Role of Interleukin-4, Interleukin-10, and Tumor Necrosis Factor-α Polymorphic Genes in the Pathogenesis of Occupational Allergic Dermatoses

• Published in: Bulletin of experimental biology and medicine Vol. 159; no. 6; pp. 779 - 781
• Main Authors: Kuz’mina, L. P., Izmerova, N. I., Kolyaskina, M. M.
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.10.2015; Springer
• Subjects: Amino Acid Substitution; Asthma - epidemiology; Asthma - genetics; B cells; Biomedical and Life Sciences; Biomedicine; Case-Control Studies; Cell Biology; Dermatitis, Atopic - epidemiology; Dermatitis, Atopic - genetics; Development and progression; Eczema - epidemiology; Eczema - genetics; Genes; Genetic Association Studies; Genetic Predisposition to Disease; Humans; Interleukin-10 - genetics; Interleukin-4 - genetics; Interleukins; Internal Medicine; Laboratory Medicine; Occupational Diseases - epidemiology; Occupational Diseases - genetics; Pathology; Polymorphism, Single Nucleotide; Rankings; Skin diseases; Tumor necrosis factor; Tumor Necrosis Factor-alpha - genetics; Tumors; occupational allergic dermatoses; individual liability; cytokines
• ISSN: 0007-4888; 1573-8221
• DOI: 10.1007/s10517-015-3074-7

Study of polymorphic genes of pro- and anti-inflammatory cytokines (IL-4, IL-10, TNF-α) in patients with occupational allergic dermatoses showed significantly higher frequency of polymorphic variants of cytokine genes IL4 C589T , IL10 C819T , IL10 G1082A , IL10 C592A , and TNF G308A in comparison with the population control. The presence of homozygous variant IL10 G1082A – AA in 80% cases characterizes early disease development, i.e . within 3 years after the first exposure to the occupational factor.