NetMHCpan, a method for MHC class I binding prediction beyond humans

• Published in: Immunogenetics (New York) Vol. 61; no. 1; pp. 1 - 13
• Main Authors: Hoof, Ilka, Peters, Bjoern, Sidney, John, Pedersen, Lasse Eggers, Sette, Alessandro, Lund, Ole, Buus, Søren, Nielsen, Morten
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Berlin/Heidelberg : Springer-Verlag 01.01.2009; Springer-Verlag; Springer Nature B.V
• Subjects: Algorithms; Allergology; Amino Acid Sequence; Animals; Binding specificity; Biomedical and Life Sciences; Biomedicine; Cell Biology; chemistry; Computer Simulation; CTL epitopes; Epitopes, T-Lymphocyte; Epitopes, T-Lymphocyte - chemistry; Epitopes, T-Lymphocyte - immunology; Epitopes, T-Lymphocyte - metabolism; Gene Function; Genes, MHC Class I; genetics; Gorilla gorilla; Gorilla gorilla - genetics; Gorilla gorilla - immunology; Histocompatibility Antigens Class I; Histocompatibility Antigens Class I - immunology; Histocompatibility Antigens Class I - metabolism; HLA Antigens; HLA Antigens - genetics; HLA Antigens - immunology; HLA Antigens - metabolism; Human Genetics; Humans; Immune system; Immunity, Cellular; Immunology; Macaca mulatta; Macaca mulatta - genetics; Macaca mulatta - immunology; Medical research; metabolism; MHC class I; Mice; Models, Biological; neural networks; Neural Networks, Computer; Non-human primates; Oligopeptides; Oligopeptides - immunology; Oligopeptides - metabolism; Original Paper; Pan troglodytes; Pan troglodytes - genetics; Pan troglodytes - immunology; Peptides; Protein Binding; Protein Interaction Domains and Motifs; Protein Interaction Mapping; Species Specificity; Sus scrofa; Sus scrofa - genetics; Sus scrofa - immunology; MHC class I; CTL epitopes; Non-human primates; Binding specificity; Artificial neural networks

Binding of peptides to major histocompatibility complex (MHC) molecules is the single most selective step in the recognition of pathogens by the cellular immune system. The human MHC genomic region (called HLA) is extremely polymorphic comprising several thousand alleles, each encoding a distinct MH...