious obstetric complications interact with hypoxia-regulated/vascular-expression genes to influence schizophrenia risk

• Published in: Molecular psychiatry Vol. 13; no. 9; pp. 873 - 877
• Main Authors: Nicodemus, K K, Marenco, S, Batten, A J, Vakkalanka, R, Egan, M F, Straub, R E, Weinberger, D R
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.09.2008; Nature Publishing Group
• Subjects: Adult and adolescent clinical studies; AKT1 protein; Behavioral Sciences; Biological and medical sciences; Biological Psychology; Brain-derived neurotrophic factor; Cesarean section; Diagnosis; Epistasis; Etiology; Families & family life; Family Health; Female; Fetuses; Gene Expression Regulation - physiology; Genes; Genetic aspects; Gestational age; Humans; Hypoxia; Hypoxia-Ischemia, Brain - embryology; Hypoxia-Ischemia, Brain - genetics; Hypoxia-Ischemia, Brain - physiopathology; Linkage Disequilibrium; Logistic Models; Male; Medical sciences; Medicine; Medicine & Public Health; Mental disorders; Mental health; Neurosciences; Obstetric Labor Complications; Obstetrics; Odds Ratio; original-article; Pharmacotherapy; Physiological aspects; Polymorphism, Single Nucleotide; Pregnancy; Proto-Oncogene Proteins c-akt - genetics; Psychiatry; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Psychoses; Psychosis; Regression analysis; Risk Factors; Schizophrenia; Schizophrenia - etiology; Schizophrenia - genetics; Single-nucleotide polymorphism; Statistical analysis; Surveys and Questionnaires; Tumor necrosis factor-α; United States; United States > US; obstetric complications; hypoxia; AKT1; schizophrenia; genes; Psychosis; Oxygen; Gene; Schizophrenia; Genetics; Complication; Hypoxia; Genetic determinism; Obstetrics

The etiology of schizophrenia is thought to include both epistasis and gene-environment interactions. We sought to test whether a set of schizophrenia candidate genes regulated by hypoxia or involved in vascular function in the brain (AKT1, BDNF, CAPON, CHRNA7, COMT, DTNBP1, GAD1, GRM3, NOTCH4, NRG1...