Buccal epithelial cells display somatic, bone marrow–derived CALR mutation
•Buccal epithelial cells harbor an MPN-associated CALR mutation in a patient with CALR-mutant essential thrombocytosis, Ph+ CML, and no germ line CALR mutation.
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Published in | Blood advances Vol. 1; no. 25; pp. 2302 - 2306 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
United States
Elsevier Inc
28.11.2017
American Society of Hematology Elsevier |
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Abstract | •Buccal epithelial cells harbor an MPN-associated CALR mutation in a patient with CALR-mutant essential thrombocytosis, Ph+ CML, and no germ line CALR mutation. |
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AbstractList | •Buccal epithelial cells harbor an MPN-associated CALR mutation in a patient with CALR-mutant essential thrombocytosis, Ph+ CML, and no germ line CALR mutation. Buccal epithelial cells harbor an MPN-associated CALR mutation in a patient with CALR-mutant essential thrombocytosis, Ph+ CML, and no germ line CALR mutation. Key Points Buccal epithelial cells harbor an MPN-associated CALR mutation in a patient with CALR-mutant essential thrombocytosis, Ph+ CML, and no germ line CALR mutation. Buccal epithelial cells harbor an MPN-associated CALR mutation in a patient with CALR -mutant essential thrombocytosis, Ph + CML, and no germ line CALR mutation. Buccal epithelial cells harbor an MPN-associated mutation in a patient with -mutant essential thrombocytosis, Ph CML, and no germ line mutation. |
Author | Sachs, Zohar Baughn, Linda B. Courville, Elizabeth L. Nelson, Andrew C. Gilles, Scott R. Schomaker, Matthew L. |
Author_xml | – sequence: 1 givenname: Scott R. surname: Gilles fullname: Gilles, Scott R. organization: Department of Laboratory Medicine and Pathology, University of Minnesota Medical Center Fairview, Minneapolis, MN – sequence: 2 givenname: Linda B. surname: Baughn fullname: Baughn, Linda B. organization: Department of Laboratory Medicine and Pathology, University of Minnesota Medical Center Fairview, Minneapolis, MN – sequence: 3 givenname: Matthew L. surname: Schomaker fullname: Schomaker, Matthew L. organization: Department of Laboratory Medicine and Pathology, University of Minnesota Medical Center Fairview, Minneapolis, MN – sequence: 4 givenname: Elizabeth L. surname: Courville fullname: Courville, Elizabeth L. organization: Department of Laboratory Medicine and Pathology, University of Minnesota Medical Center Fairview, Minneapolis, MN – sequence: 5 givenname: Andrew C. surname: Nelson fullname: Nelson, Andrew C. email: nels2055@umn.edu organization: Department of Laboratory Medicine and Pathology, University of Minnesota Medical Center Fairview, Minneapolis, MN – sequence: 6 givenname: Zohar orcidid: 0000-0001-9386-4163 surname: Sachs fullname: Sachs, Zohar email: sachs038@umn.edu organization: Masonic Cancer Center and |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/29296879$$D View this record in MEDLINE/PubMed |
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Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 A.C.N. and Z.S. contributed equally to this work. S.R.G. and L.B.B. contributed equally to this work. |
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10.1016/S0140-6736(03)12894-2 contributor: fullname: Tran – volume: 25 start-page: 5630 issue: 35 year: 2007 ident: 2019111607112726200_B9 article-title: Familial chronic myeloproliferative disorders: clinical phenotype and evidence of disease anticipation publication-title: J Clin Oncol doi: 10.1200/JCO.2007.12.6896 contributor: fullname: Rumi – volume: 35 start-page: 1018 issue: 9 year: 2017 ident: 2019111607112726200_B21 article-title: Germline genetic predisposition to hematologic malignancy publication-title: J Clin Oncol doi: 10.1200/JCO.2016.70.8644 contributor: fullname: Furutani – volume: 28 start-page: 1357 issue: 6 year: 2014 ident: 2019111607112726200_B8 article-title: Looking for CALR mutations in familial myeloproliferative neoplasms publication-title: Leukemia doi: 10.1038/leu.2014.33 contributor: fullname: Maffioli – volume: 128 start-page: 144 issue: 1 year: 2016 ident: 2019111607112726200_B14 article-title: LNK mutations in familial myeloproliferative neoplasms publication-title: Blood doi: 10.1182/blood-2016-04-711150 contributor: fullname: Rumi – volume: 369 start-page: 2391 issue: 25 year: 2013 ident: 2019111607112726200_B2 article-title: Somatic CALR mutations in myeloproliferative neoplasms with nonmutated JAK2 publication-title: N Engl J Med doi: 10.1056/NEJMoa1312542 contributor: fullname: Nangalia – ident: 2019111607112726200_B19 article-title: Novel germline mutations in the calreticulin gene: implications for the diagnosis of myeloproliferative neoplasms [published online ahead of print 27 July 2016]. J Clin Pathol. doi:10.1136/jclinpath-2016-203940. contributor: fullname: Szuber |
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Snippet | •Buccal epithelial cells harbor an MPN-associated CALR mutation in a patient with CALR-mutant essential thrombocytosis, Ph+ CML, and no germ line CALR mutation. Buccal epithelial cells harbor an MPN-associated mutation in a patient with -mutant essential thrombocytosis, Ph CML, and no germ line mutation. Key Points Buccal epithelial cells harbor an MPN-associated CALR mutation in a patient with CALR-mutant essential thrombocytosis, Ph+ CML, and no germ line... Buccal epithelial cells harbor an MPN-associated CALR mutation in a patient with CALR-mutant essential thrombocytosis, Ph+ CML, and no germ line CALR mutation. Buccal epithelial cells harbor an MPN-associated CALR mutation in a patient with CALR -mutant essential thrombocytosis, Ph + CML, and no germ line CALR... |
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Title | Buccal epithelial cells display somatic, bone marrow–derived CALR mutation |
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