Stem cell therapy for osteonecrosis of femoral head: Opportunities and challenges

• Published in: Regenerative therapy Vol. 15; pp. 295 - 304
• Main Authors: Xu, Yingxing, Jiang, Yaping, Xia, ChangSuo, Wang, Yingzhen, Zhao, Zhiping, Li, Tao
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.12.2020; Japanese Society for Regenerative Medicine; Elsevier
• Subjects: Cell implantation; Cell therapy; Femoral head; Osteonecrosis; Review; Stem cells; Tissue engineering; RCT; SVF; Cell therapy; Femoral head; ONFH; ALP; MRI; VAS; Osteonecrosis; BMP-2; THA; TNF; DBM; β-TCP; AMSCs; HHS; MSCs; IP-CHA; BMC; XACB; CD; CSS; PBMSCs; UCMSCs; Tissue engineering; VEGF; Cell implantation; BCP; bFGF; TMCs; PLGA; SCPP; Stem cells; CPC; WOMAC; MVD; BMMNCs; BMSCs; VAS, visual analogue scale; AMSCs, adipose-derived MSCs; β-TCP, beta-tricalcium phosphate; CD, Core decompression; UCMSCs, umbilical cord-derived mesenchymal stem cells; ALP, alkaline phosphatase; CPC, calcium phosphate; HHS, Harris hip score; ONFH, Osteonecrosis of the femoral head; RCT, randomized controlled trial; CSS, cap-shaped separation; WOMAC, Western Ontario and McMaster Universities Arthritis Index; IP-CHA, interconnected porous calcium hydroxyapatite; SVF, stromal vascular fractions; MVD, microvessel density; TNF, tumor necrosis factor; BMC, bone marrow concentrate; VEGF, vascular endothelial growth factor; BMMNCs, bone marrow mononuclear cells; BCP, biphasic calcium phosphate; SCPP, strontium-doped calcium polyphosphate; THA, total hip arthroplasty; MRI, magnetic resonance imaging; TMCs, transformed mesenchymal cells; DBM, demineralized bone matrix; bFGF, basic fibroblast growth factor; BMSCs, bone marrow-derived mesenchymal stem cells; BMP-2, bone morphogenetic protein-2; MSCs, Mesenchymal stem cells; PLGA, poly lactide-co-glycolide; PBMSCs, peripheral blood-derived MSCs; XACB, xenogeneic antigen-extracted cancellous bone

Osteonecrosis of the femoral head (ONFH) is a progressive disease with a complex etiology and unclear pathogenesis, resulting in severe hip pain and dysfunction mainly observed in young patients. Although total hip arthroplasty (THA) is the most effective treatment for patients with ONFH in the term...