Stem cell therapy for osteonecrosis of femoral head: Opportunities and challenges - Xu, Yingxing; Jiang, Yaping; Xia, ChangSuo; Wang, Yingzhen; Zhao, Zhiping; Li, Tao (Regenerative therapy, 2020)
Keywords: Cell implantation; Cell therapy; Femoral head; Osteonecrosis; Review; Stem cells; Tissue engineering; RCT; SVF; Cell therapy; Femoral head; ONFH; ALP; MRI; VAS; Osteonecrosis; BMP-2; THA; TNF; DBM; β-TCP; AMSCs; HHS; MSCs; IP-CHA; BMC; XACB; CD; CSS; PBMSCs; UCMSCs; Tissue engineering; VEGF; Cell implantation; BCP; bFGF; TMCs; PLGA; SCPP; Stem cells; CPC; WOMAC; MVD; BMMNCs; BMSCs; VAS, visual analogue scale; AMSCs, adipose-derived MSCs; β-TCP, beta-tricalcium phosphate; CD, Core decompression; UCMSCs, umbilical cord-derived mesenchymal stem cells; ALP, alkaline phosphatase; CPC, calcium phosphate; HHS, Harris hip score; ONFH, Osteonecrosis of the femoral head; RCT, randomized controlled trial; CSS, cap-shaped separation; WOMAC, Western Ontario and McMaster Universities Arthritis Index; IP-CHA, interconnected porous calcium hydroxyapatite; SVF, stromal vascular fractions; MVD, microvessel density; TNF, tumor necrosis factor; BMC, bone marrow concentrate; VEGF, vascular endothelial growth factor; BMMNCs, bone marrow mononuclear cells; BCP, biphasic calcium phosphate; SCPP, strontium-doped calcium polyphosphate; THA, total hip arthroplasty; MRI, magnetic resonance imaging; TMCs, transformed mesenchymal cells; DBM, demineralized bone matrix; bFGF, basic fibroblast growth factor; BMSCs, bone marrow-derived mesenchymal stem cells; BMP-2, bone morphogenetic protein-2; MSCs, Mesenchymal stem cells; PLGA, poly lactide-co-glycolide; PBMSCs, peripheral blood-derived MSCs; XACB, xenogeneic antigen-extracted cancellous bone