Genetic variants in human CLOCK associate with total energy intake and cytokine sleep factors in overweight subjects (GOLDN population)

• Published in: European journal of human genetics : EJHG Vol. 18; no. 3; pp. 364 - 369
• Main Authors: Garaulet, Marta, Lee, Yu-Chi, Shen, Jian, Parnell, Laurence D, Arnett, Donna K, Tsai, Michael Y, Lai, Chao-Qiang, Ordovas, Jose M
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01.03.2010; Nature Publishing Group
• Subjects: Adiponectin; Alleles; Bioinformatics; Biological and medical sciences; Biomedical and Life Sciences; Biomedicine; Body weight; Carbohydrates; Circadian rhythm; Circadian rhythms; CLOCK protein; CLOCK Proteins - genetics; Cytogenetics; Cytokines; Cytokines - genetics; Dietary intake; Drugs; Energy; Energy intake; Energy Intake - genetics; Fat protein; Female; Food; Food intake; Fundamental and applied biological sciences. Psychology; Gene Expression; Gene polymorphism; General aspects. Genetic counseling; Genes; Genetic diversity; Genetic variance; Genetic Variation; Genetics; Genetics of eukaryotes. Biological and molecular evolution; Genotype; Human Genetics; Humans; Insulin; Interleukin 2; Interleukin 6; Interleukins - genetics; Inventories; Kinases; Linkage Disequilibrium - genetics; Lipids; Male; Medical genetics; Medical sciences; Metabolic diseases; Metabolic syndrome; Molecular and cellular biology; Monocyte chemoattractant protein 1; Monocytes; Necrosis; Nutrition research; Obesity; Overweight - genetics; Overweight - physiopathology; Physiology; Polymorphism, Single Nucleotide - genetics; Proteins; Rodents; Single-nucleotide polymorphism; Sleep; Sleep - genetics; Sleep - physiology; Studies; Tumor necrosis factor; Tumor necrosis factor-a; Tumor necrosis factor-TNF; Tumor necrosis factor-α; United States > US; Spain; energy intake; metabolic syndrome; circadian; CLOCK; obesity; interleukin-6; Endocrinopathy; Human; Obesity; Genetic variant; Nutrition disorder; Cytokine; Metabolic diseases; Cardiovascular disease; Metabolic syndrome; Overweight; Interleukin 6; Sleep; Genetics; Population; Nutritional status

Despite the importance of total energy intake in circadian system regulation, no study has related human CLOCK gene polymorphisms and food-intake measures. The aim of this study was to analyze the associations of CLOCK single-nucleotide polymorphisms (SNPs) with food intake and to explore the specif...