Dose–response to 3 months of quercetin-containing supplements on metabolite and quercetin conjugate profile in adults

• Published in: British journal of nutrition Vol. 109; no. 11; pp. 1923 - 1933
• Main Authors: Cialdella-Kam, Lynn, Nieman, David C., Sha, Wei, Meaney, Mary Pat, Knab, Amy M., Shanely, R. Andrew
• Format: Journal Article
• Language: English
• Published: Cambridge, UK Cambridge University Press 14.06.2013
• Subjects: Adult; adults; Aged; Aged, 80 and over; antioxidants; Antioxidants - administration & dosage; Antioxidants - pharmacokinetics; Antioxidants - pharmacology; ascorbic acid; Ascorbic Acid - administration & dosage; Ascorbic Acid - pharmacokinetics; bile acids; Biological and medical sciences; blood sampling; blood serum; body mass index; Dietary Supplements; discriminant analysis; dose response; Dose-Response Relationship, Drug; Drug Interactions; Feeding. Feeding behavior; Female; fruits; Fundamental and applied biological sciences. Psychology; guaiacol; Humans; least squares; Liquid chromatography; Male; men; Metabolism; Metabolism and Metabolic Studies; Metabolites; Middle Aged; niacin; Niacin - administration & dosage; Niacin - pharmacokinetics; Oxidative stress; placebos; Polyphenols; quercetin; Quercetin - administration & dosage; Quercetin - pharmacology; statistical models; ultra-performance liquid chromatography; vegetables; Vertebrates: anatomy and physiology, studies on body, several organs or systems; vitamin D; women; Metabolic profiling; Flavonols; Quercetin conjugates; Dietary supplements; Nutrition; Metabolite; Supplemented diet; Antioxidant; Metabolism; Flavonoid; Profile; Feeding; Micronutrient; Polyphenol; Quercetin; Proanthocyanidin

Quercetin, a flavonol in fruits and vegetables, has been demonstrated to have antioxidant, anti-inflammatory and immunomodulating influences. The purpose of the present study was to determine if quercetin, vitamin C and niacin supplements (Q-500 = 500 mg/d of quercetin, 125 mg/d of vitamin C and 5 m...