Radiosynthesis and in vivo evaluation of [ 11C]MP-10 as a positron emission tomography radioligand for phosphodiesterase 10A - Plisson, Christophe; Salinas, Cristian; Weinzimmer, David; Labaree, David; Lin, Shu-Fei; Ding, Yu-Shin; Jakobsen, Steen; Smith, Paul W.; Eiji, Kawanishi; Carson, Richard E.; Gunn, Roger N.; Rabiner, Eugenii A. (Nuclear medicine and biology, 2011)
Keywords: Animals; Biological and medical sciences; Brain; Carbon Radioisotopes; Carbon-11; Contrast media. Radiopharmaceuticals; Enzyme Inhibitors - chemical synthesis; Enzyme Inhibitors - metabolism; Female; Humans; In vivo; Kinetics; Ligands; Medical sciences; MP-10; Papio; PDE10A; PET; Pharmacology. Drug treatments; Phosphoric Diester Hydrolases - metabolism; Positron-Emission Tomography - methods; Pyrazoles - chemical synthesis; Pyrazoles - metabolism; Quinolines - chemical synthesis; Quinolines - metabolism; Radiochemistry - methods; Radiology; Substrate Specificity; Swine; In vivo; Brain; PDE10A; MP-10; Carbon-11; PET; Radionuclide study; Nuclear medicine; Central nervous system; Monkey; Esterases; Phosphoric diester hydrolases; Encephalon; Primates; Radioisotopic product; Chemical synthesis; Ungulata; Biomedical engineering; 3',5'-Cyclic-nucleotide phosphodiesterase; Radiolabelling; Enzyme; Enzyme inhibitor; Pig; Vertebrata; Mammalia; Animal; Hydrolases; Artiodactyla; Positron emission tomography; Emission tomography