Loss of the adaptor protein ShcA in endothelial cells protects against monocyte macrophage adhesion, LDL-oxydation, and atherosclerotic lesion formation

• Published in: Scientific reports Vol. 8; no. 1; pp. 4501 - 12
• Main Authors: Abou-Jaoude, Antoine, Badiqué, Lise, Mlih, Mohamed, Awan, Sara, Guo, Sunning, Lemle, Alexandre, Abboud, Clauda, Foppolo, Sophie, Host, Lionel, Terrand, Jérôme, Justiniano, Hélène, Herz, Joachim, Matz, Rachel L., Boucher, Philippe
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 14.03.2018; Nature Publishing Group
• Subjects: 13/51; 42/41; 45/77; 631/443/319/1557; 631/443/592/75/593/2100; 64/110; 82/80; 96/1; 96/106; 96/109; 96/63; 96/95; AKT protein; Arteriosclerosis; Atherosclerosis; Cell adhesion; Cellular Biology; Endothelial cells; Gene regulation; Homeobox; Humanities and Social Sciences; Intercellular adhesion molecule 1; Life Sciences; Low density lipoprotein; Macrophages; Monocytes; multidisciplinary; NF-κB protein; Nitric oxide; Nitric-oxide synthase; Receptor density; Science; Science (multidisciplinary); Transcription; Tyrosine; Yes-associated protein; Zinc finger proteins

ShcA is an adaptor protein that binds to the cytoplasmic tail of receptor tyrosine kinases and of the Low Density Lipoprotein-related receptor 1 (LRP1), a trans-membrane receptor that protects against atherosclerosis. Here, we examined the role of endothelial ShcA in atherosclerotic lesion formation...