Transplantation of autologous bone marrow-derived mesenchymal stem cells under arthroscopic surgery with microfracture versus microfracture alone for articular cartilage lesions in the knee: A multicenter prospective randomized control clinical trial

• Published in: Regenerative therapy Vol. 11; pp. 106 - 113
• Main Authors: Hashimoto, Yusuke, Nishida, Yohei, Takahashi, Shinji, Nakamura, Hiroaki, Mera, Hisashi, Kashiwa, Kaori, Yoshiya, Shinichi, Inagaki, Yusuke, Uematsu, Kota, Tanaka, Yasuhito, Asada, Shigeki, Akagi, Masao, Fukuda, Kanji, Hosokawa, Yoshiya, Myoui, Akira, Kamei, Naosuke, Ishikawa, Masakazu, Adachi, Nobuo, Ochi, Mitsuo, Wakitani, Shigeyuki
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.12.2019; Japanese Society for Regenerative Medicine; Elsevier
• Subjects: Bone marrow-derived mesenchymal stem cells; Microfracture; Original; Prospective randomized control clinical trial; KL; RCT; Microfracture; IKDC; Prospective randomized control clinical trial; KOOS; MRIs; QOL; GFP; CPC; HA; Bone marrow-derived mesenchymal stem cells; BMSCs; MFX; MOCART; GFP, green fluorescent protein; MOCART, magnetic resonance observation of cartilage repair tissue; CPC, cell processing centers; KL, Kellgren–Lawrence; KOOS, Knee Injury and Osteoarthritis Outcome Score; MRIs, magnetic resonance images; HA, hyaluronic acid; BMSCs, bone marrow-derived mesenchymal stem cells; RCT, randomized controlled trial; QOL, quality of life; MFX, microfracture; IKDC, International Knee Documentation committee

To investigate the efficacy of the transplantation of autologous bone marrow-derived mesenchymal stem cells (BMSCs) under arthroscopy with microfracture (MFX) compared with microfracture alone. Eleven patients with a symptomatic articular cartilage defect of the knee were included in the study. They...