An Atomic Model of the Tropomyosin Cable on F-actin

• Published in: Biophysical journal Vol. 107; no. 3; pp. 694 - 699
• Main Authors: Orzechowski, Marek, Li, Xiaochuan (Edward), Fischer, Stefan, Lehman, William
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 05.08.2014; Biophysical Society; The Biophysical Society
• Subjects: Actins - chemistry; Actins - metabolism; Amino Acid Sequence; Atoms & subatomic particles; Biochemistry; Biophysics; Molecular biology; Molecular Dynamics Simulation; Molecular Machines, Motors and Nanoscale Biophysics; Molecular Sequence Data; Mutation; Protein Binding; Protein Structure, Tertiary; Proteins; Tropomyosin - chemistry; Tropomyosin - metabolism

Tropomyosin regulates a wide variety of actin filament functions and is best known for the role that it plays together with troponin in controlling muscle activity. For effective performance on actin filaments, adjacent 42-nm-long tropomyosin molecules are joined together by a 9- to 10-residue head-...