Rap1 protein regulates telomere turnover in yeast

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 95; no. 21; pp. 12486 - 12491
• Main Authors: Krauskopf, A. (University of California, San Francisco, CA.), Blackburn, E.H
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences of the United States of America 13.10.1998; National Acad Sciences; National Academy of Sciences; The National Academy of Sciences
• Subjects: ADN; Alleles; BINDING PROTEINS; Biological Sciences; Cell division; CHROMOSOME; CHROMOSOMES; CROMOSOMAS; DNA; DNA, Fungal; DNA-Binding Proteins - physiology; DOUBLE STRANDED DNA BINDING PROTEINS; Gene expression regulation; Genetic mutation; Genetics; Genomics; Kluyveromyces - genetics; Kluyveromyces lactis; KLUYVEROMYCES MARXIANUS; KLUYVEROMYCES MARXIANUS VAR. LACTIS; LARGURA; LENGTH; LONGUEUR; MUTACION; MUTANT; MUTANTES; MUTANTS; MUTATION; Phenotype; PROTEINAS AGLUTINANTES; PROTEINE DE LIAISON; Proteins; REGULATION; REPETITIVE DNA; RNA; Saccharomyces cerevisiae Proteins; Telomere; Telomere-Binding Proteins; Telomeres; TELOMERIC REPEATS; Transcription Factors; Truncation; Yeast; Yeasts

Telomere length is maintained through a dynamic balance between addition and loss of the terminal telomeric DNA. Normal telomere length regulation requires telomerase as well as a telomeric protein-DNA complex. Previous work has provided evidence that in the budding yeasts Kluyveromyces lactis and S...