In vitro to in vivo extrapolation for high throughput prioritization and decision making

• Published in: Toxicology in vitro Vol. 47; pp. 213 - 227
• Main Authors: Bell, Shannon M., Chang, Xiaoqing, Wambaugh, John F., Allen, David G., Bartels, Mike, Brouwer, Kim L.R., Casey, Warren M., Choksi, Neepa, Ferguson, Stephen S., Fraczkiewicz, Grazyna, Jarabek, Annie M., Ke, Alice, Lumen, Annie, Lynn, Scott G., Paini, Alicia, Price, Paul S., Ring, Caroline, Simon, Ted W., Sipes, Nisha S., Sprankle, Catherine S., Strickland, Judy, Troutman, John, Wetmore, Barbara A., Kleinstreuer, Nicole C.
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.03.2018; Elsevier Science Ltd
• Subjects: Animal Use Alternatives - trends; Animals; Assessments; Biocompatibility; Case studies; Chemical Safety - instrumentation; Chemical Safety - legislation & jurisprudence; Chemical Safety - methods; Chemical Safety - trends; Computational Biology; Computational toxicology; Computer Simulation; Decision making; Decision Making, Computer-Assisted; Decision Making, Organizational; Environmental protection; Expert Systems; Extrapolation; Guidelines as Topic; Health Priorities - trends; Health risks; High throughput testing; High-Throughput Screening Assays - trends; Humans; In vitro methods and tests; In vivo methods and tests; IVIVE; Models, Biological; National Institute of Environmental Health Sciences (U.S.); Organic chemistry; R&D; Research & development; Risk assessment; Safety; System effectiveness; Toxicity; Toxicity testing; Toxicity Tests - instrumentation; Toxicity Tests - methods; Toxicity Tests - trends; Toxicokinetic; Toxicology; United States; United States Dept. of Health and Human Services; United States Environmental Protection Agency; AOP; ADME; HTS; IVIVE; PBPK; High throughput testing; fu; QSAR; Computational toxicology; Risk assessment; TK; Toxicity testing; Toxicokinetic

In vitro chemical safety testing methods offer the potential for efficient and economical tools to provide relevant assessments of human health risk. To realize this potential, methods are needed to relate in vitro effects to in vivo responses, i.e., in vitro to in vivo extrapolation (IVIVE). Curren...