Elective nodal irradiation mitigates local and systemic immunity generated by combination radiation and immunotherapy in head and neck tumors

In the setting of conventional radiation therapy, even when combined with immunotherapy, head and neck cancer often recurs locally and regionally. Elective nodal irradiation (ENI) is commonly employed to decrease regional recurrence. Given our developing understanding that immune cells are radio-sen...

Full description

Saved in:
Bibliographic Details
Published inNature communications Vol. 13; no. 1; pp. 7015 - 18
Main Authors Darragh, Laurel B, Gadwa, Jacob, Pham, Tiffany T, Van Court, Benjamin, Neupert, Brooke, Olimpo, Nicholas A, Nguyen, Khoa, Nguyen, Diemmy, Knitz, Michael W, Hoen, Maureen, Corbo, Sophia, Joshi, Molishree, Zhuang, Yonghua, Amann, Maria, Wang, Xiao-Jing, Dow, Steven, Kedl, Ross M, Samedi, Von, Boss, Mary-Keara, Karam, Sana D
Format Journal Article
LanguageEnglish
Published England Nature Publishing Group 16.11.2022
Nature Publishing Group UK
Nature Portfolio
Subjects
Antigens
Cancer
Combined Modality Therapy
Epitopes
Head & neck cancer
Head and neck carcinoma
Head and Neck Neoplasms - radiotherapy
Humans
Immune response
Immune system
Immunity
Immunotherapy
Irradiation
Lymph Node Excision
Lymph nodes
Lymphocytes
Lymphocytes T
Metastases
Priming
Radiation
Radiation therapy
Regional development
Sentinel Lymph Node
Squamous cell carcinoma
Tumors
Online AccessGet full text

Cover

Abstract In the setting of conventional radiation therapy, even when combined with immunotherapy, head and neck cancer often recurs locally and regionally. Elective nodal irradiation (ENI) is commonly employed to decrease regional recurrence. Given our developing understanding that immune cells are radio-sensitive, and that T cell priming occurs in the draining lymph nodes (DLNs), we hypothesize that radiation therapy directed at the primary tumor only will increase the effectiveness of immunotherapies. We find that ENI increases local, distant, and metastatic tumor growth. Multi-compartmental analysis of the primary/distant tumor, the DLNs, and the blood shows that ENI decreases the immune response systemically. Additionally, we find that ENI decreases antigen-specific T cells and epitope spreading. Treating the primary tumor with radiation and immunotherapy, however, fails to reduce regional recurrence, but this is reversed by either concurrent sentinel lymph node resection or irradiation. Our data support using lymphatic sparing radiation therapy for head and neck cancer.
AbstractList Neck dissection and/or elective nodal irradiation (ENI) are commonly performed in patients with head and neck squamous cell carcinoma (HNSCC) to minimize local and regional recurrence. However, here the authors show that ENI blunts the immune response to combined radiation and immunotherapy, increasing local and distant tumor growth in HNSCC preclinical models.
In the setting of conventional radiation therapy, even when combined with immunotherapy, head and neck cancer often recurs locally and regionally. Elective nodal irradiation (ENI) is commonly employed to decrease regional recurrence. Given our developing understanding that immune cells are radio-sensitive, and that T cell priming occurs in the draining lymph nodes (DLNs), we hypothesize that radiation therapy directed at the primary tumor only will increase the effectiveness of immunotherapies. We find that ENI increases local, distant, and metastatic tumor growth. Multi-compartmental analysis of the primary/distant tumor, the DLNs, and the blood shows that ENI decreases the immune response systemically. Additionally, we find that ENI decreases antigen-specific T cells and epitope spreading. Treating the primary tumor with radiation and immunotherapy, however, fails to reduce regional recurrence, but this is reversed by either concurrent sentinel lymph node resection or irradiation. Our data support using lymphatic sparing radiation therapy for head and neck cancer.In the setting of conventional radiation therapy, even when combined with immunotherapy, head and neck cancer often recurs locally and regionally. Elective nodal irradiation (ENI) is commonly employed to decrease regional recurrence. Given our developing understanding that immune cells are radio-sensitive, and that T cell priming occurs in the draining lymph nodes (DLNs), we hypothesize that radiation therapy directed at the primary tumor only will increase the effectiveness of immunotherapies. We find that ENI increases local, distant, and metastatic tumor growth. Multi-compartmental analysis of the primary/distant tumor, the DLNs, and the blood shows that ENI decreases the immune response systemically. Additionally, we find that ENI decreases antigen-specific T cells and epitope spreading. Treating the primary tumor with radiation and immunotherapy, however, fails to reduce regional recurrence, but this is reversed by either concurrent sentinel lymph node resection or irradiation. Our data support using lymphatic sparing radiation therapy for head and neck cancer.
In the setting of conventional radiation therapy, even when combined with immunotherapy, head and neck cancer often recurs locally and regionally. Elective nodal irradiation (ENI) is commonly employed to decrease regional recurrence. Given our developing understanding that immune cells are radio-sensitive, and that T cell priming occurs in the draining lymph nodes (DLNs), we hypothesize that radiation therapy directed at the primary tumor only will increase the effectiveness of immunotherapies. We find that ENI increases local, distant, and metastatic tumor growth. Multi-compartmental analysis of the primary/distant tumor, the DLNs, and the blood shows that ENI decreases the immune response systemically. Additionally, we find that ENI decreases antigen-specific T cells and epitope spreading. Treating the primary tumor with radiation and immunotherapy, however, fails to reduce regional recurrence, but this is reversed by either concurrent sentinel lymph node resection or irradiation. Our data support using lymphatic sparing radiation therapy for head and neck cancer.
Abstract In the setting of conventional radiation therapy, even when combined with immunotherapy, head and neck cancer often recurs locally and regionally. Elective nodal irradiation (ENI) is commonly employed to decrease regional recurrence. Given our developing understanding that immune cells are radio-sensitive, and that T cell priming occurs in the draining lymph nodes (DLNs), we hypothesize that radiation therapy directed at the primary tumor only will increase the effectiveness of immunotherapies. We find that ENI increases local, distant, and metastatic tumor growth. Multi-compartmental analysis of the primary/distant tumor, the DLNs, and the blood shows that ENI decreases the immune response systemically. Additionally, we find that ENI decreases antigen-specific T cells and epitope spreading. Treating the primary tumor with radiation and immunotherapy, however, fails to reduce regional recurrence, but this is reversed by either concurrent sentinel lymph node resection or irradiation. Our data support using lymphatic sparing radiation therapy for head and neck cancer.
In the setting of conventional radiation therapy, even when combined with immunotherapy, head and neck cancer often recurs locally and regionally. Elective nodal irradiation (ENI) is commonly employed to decrease regional recurrence. Given our developing understanding that immune cells are radio-sensitive, and that T cell priming occurs in the draining lymph nodes (DLNs), we hypothesize that radiation therapy directed at the primary tumor only will increase the effectiveness of immunotherapies. We find that ENI increases local, distant, and metastatic tumor growth. Multi-compartmental analysis of the primary/distant tumor, the DLNs, and the blood shows that ENI decreases the immune response systemically. Additionally, we find that ENI decreases antigen-specific T cells and epitope spreading. Treating the primary tumor with radiation and immunotherapy, however, fails to reduce regional recurrence, but this is reversed by either concurrent sentinel lymph node resection or irradiation. Our data support using lymphatic sparing radiation therapy for head and neck cancer.Neck dissection and/or elective nodal irradiation (ENI) are commonly performed in patients with head and neck squamous cell carcinoma (HNSCC) to minimize local and regional recurrence. However, here the authors show that ENI blunts the immune response to combined radiation and immunotherapy, increasing local and distant tumor growth in HNSCC preclinical models.
In the setting of conventional radiation therapy, even when combined with immunotherapy, head and neck cancer often recurs locally and regionally. Elective nodal irradiation (ENI) is commonly employed to decrease regional recurrence. Given our developing understanding that immune cells are radio-sensitive, and that T cell priming occurs in the draining lymph nodes (DLNs), we hypothesize that radiation therapy directed at the primary tumor only will increase the effectiveness of immunotherapies. We find that ENI increases local, distant, and metastatic tumor growth. Multi-compartmental analysis of the primary/distant tumor, the DLNs, and the blood shows that ENI decreases the immune response systemically. Additionally, we find that ENI decreases antigen-specific T cells and epitope spreading. Treating the primary tumor with radiation and immunotherapy, however, fails to reduce regional recurrence, but this is reversed by either concurrent sentinel lymph node resection or irradiation. Our data support using lymphatic sparing radiation therapy for head and neck cancer. Neck dissection and/or elective nodal irradiation (ENI) are commonly performed in patients with head and neck squamous cell carcinoma (HNSCC) to minimize local and regional recurrence. However, here the authors show that ENI blunts the immune response to combined radiation and immunotherapy, increasing local and distant tumor growth in HNSCC preclinical models.
ArticleNumber 7015
Author Nguyen, Diemmy
Nguyen, Khoa
Zhuang, Yonghua
Pham, Tiffany T
Knitz, Michael W
Hoen, Maureen
Van Court, Benjamin
Karam, Sana D
Wang, Xiao-Jing
Dow, Steven
Neupert, Brooke
Kedl, Ross M
Darragh, Laurel B
Corbo, Sophia
Boss, Mary-Keara
Joshi, Molishree
Olimpo, Nicholas A
Gadwa, Jacob
Amann, Maria
Samedi, Von
Author_xml – sequence: 1
  givenname: Laurel B
  orcidid: 0000-0002-6445-7988
  surname: Darragh
  fullname: Darragh, Laurel B
  organization: Department of Immunology and Microbiology, University of Colorado Denver at Anschutz Medical Campus, Aurora, CO, USA
– sequence: 2
  givenname: Jacob
  surname: Gadwa
  fullname: Gadwa, Jacob
  organization: Department of Radiation Oncology, University of Colorado Denver at Anschutz Medical Campus, Aurora, CO, USA
– sequence: 3
  givenname: Tiffany T
  surname: Pham
  fullname: Pham, Tiffany T
  organization: Department of Otolaryngology Head and Neck Surgery, University of Colorado Denver at Anschutz Medical Campus, Aurora, CO, USA
– sequence: 4
  givenname: Benjamin
  surname: Van Court
  fullname: Van Court, Benjamin
  organization: Department of Radiation Oncology, University of Colorado Denver at Anschutz Medical Campus, Aurora, CO, USA
– sequence: 5
  givenname: Brooke
  surname: Neupert
  fullname: Neupert, Brooke
  organization: Department of Radiation Oncology, University of Colorado Denver at Anschutz Medical Campus, Aurora, CO, USA
– sequence: 6
  givenname: Nicholas A
  surname: Olimpo
  fullname: Olimpo, Nicholas A
  organization: Department of Radiation Oncology, University of Colorado Denver at Anschutz Medical Campus, Aurora, CO, USA
– sequence: 7
  givenname: Khoa
  surname: Nguyen
  fullname: Nguyen, Khoa
  organization: Department of Pathology, University of Colorado Denver at Anschutz Medical Campus, Aurora, CO, USA
– sequence: 8
  givenname: Diemmy
  surname: Nguyen
  fullname: Nguyen, Diemmy
  organization: Department of Radiation Oncology, University of Colorado Denver at Anschutz Medical Campus, Aurora, CO, USA
– sequence: 9
  givenname: Michael W
  orcidid: 0000-0002-5786-9837
  surname: Knitz
  fullname: Knitz, Michael W
  organization: Department of Radiation Oncology, University of Colorado Denver at Anschutz Medical Campus, Aurora, CO, USA
– sequence: 10
  givenname: Maureen
  surname: Hoen
  fullname: Hoen, Maureen
  organization: Department of Radiation Oncology, University of Colorado Denver at Anschutz Medical Campus, Aurora, CO, USA
– sequence: 11
  givenname: Sophia
  surname: Corbo
  fullname: Corbo, Sophia
  organization: Department of Radiation Oncology, University of Colorado Denver at Anschutz Medical Campus, Aurora, CO, USA
– sequence: 12
  givenname: Molishree
  surname: Joshi
  fullname: Joshi, Molishree
  organization: Department of Pharmacology, University of Colorado Denver at Anschutz Medical campus, Aurora, CO, USA
– sequence: 13
  givenname: Yonghua
  surname: Zhuang
  fullname: Zhuang, Yonghua
  organization: Department of Pediatrics, Cancer Center Biostatistics Core, University of Colorado Anschutz Medical campus, Aurora, CO, USA
– sequence: 14
  givenname: Maria
  surname: Amann
  fullname: Amann, Maria
  organization: Roche Innovation Center Zurich, Roche Pharmaceutical Research and Early Development (pRED) Schlieren, Zurich, Switzerland
– sequence: 15
  givenname: Xiao-Jing
  orcidid: 0000-0001-8695-7361
  surname: Wang
  fullname: Wang, Xiao-Jing
  organization: Veterans Affairs Medical Center, VA Eastern Colorado Health Care System, Aurora, CO, 80045, USA
– sequence: 16
  givenname: Steven
  surname: Dow
  fullname: Dow, Steven
  organization: Department of Radiation Oncology, Colorado State University, Fort Collins, Colorado. Campus, Aurora, CO, USA
– sequence: 17
  givenname: Ross M
  surname: Kedl
  fullname: Kedl, Ross M
  organization: Department of Radiation Oncology, University of Colorado Denver at Anschutz Medical Campus, Aurora, CO, USA
– sequence: 18
  givenname: Von
  surname: Samedi
  fullname: Samedi, Von
  organization: Department of Pathology, University of Colorado Denver at Anschutz Medical Campus, Aurora, CO, USA
– sequence: 19
  givenname: Mary-Keara
  surname: Boss
  fullname: Boss, Mary-Keara
  organization: Department of Radiation Oncology, Colorado State University, Fort Collins, Colorado. Campus, Aurora, CO, USA
– sequence: 20
  givenname: Sana D
  orcidid: 0000-0003-1676-5967
  surname: Karam
  fullname: Karam, Sana D
  email: sana.karam@cuanschutz.edu, sana.karam@cuanschutz.edu
  organization: Department of Immunology and Microbiology, University of Colorado Denver at Anschutz Medical Campus, Aurora, CO, USA. sana.karam@cuanschutz.edu
BackLink https://www.ncbi.nlm.nih.gov/pubmed/36385142$$D View this record in MEDLINE/PubMed
BookMark eNpdks9uFSEUxompsbX2BVwYEjduRvk3DGxMTFO1SRM3uiYMMPdynYErMG3mIXxnuXdqbWXDCef7fjmcfC_BSYjBAfAao_cYUfEhM8x41yBCGloL3tw9A2cEMdzgjtCTR_UpuMh5h-qhEgvGXoBTyqloMSNn4PfV6Ezxtw6GaPUIfUrael18DHDyxW90cRmO0dSeDhbmJRc3eQP9NM3BlwVuXHCpqizsF2ji1Puw2v-BDsajPpZt1e4X6APcOm2PneDMT1jmKab8Cjwf9Jjdxf19Dn58vvp--bW5-fbl-vLTTWNa1pZGYyYpYwgbbMUgBCUOk6FDg7QEt6btraVMk54xi7UQVg5UCNdpSSmjwvT0HFyvXBv1Tu2Tn3RaVNReHR9i2iidijejU3Vrpq5L9sZy1gupWc-QsFZqyjl3trI-rqz93E_OGhdK0uMT6NNO8Fu1ibdKci4E4RXw7h6Q4q_Z5aImn40bRx1cnLMiHe0Y57LtqvTtf9JdnFOoqzqouKSSogOQrCqTYs7JDQ_DYKQO4VFreFQNjzqGR91V05vH33iw_I0K_QNCLMTR
CitedBy_id crossref_primary_10_1158_1078_0432_CCR_23_0334
crossref_primary_10_1093_jnci_djad118
crossref_primary_10_1016_j_ccell_2024_05_015
crossref_primary_10_46879_ukroj_4_2023_440_460
crossref_primary_10_3390_jcm13113020
crossref_primary_10_3390_cancers15051608
crossref_primary_10_1016_j_ijrobp_2023_04_029
crossref_primary_10_1084_jem_20232101
crossref_primary_10_1080_2162402X_2023_2174721
crossref_primary_10_1093_bjr_tqae100
crossref_primary_10_1200_JCO_23_02086
crossref_primary_10_2217_imt_2023_0191
crossref_primary_10_1038_s41467_024_49873_y
crossref_primary_10_3390_cancers16020383
crossref_primary_10_1016_j_xcrm_2023_101150
crossref_primary_10_1007_s10585_023_10261_3
crossref_primary_10_1016_j_ijrobp_2023_05_006
crossref_primary_10_1016_j_medj_2024_02_002
crossref_primary_10_3389_fonc_2023_1186479
crossref_primary_10_3389_fonc_2023_1269166
crossref_primary_10_1158_1078_0432_CCR_22_3563
crossref_primary_10_3389_fvets_2023_1202265
crossref_primary_10_3390_app13095643
crossref_primary_10_1002_advs_202304076
crossref_primary_10_1002_hed_27722
crossref_primary_10_1016_j_actbio_2023_05_047
crossref_primary_10_1016_j_semradonc_2023_03_005
crossref_primary_10_1001_jamaoncol_2024_1530
crossref_primary_10_1016_j_soc_2024_04_001
crossref_primary_10_3390_lymphatics1030018
crossref_primary_10_1016_j_canrad_2023_03_004
crossref_primary_10_1016_j_ijrobp_2023_09_035
crossref_primary_10_1001_jamaoncol_2024_1527
crossref_primary_10_3390_life13010006
crossref_primary_10_1016_j_ijrobp_2023_02_047
crossref_primary_10_1136_jitc_2023_008026
crossref_primary_10_1016_j_canrad_2023_06_028
crossref_primary_10_1016_S1470_2045_23_00479_5
crossref_primary_10_1136_jitc_2023_008229
crossref_primary_10_1016_j_radonc_2023_109496
crossref_primary_10_1093_jnci_djae071
crossref_primary_10_3389_froh_2023_1180869
crossref_primary_10_3390_cells13050397
crossref_primary_10_1007_s00262_024_03664_y
crossref_primary_10_1016_j_cej_2023_147465
crossref_primary_10_1200_CCI_23_00058
crossref_primary_10_1186_s12885_023_11503_z
crossref_primary_10_1158_1078_0432_CCR_23_3632
crossref_primary_10_1038_s41571_023_00782_x
crossref_primary_10_1007_s11654_023_00520_w
crossref_primary_10_1038_s41467_023_39383_8
crossref_primary_10_1080_2162402X_2023_2222560
crossref_primary_10_1016_j_ijrobp_2024_04_065
crossref_primary_10_1055_a_2183_5802
crossref_primary_10_3389_fnume_2024_1331364
crossref_primary_10_1016_j_euo_2023_09_011
crossref_primary_10_1016_j_oraloncology_2023_106569
crossref_primary_10_3389_fimmu_2024_1357101
crossref_primary_10_1007_s00106_023_01287_w
Cites_doi 10.1016/j.oraloncology.2021.105642
10.1093/jnci/djz036
10.1016/j.radonc.2022.01.003
10.1136/jitc-2020-001955
10.1080/2162402X.2019.1588085
10.1016/j.annonc.2021.08.2112
10.1158/0008-5472.CAN-12-0903
10.1038/s41568-021-00347-z
10.1158/1078-0432.CCR-17-1425
10.4049/jimmunol.1401571
10.1200/JCO.19.00186
10.1038/s41588-020-0633-2
10.1038/s41586-019-1671-8
10.1038/s41591-022-01851-x
10.3389/fonc.2021.592319
10.1038/s41467-022-31941-w
10.1016/j.cels.2019.04.003
10.1186/s12917-019-2073-8
10.1002/JLB.5RI0220-603RR
10.1172/JCI65856
10.1053/j.seminoncol.2020.09.001
10.3389/fonc.2019.00122
10.1016/j.ejca.2017.05.035
10.1007/s40257-018-0379-0
10.1016/j.bbcan.2020.188439
10.3389/fimmu.2021.643291
10.1186/s40425-017-0216-7
10.1158/1078-0432.CCR-17-3427
10.1038/nature14426
10.3390/cancers13184616
10.3791/59195
10.1158/2326-6066.CIR-16-0107
10.1002/hed.23535
10.1158/1078-0432.CCR-17-3644
10.1038/s41417-020-0183-x
10.4049/jimmunol.1700643
10.1016/j.immuni.2021.08.026
10.3390/ijms22179401
10.1634/theoncologist.2014-0422
10.1073/pnas.1516485113
10.1038/s41586-021-03363-z
10.4049/jimmunol.180.5.3122
10.1016/j.ijrobp.2021.07.1695
10.1200/JCO.20.00290
10.1136/jitc-2021-002568
10.1158/1078-0432.CCR-18-1038
10.1158/1078-0432.CCR-20-0305
10.1016/S1470-2045(20)30737-3
10.1016/j.neo.2022.100812
10.6004/jnccn.2020.0031
10.1172/jci.insight.124507
10.1136/jitc-2020-000867
10.4049/jimmunol.173.7.4443
10.1093/annonc/mdy399
10.1016/j.immuni.2005.02.003
10.1038/s41467-021-21383-1
10.3389/fimmu.2020.586907
10.1016/j.cell.2016.12.022
ContentType Journal Article
Copyright 2022. The Author(s).
The Author(s) 2022. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
The Author(s) 2022
Copyright_xml – notice: 2022. The Author(s).
– notice: The Author(s) 2022. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
– notice: The Author(s) 2022
DBID CGR
CUY
CVF
ECM
EIF
NPM
AAYXX
CITATION
3V.
7QL
7QP
7QR
7SN
7SS
7ST
7T5
7T7
7TM
7TO
7X7
7XB
88E
8AO
8FD
8FE
8FG
8FH
8FI
8FJ
8FK
ABUWG
AFKRA
ARAPS
AZQEC
BBNVY
BENPR
BGLVJ
BHPHI
C1K
CCPQU
DWQXO
FR3
FYUFA
GHDGH
GNUQQ
H94
HCIFZ
K9.
LK8
M0S
M1P
M7P
P5Z
P62
P64
PIMPY
PQEST
PQQKQ
PQUKI
PRINS
RC3
SOI
7X8
5PM
DOA
DOI 10.1038/s41467-022-34676-w
DatabaseName Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
CrossRef
ProQuest Central (Corporate)
Bacteriology Abstracts (Microbiology B)
Calcium & Calcified Tissue Abstracts
Chemoreception Abstracts
Ecology Abstracts
Entomology Abstracts (Full archive)
Environment Abstracts
Immunology Abstracts
Industrial and Applied Microbiology Abstracts (Microbiology A)
Nucleic Acids Abstracts
Oncogenes and Growth Factors Abstracts
Health & Medical Collection
ProQuest Central (purchase pre-March 2016)
Medical Database (Alumni Edition)
ProQuest Pharma Collection
Technology Research Database
ProQuest SciTech Collection
ProQuest Technology Collection
ProQuest Natural Science Collection
Hospital Premium Collection
Hospital Premium Collection (Alumni Edition)
ProQuest Central (Alumni) (purchase pre-March 2016)
ProQuest Central (Alumni Edition)
ProQuest Central
Advanced Technologies & Aerospace Database‎ (1962 - current)
ProQuest Central Essentials
Biological Science Collection
ProQuest Central
Technology Collection
ProQuest Natural Science Collection
Environmental Sciences and Pollution Management
ProQuest One Community College
ProQuest Central Korea
Engineering Research Database
Health Research Premium Collection
Health Research Premium Collection (Alumni)
ProQuest Central Student
AIDS and Cancer Research Abstracts
SciTech Premium Collection
ProQuest Health & Medical Complete (Alumni)
ProQuest Biological Science Collection
Health & Medical Collection (Alumni Edition)
Medical Database
Biological Science Database
Advanced Technologies & Aerospace Database
ProQuest Advanced Technologies & Aerospace Collection
Biotechnology and BioEngineering Abstracts
Publicly Available Content Database
ProQuest One Academic Eastern Edition (DO NOT USE)
ProQuest One Academic
ProQuest One Academic UKI Edition
ProQuest Central China
Genetics Abstracts
Environment Abstracts
MEDLINE - Academic
PubMed Central (Full Participant titles)
DOAJ Directory of Open Access Journals
DatabaseTitle MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
CrossRef
Publicly Available Content Database
ProQuest Central Student
Oncogenes and Growth Factors Abstracts
ProQuest Advanced Technologies & Aerospace Collection
ProQuest Central Essentials
Nucleic Acids Abstracts
SciTech Premium Collection
ProQuest Central China
Environmental Sciences and Pollution Management
Health Research Premium Collection
Natural Science Collection
Biological Science Collection
Chemoreception Abstracts
Industrial and Applied Microbiology Abstracts (Microbiology A)
ProQuest Medical Library (Alumni)
Advanced Technologies & Aerospace Collection
ProQuest Biological Science Collection
ProQuest One Academic Eastern Edition
ProQuest Hospital Collection
ProQuest Technology Collection
Health Research Premium Collection (Alumni)
Biological Science Database
Ecology Abstracts
ProQuest Hospital Collection (Alumni)
Biotechnology and BioEngineering Abstracts
Entomology Abstracts
ProQuest Health & Medical Complete
ProQuest One Academic UKI Edition
Engineering Research Database
ProQuest One Academic
Calcium & Calcified Tissue Abstracts
Technology Collection
Technology Research Database
ProQuest Health & Medical Complete (Alumni)
ProQuest Central (Alumni Edition)
ProQuest One Community College
ProQuest Natural Science Collection
ProQuest Pharma Collection
ProQuest Central
Genetics Abstracts
Health and Medicine Complete (Alumni Edition)
ProQuest Central Korea
Bacteriology Abstracts (Microbiology B)
AIDS and Cancer Research Abstracts
ProQuest SciTech Collection
Advanced Technologies & Aerospace Database
ProQuest Medical Library
Immunology Abstracts
Environment Abstracts
ProQuest Central (Alumni)
MEDLINE - Academic
DatabaseTitleList
MEDLINE - Academic
MEDLINE
CrossRef
Publicly Available Content Database
Database_xml – sequence: 1
  dbid: DOA
  name: DOAJ Directory of Open Access Journals
  url: https://www.doaj.org/
  sourceTypes: Open Website
– sequence: 2
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 3
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
– sequence: 4
  dbid: 8FG
  name: ProQuest Technology Collection
  url: https://search.proquest.com/technologycollection1
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Biology
EISSN 2041-1723
EndPage 18
ExternalDocumentID oai_doaj_org_article_003c3639bcd64b89a4b408dd9a3666ed
10_1038_s41467_022_34676_w
36385142
Genre Research Support, Non-U.S. Gov't
Journal Article
Research Support, N.I.H., Extramural
GrantInformation_xml – fundername: NIDCR NIH HHS
  grantid: R01 DE028420
– fundername: BLRD VA
  grantid: I01 BX003232
– fundername: NCI NIH HHS
  grantid: P30 CA046934
– fundername: NIDCR NIH HHS
  grantid: F31 DE029997
– fundername: BLRD VA
  grantid: IK6 BX005962
– fundername: NIDCR NIH HHS
  grantid: R01 DE028282
– fundername: NIH HHS
  grantid: S10 OD027023
– fundername: NIDDK NIH HHS
  grantid: P30 DK116073
– fundername: NCI NIH HHS
  grantid: P50 CA261605
– fundername: NIDCR NIH HHS
  grantid: R01 DE028529
– fundername: ;
– fundername: ;
  grantid: F31 DE029997; DE028529-01; DE028282-01
– fundername: ;
  grantid: 1P50CA261605-01
– fundername: ;
  grantid: Pilot Grant Award
GroupedDBID ---
0R~
39C
3V.
53G
5VS
70F
7X7
88E
8AO
8FE
8FG
8FH
8FI
8FJ
AAHBH
AAJSJ
ABUWG
ACGFO
ACGFS
ACIWK
ACMJI
ACPRK
ACSMW
ADBBV
ADFRT
ADRAZ
AENEX
AFKRA
AFRAH
AHMBA
AJTQC
ALIPV
ALMA_UNASSIGNED_HOLDINGS
AMTXH
AOIJS
ARAPS
ASPBG
AVWKF
AZFZN
BBNVY
BCNDV
BENPR
BGLVJ
BHPHI
BPHCQ
BVXVI
C6C
CCPQU
CGR
CUY
CVF
DIK
EBLON
EBS
ECM
EE.
EIF
EMOBN
F5P
FEDTE
FYUFA
GROUPED_DOAJ
HCIFZ
HMCUK
HVGLF
HYE
HZ~
KQ8
LK8
M1P
M48
M7P
M~E
NAO
NPM
O9-
OK1
P2P
P62
PIMPY
PQQKQ
PROAC
PSQYO
RNS
RNT
RNTTT
RPM
SNYQT
SV3
TSG
UKHRP
AAYXX
CITATION
7QL
7QP
7QR
7SN
7SS
7ST
7T5
7T7
7TM
7TO
7XB
8FD
8FK
AZQEC
C1K
DWQXO
FR3
GNUQQ
H94
K9.
P64
PQEST
PQUKI
PRINS
RC3
SOI
7X8
5PM
AAADF
AFGXO
ZA5
ID FETCH-LOGICAL-c545t-a14934401c1d8f8832e12f70f9d215c5bdd34a2b44d1a88d9f388e7a933438cb3
IEDL.DBID RPM
ISSN 2041-1723
IngestDate Thu Jul 04 21:08:08 EDT 2024
Tue Sep 17 21:35:10 EDT 2024
Sat Sep 07 16:31:25 EDT 2024
Fri Sep 13 06:30:42 EDT 2024
Fri Aug 23 02:30:46 EDT 2024
Wed Oct 02 05:17:47 EDT 2024
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 1
Language English
License 2022. The Author(s).
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c545t-a14934401c1d8f8832e12f70f9d215c5bdd34a2b44d1a88d9f388e7a933438cb3
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ORCID 0000-0002-6445-7988
0000-0001-8695-7361
0000-0003-1676-5967
0000-0002-5786-9837
OpenAccessLink https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9668826/
PMID 36385142
PQID 2736939306
PQPubID 546298
PageCount 18
ParticipantIDs doaj_primary_oai_doaj_org_article_003c3639bcd64b89a4b408dd9a3666ed
pubmedcentral_primary_oai_pubmedcentral_nih_gov_9668826
proquest_miscellaneous_2737466957
proquest_journals_2736939306
crossref_primary_10_1038_s41467_022_34676_w
pubmed_primary_36385142
PublicationCentury 2000
PublicationDate 2022-11-16
PublicationDateYYYYMMDD 2022-11-16
PublicationDate_xml – month: 11
  year: 2022
  text: 2022-11-16
  day: 16
PublicationDecade 2020
PublicationPlace England
PublicationPlace_xml – name: England
– name: London
PublicationTitle Nature communications
PublicationTitleAlternate Nat Commun
PublicationYear 2022
Publisher Nature Publishing Group
Nature Publishing Group UK
Nature Portfolio
Publisher_xml – name: Nature Publishing Group
– name: Nature Publishing Group UK
– name: Nature Portfolio
References KJ Hiam-Galvez (34676_CR19) 2021; 21
G Manukian (34676_CR1) 2019; 9
34676_CR42
AE Marciscano (34676_CR12) 2018; 24
B Szekely (34676_CR47) 2018; 29
PJ Ulintz (34676_CR45) 2018; 24
34676_CR7
A Gonzalez (34676_CR50) 2018; 19
S Kandula (34676_CR20) 2004; 173
C Hui (34676_CR2) 2021; 11
NY Lee (34676_CR4) 2021; 22
G Kueberuwa (34676_CR16) 2017; 5
A Memarnejadian (34676_CR44) 2017; 199
34676_CR30
JM Schenkel (34676_CR9) 2021; 54
SE Brightman (34676_CR35) 2020; 107
RE Tay (34676_CR32) 2021; 28
A Oweida (34676_CR59) 2018; 24
R Duhen (34676_CR53) 2021; 12
T Matsuda (34676_CR17) 2019; 8
P Brossart (34676_CR23) 2020; 26
PJJ Damen (34676_CR27) 2021; 111
S Kreiter (34676_CR41) 2015; 520
R Saddawi-Konefka (34676_CR14) 2022; 13
T Li (34676_CR34) 2020; 1874
T Hompland (34676_CR48) 2012; 72
S McBride (34676_CR5) 2021; 39
KM van Pul (34676_CR11) 2021; 12
D Dai (34676_CR26) 2022; 168
AP Benechet (34676_CR24) 2016; 113
SB Wong (34676_CR37) 2008; 180
JG Reiter (34676_CR46) 2020; 52
T Gupta (34676_CR43) 2022; 124
I Telarovic (34676_CR31) 2022; 31
RA White (34676_CR56) 2013; 123
F Magnoni (34676_CR49) 2020; 47
A Al-Mamgani (34676_CR29) 2017; 82
M Zuazo (34676_CR33) 2020; 11
JA Contreras (34676_CR52) 2019; 37
JL Campian (34676_CR28) 2014; 36
DG Pfister (34676_CR6) 2020; 18
JN Taroni (34676_CR60) 2019; 8
34676_CR18
34676_CR13
W Wheat (34676_CR25) 2019; 15
34676_CR57
34676_CR58
A Corthay (34676_CR39) 2005; 22
34676_CR10
E Alspach (34676_CR40) 2019; 574
34676_CR54
34676_CR51
Z Zhu (34676_CR38) 2015; 195
GK Pennock (34676_CR3) 2015; 20
J Bourhis (34676_CR55) 2021; 32
T Wang (34676_CR8) 2017; 5
AJ Oweida (34676_CR15) 2019; 111
MH Spitzer (34676_CR21) 2017; 168
M Gerlinger (34676_CR22) 2018; 24
M Platten (34676_CR36) 2021; 592
References_xml – volume: 124
  start-page: 105642
  year: 2022
  ident: 34676_CR43
  publication-title: Oral. Oncol.
  doi: 10.1016/j.oraloncology.2021.105642
  contributor:
    fullname: T Gupta
– volume: 111
  start-page: 1339
  year: 2019
  ident: 34676_CR15
  publication-title: J. Natl Cancer Inst.
  doi: 10.1093/jnci/djz036
  contributor:
    fullname: AJ Oweida
– volume: 168
  start-page: 28
  year: 2022
  ident: 34676_CR26
  publication-title: Radiother. Oncol.
  doi: 10.1016/j.radonc.2022.01.003
  contributor:
    fullname: D Dai
– ident: 34676_CR7
  doi: 10.1136/jitc-2020-001955
– volume: 8
  start-page: e1588085
  year: 2019
  ident: 34676_CR17
  publication-title: Oncoimmunology
  doi: 10.1080/2162402X.2019.1588085
  contributor:
    fullname: T Matsuda
– volume: 32
  start-page: S1283
  year: 2021
  ident: 34676_CR55
  publication-title: Ann. Oncol.
  doi: 10.1016/j.annonc.2021.08.2112
  contributor:
    fullname: J Bourhis
– volume: 72
  start-page: 4899
  year: 2012
  ident: 34676_CR48
  publication-title: Cancer Res.
  doi: 10.1158/0008-5472.CAN-12-0903
  contributor:
    fullname: T Hompland
– volume: 21
  start-page: 345
  year: 2021
  ident: 34676_CR19
  publication-title: Nat. Rev. Cancer
  doi: 10.1038/s41568-021-00347-z
  contributor:
    fullname: KJ Hiam-Galvez
– volume: 24
  start-page: 2214
  year: 2018
  ident: 34676_CR45
  publication-title: Clin. Cancer Res.
  doi: 10.1158/1078-0432.CCR-17-1425
  contributor:
    fullname: PJ Ulintz
– volume: 195
  start-page: 3482
  year: 2015
  ident: 34676_CR38
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.1401571
  contributor:
    fullname: Z Zhu
– volume: 37
  start-page: 2548
  year: 2019
  ident: 34676_CR52
  publication-title: J. Clin. Oncol.
  doi: 10.1200/JCO.19.00186
  contributor:
    fullname: JA Contreras
– volume: 52
  start-page: 692
  year: 2020
  ident: 34676_CR46
  publication-title: Nat. Genet.
  doi: 10.1038/s41588-020-0633-2
  contributor:
    fullname: JG Reiter
– volume: 574
  start-page: 696
  year: 2019
  ident: 34676_CR40
  publication-title: Nature
  doi: 10.1038/s41586-019-1671-8
  contributor:
    fullname: E Alspach
– ident: 34676_CR51
  doi: 10.1038/s41591-022-01851-x
– volume: 11
  start-page: 592319
  year: 2021
  ident: 34676_CR2
  publication-title: Front Oncol.
  doi: 10.3389/fonc.2021.592319
  contributor:
    fullname: C Hui
– ident: 34676_CR42
  doi: 10.1038/s41467-022-31941-w
– volume: 8
  start-page: 380
  year: 2019
  ident: 34676_CR60
  publication-title: Cell Syst.
  doi: 10.1016/j.cels.2019.04.003
  contributor:
    fullname: JN Taroni
– volume: 15
  start-page: 330
  year: 2019
  ident: 34676_CR25
  publication-title: BMC Vet. Res.
  doi: 10.1186/s12917-019-2073-8
  contributor:
    fullname: W Wheat
– volume: 107
  start-page: 625
  year: 2020
  ident: 34676_CR35
  publication-title: J. Leukoc. Biol.
  doi: 10.1002/JLB.5RI0220-603RR
  contributor:
    fullname: SE Brightman
– volume: 123
  start-page: 4390
  year: 2013
  ident: 34676_CR56
  publication-title: J. Clin. Invest.
  doi: 10.1172/JCI65856
  contributor:
    fullname: RA White
– volume: 47
  start-page: 341
  year: 2020
  ident: 34676_CR49
  publication-title: Semin Oncol.
  doi: 10.1053/j.seminoncol.2020.09.001
  contributor:
    fullname: F Magnoni
– volume: 9
  start-page: 122
  year: 2019
  ident: 34676_CR1
  publication-title: Front Oncol.
  doi: 10.3389/fonc.2019.00122
  contributor:
    fullname: G Manukian
– volume: 82
  start-page: 1
  year: 2017
  ident: 34676_CR29
  publication-title: Eur. J. Cancer
  doi: 10.1016/j.ejca.2017.05.035
  contributor:
    fullname: A Al-Mamgani
– volume: 19
  start-page: 24
  year: 2018
  ident: 34676_CR50
  publication-title: Am. J. Clin. Dermatol
  doi: 10.1007/s40257-018-0379-0
  contributor:
    fullname: A Gonzalez
– volume: 1874
  start-page: 188439
  year: 2020
  ident: 34676_CR34
  publication-title: Biochim Biophys. Acta Rev. Cancer
  doi: 10.1016/j.bbcan.2020.188439
  contributor:
    fullname: T Li
– volume: 12
  start-page: 643291
  year: 2021
  ident: 34676_CR11
  publication-title: Front Immunol.
  doi: 10.3389/fimmu.2021.643291
  contributor:
    fullname: KM van Pul
– volume: 5
  start-page: 14
  year: 2017
  ident: 34676_CR16
  publication-title: J. Immunother. Cancer
  doi: 10.1186/s40425-017-0216-7
  contributor:
    fullname: G Kueberuwa
– volume: 24
  start-page: 5058
  year: 2018
  ident: 34676_CR12
  publication-title: Clin. Cancer Res.
  doi: 10.1158/1078-0432.CCR-17-3427
  contributor:
    fullname: AE Marciscano
– volume: 520
  start-page: 692
  year: 2015
  ident: 34676_CR41
  publication-title: Nature
  doi: 10.1038/nature14426
  contributor:
    fullname: S Kreiter
– ident: 34676_CR10
  doi: 10.3390/cancers13184616
– ident: 34676_CR57
  doi: 10.3791/59195
– volume: 5
  start-page: 148
  year: 2017
  ident: 34676_CR8
  publication-title: Cancer Immunol. Res.
  doi: 10.1158/2326-6066.CIR-16-0107
  contributor:
    fullname: T Wang
– volume: 36
  start-page: 1747
  year: 2014
  ident: 34676_CR28
  publication-title: Head. Neck
  doi: 10.1002/hed.23535
  contributor:
    fullname: JL Campian
– volume: 24
  start-page: 2032
  year: 2018
  ident: 34676_CR22
  publication-title: Clin. Cancer Res.
  doi: 10.1158/1078-0432.CCR-17-3644
  contributor:
    fullname: M Gerlinger
– volume: 28
  start-page: 5
  year: 2021
  ident: 34676_CR32
  publication-title: Cancer Gene Ther.
  doi: 10.1038/s41417-020-0183-x
  contributor:
    fullname: RE Tay
– volume: 199
  start-page: 3348
  year: 2017
  ident: 34676_CR44
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.1700643
  contributor:
    fullname: A Memarnejadian
– volume: 54
  start-page: 2338
  year: 2021
  ident: 34676_CR9
  publication-title: Immunity
  doi: 10.1016/j.immuni.2021.08.026
  contributor:
    fullname: JM Schenkel
– ident: 34676_CR13
  doi: 10.3390/ijms22179401
– volume: 20
  start-page: 812
  year: 2015
  ident: 34676_CR3
  publication-title: Oncologist
  doi: 10.1634/theoncologist.2014-0422
  contributor:
    fullname: GK Pennock
– volume: 113
  start-page: 2182
  year: 2016
  ident: 34676_CR24
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.1516485113
  contributor:
    fullname: AP Benechet
– volume: 592
  start-page: 463
  year: 2021
  ident: 34676_CR36
  publication-title: Nature
  doi: 10.1038/s41586-021-03363-z
  contributor:
    fullname: M Platten
– volume: 180
  start-page: 3122
  year: 2008
  ident: 34676_CR37
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.180.5.3122
  contributor:
    fullname: SB Wong
– volume: 111
  start-page: 936
  year: 2021
  ident: 34676_CR27
  publication-title: Int J. Radiat. Oncol. Biol. Phys.
  doi: 10.1016/j.ijrobp.2021.07.1695
  contributor:
    fullname: PJJ Damen
– volume: 39
  start-page: 30
  year: 2021
  ident: 34676_CR5
  publication-title: J. Clin. Oncol.
  doi: 10.1200/JCO.20.00290
  contributor:
    fullname: S McBride
– ident: 34676_CR54
  doi: 10.1136/jitc-2021-002568
– volume: 24
  start-page: 5368
  year: 2018
  ident: 34676_CR59
  publication-title: Clin. Cancer Res
  doi: 10.1158/1078-0432.CCR-18-1038
  contributor:
    fullname: A Oweida
– volume: 26
  start-page: 4442
  year: 2020
  ident: 34676_CR23
  publication-title: Clin. Cancer Res.
  doi: 10.1158/1078-0432.CCR-20-0305
  contributor:
    fullname: P Brossart
– volume: 22
  start-page: 450
  year: 2021
  ident: 34676_CR4
  publication-title: Lancet Oncol.
  doi: 10.1016/S1470-2045(20)30737-3
  contributor:
    fullname: NY Lee
– volume: 31
  start-page: 100812
  year: 2022
  ident: 34676_CR31
  publication-title: Neoplasia
  doi: 10.1016/j.neo.2022.100812
  contributor:
    fullname: I Telarovic
– volume: 18
  start-page: 873
  year: 2020
  ident: 34676_CR6
  publication-title: J. Natl Compr. Canc Netw.
  doi: 10.6004/jnccn.2020.0031
  contributor:
    fullname: DG Pfister
– ident: 34676_CR18
  doi: 10.1172/jci.insight.124507
– volume: 13
  year: 2022
  ident: 34676_CR14
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-022-31941-w
  contributor:
    fullname: R Saddawi-Konefka
– ident: 34676_CR30
  doi: 10.1136/jitc-2020-000867
– volume: 173
  start-page: 4443
  year: 2004
  ident: 34676_CR20
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.173.7.4443
  contributor:
    fullname: S Kandula
– volume: 29
  start-page: 2232
  year: 2018
  ident: 34676_CR47
  publication-title: Ann. Oncol.
  doi: 10.1093/annonc/mdy399
  contributor:
    fullname: B Szekely
– ident: 34676_CR58
– volume: 22
  start-page: 371
  year: 2005
  ident: 34676_CR39
  publication-title: Immunity
  doi: 10.1016/j.immuni.2005.02.003
  contributor:
    fullname: A Corthay
– volume: 12
  year: 2021
  ident: 34676_CR53
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-021-21383-1
  contributor:
    fullname: R Duhen
– volume: 11
  start-page: 586907
  year: 2020
  ident: 34676_CR33
  publication-title: Front Immunol.
  doi: 10.3389/fimmu.2020.586907
  contributor:
    fullname: M Zuazo
– volume: 168
  start-page: 487
  year: 2017
  ident: 34676_CR21
  publication-title: Cell
  doi: 10.1016/j.cell.2016.12.022
  contributor:
    fullname: MH Spitzer
SSID ssj0000391844
Score 2.6290298
Snippet In the setting of conventional radiation therapy, even when combined with immunotherapy, head and neck cancer often recurs locally and regionally. Elective...
Abstract In the setting of conventional radiation therapy, even when combined with immunotherapy, head and neck cancer often recurs locally and regionally....
Neck dissection and/or elective nodal irradiation (ENI) are commonly performed in patients with head and neck squamous cell carcinoma (HNSCC) to minimize local...
SourceID doaj
pubmedcentral
proquest
crossref
pubmed
SourceType Open Website
Open Access Repository
Aggregation Database
Index Database
StartPage 7015
SubjectTerms Antigens
Cancer
Combined Modality Therapy
Epitopes
Head & neck cancer
Head and neck carcinoma
Head and Neck Neoplasms - radiotherapy
Humans
Immune response
Immune system
Immunity
Immunotherapy
Irradiation
Lymph Node Excision
Lymph nodes
Lymphocytes
Lymphocytes T
Metastases
Priming
Radiation
Radiation therapy
Regional development
Sentinel Lymph Node
Squamous cell carcinoma
Tumors
SummonAdditionalLinks – databaseName: DOAJ Directory of Open Access Journals
  dbid: DOA
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Na9wwEBUhUMilNGnSOh9FhdyCqW3JsnRsS0IotKcGchP6cmvaaMOul7A_Iv-5o5Gz3S2FXnozlmzLmtHoPSS9IeTcBNNL1VWlqlpXcuer0rrWl8b0oQWO23SYG_DzF3F9wz_dtrcbqb7SnrAsD5w7LiUbcwymUeu84FYqwy2vpPfKMEDewWP0rdsNMoUxmCmgLnw6JVMx-W7BMSbg5nW4EOXD1kyEgv1_Q5l_bpbcmH2uXpDnE2yk73Nz98lOiAfkWU4kuXpJHi9_5sBF48xDvWE-T5oDqdPp3YAyGmFBcd6iJnqa9ZsHRwc8HjKu6DeUnwb4Se2KghcCYc6P_35RehDrT4e2VnSIFGK5x5IY3A86Lu9m88Uhubm6_PrxupwSLZQOANRYGqBJjAPTcrWXvYRBHuqm76peeUAErrXeM24ay7mvjZRe9UzK0BnFGGfSWXZEduMshteEAv8JrjLS16LirrbSMZYyzdpQszaYpiAXT52u77OehsZ1cCZ1NpEGE2k0kX4oyIdkl3XNpIWNN8BD9OQh-l8eUpDTJ6vqaYAuNKA2oZgCwlSQt-tiGFppvcTEMFtinY4LodquIK-yE6xbAh8ErMrhf7ot99hq6nZJHL6jfDcQTKA14vh__NsJ2WuSS6d9ieKU7I7zZTgDlDTaNzggfgFaehLu
  priority: 102
  providerName: Directory of Open Access Journals
– databaseName: Health & Medical Collection
  dbid: 7X7
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1bi9QwFA7riuCLeLe6SgTfJEzbpLk8icoug6BPLsxbyK1r0U3XTodlfoT_2ZO0M-uI-Faa0zbNOTn5Ti7fQeiNCaaVSpRElY0jzPmSWNd4YkwbGohxa5FzA37-wpfn7NOqWR2h5e4sTNpWufOJ2VH73qU58gUMs1xRBQh3YWyaBXDj4t3VT5LyR6V11jmZxi10u6oBVoBli5XYz7YkHnTJ2HxqpqRysWbZR-TN7HDByfXByJQJ_P-FOv_ePPnHaHR2H92bYSR-P-n9AToK8SG6MyWW3D5Cv05_TI4Mx96DXDcMiYMgKQFfdplWI6xxHsewiR5PfM6dw10-LjJu8UWmowY4iu0WQwtBAD09fvOi9GCWnw9xbXEXMfh2n0ticN_xuLnsh_VjdH52-vXjksyJF4gDQDUSA2ETZRB5ucrLVkKnD1XdirJVHhCCa6z3lJnaMuYrI6VXLZUyCKMoZVQ6S5-g49jH8AxhiIeCK430FS-Zq6x0lKbMszZUtAmmLtDbXaPrq4lfQ-d1cSr1pCINKtJZRfq6QB-SXvaSiRs73-iHCz13tcR26igAL-s8Z1YqwywrpffKUIjVgi_QyU6reu6wa31jXgV6vS-GrpbWT0wM_SbLCMa5akSBnk5GsK8JfBCwK4P_EQfmcVDVw5LYfct03hBwQpjDn_-_Wi_Q3ToZa9qByE_Q8ThswkvAQ6N9lU39N42tDhY
  priority: 102
  providerName: ProQuest
– databaseName: Scholars Portal Open Access Journals
  dbid: M48
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV1Nb9QwELVKERIXVL4DBRmJGzIksePYhwoBalUhwYmVerP8lRLRJm02q5IfwX9mbGcXFu2BmxVPEicztt-T7TcIvdZeN0LWOZF5ZQmzLifGVo5o3fgKOG5Zx9yAX77y0wX7fFad7aF1uqP5By53UruQT2oxXLz9eT29hw5_lI6Mi3dLFrt73JcOBU5ubqHbJYNy2Mo3w_04MlMJhCYsNJc5KwjM3XQ-R7P7MVtzVZT034VD_91O-df8dHKA7s3AEn9IkXAf7fnuAbqTUk1OD9Gv44s0tOGud2DXDkNQJQhuwZdtFNrwSxxnNqw7h5PCc2txGw-QjBM-jwLVAFCxmTDEKVDqdPufB4Ubo_18rGvCbYdhtHexpvP2Bx5Xl_2wfIQWJ8ffPp2SORUDsQCxRqKBSFEGXMwWTjQChgFflE2dN9IBZrCVcY4yXRrGXKGFcLKhQvhaS0oZFdbQx2i_6zv_FGFgSN7mWriC58wWRlhKQy5a4wtaeV1m6M36p6urpLih4ko5FSq5SIGLVHSRusnQx-CXjWVQy44X-uFczZ0v6J9aClDMWMeZEVIzw3LhnNQU2Jt3GTpce1WtI1ABruOSSqBUGXq1qYbOF1ZUdOf7VbSpGeeyqjP0JAXBpiXwQkCzDL6n3gqPraZu13Tt9yjwDRQUiA9_9h_vfY7uliFiw8ZEfoj2x2HlXwBMGs3LGPu_AcPEEbY
  priority: 102
  providerName: Scholars Portal
Title Elective nodal irradiation mitigates local and systemic immunity generated by combination radiation and immunotherapy in head and neck tumors
URI https://www.ncbi.nlm.nih.gov/pubmed/36385142
https://www.proquest.com/docview/2736939306/abstract/
https://www.proquest.com/docview/2737466957/abstract/
https://pubmed.ncbi.nlm.nih.gov/PMC9668826
https://doaj.org/article/003c3639bcd64b89a4b408dd9a3666ed
Volume 13
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1da9swFBVtx2AvY9_z2gUN9jbc2JZsS49pSVYCKWVbIW9GX-7MGqU4DiU_Yv-519dO1ow97cUJkeTIvvdK59hXR4R8Vk6VQuZRKKPUhNzYKNQmtaFSpUuB4yY57g04u8wurvl0ns4PSLpdC4NJ-0ZXp_52ceqrn5hbebcww22e2PBqdg4QHYBhNjwkhzljjyg6Dr9MAmvh_QKZiInhiuNwgHnr8CUL7_cmIdTq_xfA_DtP8tHEM3lBnveIkY66nr0kB86_Ik-7PSQ3r8nv8W03ZlG_tFCvqutWbqC933RRoYKGW1GcsqjylnbSzZWhFa4MaTb0BpWnAXlSvaHggMCVu-Z_TtQ2xPr9eq0NrTyFYdxiiXfmF23Wi2W9ekOuJ-Mf5xdhv8dCaAA7NaEChsQ4kCwTW1EKiG8XJ2UeldICGDCptpZxlWjObayEsLJkQrhcScY4E0azt-TIL717TyhQH2ciJWycRdzEWhjG2k1mtYtZ6lQSkC_bm17cdVIaBb4CZ6LoTFSAiQo0UXEfkLPWLruarQw2_rCsb4reGVphU8MAY2ljM66FVFzzSFgrFQNa5mxATrZWLfrYXBUA2DLJJHClgHzaFUNUta9KlHfLNdbJeZbJNA_Iu84Jdj2BPwSYyuF68j332Ovqfgk4Mip394774b9bHpNnSevHbR5idkKOmnrtPgIqavQAYmGew1FMvg7Ik9Fo-n0Kn2fjy6tvA3zSAMcZFwOMlgfIohhz
link.rule.ids 230,315,733,786,790,870,891,2115,2236,12083,12792,21416,24346,27957,27958,31754,31755,33408,33409,33779,33780,43345,43635,43840,53827,53829,74102,74392,74659
linkProvider National Library of Medicine
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1Lb9QwELagCNELKs8GChiJG4qaxI5jnxCtWi3Q9tRKe7P8SomgSUmyqvZH8J8ZO95tFyFuUewkjmc8_sYef4PQB-VUzUWVpSIrTUqNzVJtSpsqVbsSfNyiCrkBT8_Y7IJ-nZfzuOA2xLDKlU0Mhtp2xq-R78M0ywQRgHA_Xf9KfdYov7saU2jcRw8oIdSH9FXzar3G4tnPOaXxrExG-P5Ag2UIIexwwdKbjfko0Pb_C2v-HTJ5Zw463kGPI3jEnydpP0H3XPsUPZzSSS6fod9HPyfzhdvOQr2m7z3zgO96fNUEMg034DB7YdVaPLE4NwY34ZDIuMSXgYQaQCjWSwz9Am7z9Pjti_yDoX48urXETYvBottQ0jrzA4-Lq64fnqOL46Pzw1ka0y2kBmDUmCpwlggFf8vkltcchrrLi7rKamEBF5hSW0uoKjSlNlecW1ETzl2lBPQ84UaTF2ir7Vq3izB4Qc5kitucZdTkmhtCfL5Z7XJSOlUk6OOq0-X1xKohw2444XISkQQRySAieZOgAy-XdU3PiB1udP2ljAPMc5waAnBLG8uo5kJRTTNurVAEPDRnE7S3kqqMw3SQt0qVoPfrYhhgftdEta5bhDoVZUyUVYJeTkqwbgl8EBArhf-pNtRjo6mbJW3zPZB4g5sJzg179f9mvUOPZuenJ_Lky9m312i78IrrYxDZHtoa-4V7A4ho1G-D2v8BrTgNSQ
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1Lb9QwELagFYgL4tkGWjASNxRtEjuJfUK03VV5rSpEpd4sv1Ii2qQkWVX7I_jPjB3vtosQtyh2EsczHn9jj79B6K20smK8TGKe5Dqm2iSx0rmJpaxsDj5uVvrcgF_nxfEp_XSWn4X4pz6EVa5sojfUptVujXwC02zBCQeEO6lCWMTJ0ez91a_YZZByO60hncZdtF3SIgcN3z6Yzk--rVdcHBc6ozScnEkIm_TU2wkf0A4XRXy9MTt5Ev9_Ic-_AyhvzUizR-hhgJL4wyj7x-iObZ6ge2NyyeVT9Ht6MRoz3LQG6tVd53gInCDwZe2pNWyP_VyGZWPwyOlca1z7IyPDEp97SmqApFgtMfQSONHj4zcvcg_6-uEg1xLXDQb7bnxJY_VPPCwu265_hk5n0--Hx3FIvhBrAFVDLMF1IhS8L50aVjEY-DbNqjKpuAGUoHNlDKEyU5SaVDJmeEUYs6XkhFDCtCLP0VbTNnYXYfCJrE4kM2mRUJ0qpglx2WeVTUluZRahd6tOF1cjx4bwe-OEiVFEAkQkvIjEdYQOnFzWNR0_tr_RduciDDfHeKoJgC-lTUEV45IqmjBjuCTgr1kTob2VVEUYtL24UbEIvVkXw3Bzeyiyse3C1wHtKnheRmhnVIJ1S-CDgF8p_E-5oR4bTd0saeofntIbnE5wdYoX_2_Wa3QfdF58-Tj__BI9yJzeuoDEYg9tDd3C7gM8GtSroPd_AMksEuw
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Elective+nodal+irradiation+mitigates+local+and+systemic+immunity+generated+by+combination+radiation+and+immunotherapy+in+head+and+neck+tumors&rft.jtitle=Nature+communications&rft.au=Darragh%2C+Laurel+B&rft.au=Gadwa%2C+Jacob&rft.au=Pham%2C+Tiffany+T&rft.au=Van+Court%2C+Benjamin&rft.date=2022-11-16&rft.issn=2041-1723&rft.eissn=2041-1723&rft.volume=13&rft.issue=1&rft.spage=7015&rft_id=info:doi/10.1038%2Fs41467-022-34676-w&rft.externalDBID=NO_FULL_TEXT
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2041-1723&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2041-1723&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2041-1723&client=summon