Sirt1 and Sirt3 Activation Improved Cardiac Function of Diabetic Rats via Modulation of Mitochondrial Function

• Published in: Antioxidants Vol. 10; no. 3; p. 338
• Main Authors: Paramesha, Bugga, Anwar, Mohammed Soheb, Meghwani, Himanshu, Maulik, Subir Kumar, Arava, Sudheer Kumar, Banerjee, Sanjay K
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 24.02.2021; MDPI
• Subjects: biogenesis; cardiac output; Cell activation; Diabetes; Diabetes mellitus; Diet; Fatty acids; Fructose; Glucose; Heart; Hyperglycemia; Insulin; Insulin resistance; Laboratories; Metabolism; Mitochondria; mitochondrial dysfunction; Oxidative stress; OXPHOS; Proteins; rats; SIRT1 protein; Software; Structure-function relationships; synergism; Therapeutic targets; therapeutics; St Louis Missouri; Canada; United States > US; OXPHOS; mitochondrial dysfunction; insulin resistance; oxidative stress

In the present study, we aimed to evaluate the effect of Sirt1, Sirt3 and combined activation in high fructose diet-induced insulin resistance rat heart and assessed the cardiac function focusing on mitochondrial health and function. We administered the Sirt1 activator; SRT1720 (5 mg/kg, i.p.), Sirt...