ABCG1 influences the brain cholesterol biosynthetic pathway but does not affect amyloid precursor protein or apolipoprotein E metabolism in vivo

• Published in: Journal of lipid research Vol. 49; no. 6; pp. 1254 - 1267
• Main Authors: Burgess, Braydon L., Parkinson, Pamela F., Racke, Margaret M., Hirsch-Reinshagen, Veronica, Fan, Jianjia, Wong, Charmaine, Stukas, Sophie, Theroux, Louise, Chan, Jeniffer Y., Donkin, James, Wilkinson, Anna, Balik, Danielle, Christie, Brian, Poirier, Judes, Lütjohann, Dieter, DeMattos, Ronald B., Wellington, Cheryl L.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.06.2008; American Society for Biochemistry and Molecular Biology; Elsevier
• Subjects: Amyloid beta-Protein Precursor - metabolism; Animals; Apolipoproteins E - metabolism; ATP Binding Cassette Transporter, Subfamily G, Member 1; ATP-Binding Cassette Transporters - physiology; ATPase binding cassette transporter; Base Sequence; Biological Transport; Brain - metabolism; Cells, Cultured; central nervous system; Cholesterol - biosynthesis; DNA Primers; DNA-Binding Proteins - metabolism; lipid; Lipoproteins - physiology; Liver X Receptors; Mice; Orphan Nuclear Receptors; Receptors, Cytoplasmic and Nuclear - metabolism; Reverse Transcriptase Polymerase Chain Reaction; lipid; ATPase binding cassette transporter; central nervous system

Cholesterol homeostasis is of emerging therapeutic importance for Alzheimer's disease (AD). Agonists of liver-X-receptors (LXRs) stimulate several genes that regulate cholesterol homeostasis, and synthetic LXR agonists decrease neuropathological and cognitive phenotypes in AD mouse models. The...