Progesterone and vitamin D: Improvement after traumatic brain injury in middle-aged rats

• Published in: Hormones and behavior Vol. 64; no. 3; pp. 527 - 538
• Main Authors: Tang, Huiling, Hua, Fang, Wang, Jun, Sayeed, Iqbal, Wang, Xiaojing, Chen, Zhengjia, Yousuf, Seema, Atif, Fahim, Stein, Donald G.
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier Inc 01.08.2013; Elsevier; Elsevier BV
• Subjects: Adult and adolescent clinical studies; Aging; Aging - drug effects; Aging - physiology; Animal cognition; Animal memory; Animals; Behavioral psychophysiology; Biological and medical sciences; Brain damage; Brain Injuries - complications; Brain Injuries - drug therapy; Combination treatments; Cytoprotection - drug effects; Disease Models, Animal; Drug Evaluation, Preclinical; Drug therapy; Functional repair; Fundamental and applied biological sciences. Psychology; Hormones and behavior; Injuries of the nervous system and the skull. Diseases due to physical agents; Male; Maze Learning - drug effects; Medical sciences; Neuroprotective Agents - administration & dosage; Organic mental disorders. Neuropsychology; Progesterone; Progesterone - administration & dosage; Psychology. Psychoanalysis. Psychiatry; Psychology. Psychophysiology; Psychopathology. Psychiatry; Rats; Rats, Sprague-Dawley; Rodents; Swimming; Traumas. Diseases due to physical agents; Traumatic brain injury; Vitamin D; Vitamin D - administration & dosage; Vitamin D deficiency; Vitamin D Deficiency - complications; Vitamin D Deficiency - drug therapy; Vitamin D3 hormone; Vitamin D deficiency; Traumatic brain injury; Functional repair; Vitamin D3 hormone; Aging; Progesterone; Combination treatments; Senescence; Rat; Progestagen; Vitamin D; Adult; Repair; Nutritional status; Human; Nervous system diseases; Rodentia; Nutrition disorder; Ovarian hormone; Micronutrient; Vertebrata; Mammalia; Animal; Combined treatment; Head trauma; Sex steroid hormone

Progesterone (PROG) and vitamin D hormone (VDH) have both shown promise in treating traumatic brain injury (TBI). Both modulate apoptosis, inflammation, oxidative stress, and excitotoxicity. We investigated whether 21days of VDH deficiency would alter cognitive behavior after TBI and whether combine...